[특허]Analyzing bacteria without culturing

Analyzing bacteria without culturing 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/70 G01N-033/543 C12Q-001/68 G01N-033/569 B01L-003/00 C07K-001/22
출원번호	US-0496790 (2017-04-25)
등록번호	US-9869671 (2018-01-16)
발명자 / 주소	Dryga, Sergey A. Clarizia, Lisa-Jo Ann Adams, Eddie W. Esch, Victor C.
출원인 / 주소	DNAE Group Holdings Limited
대리인 / 주소	Brown Rudnick LLP
인용정보	피인용 횟수 : 0 인용 특허 : 175

초록 ▼

The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.

대표청구항 ▼

1. A method for analyzing a bacterium from a sample, the method comprising: providing a vessel that contains a body fluid sample comprising a bacterium;introducing to the sample in the vessel, magnetic particles comprising a bacterium-specific binding moiety and a buffer that promotes binding of the particles to the bacterium in order to create a mixture containing bacterium/magnetic particle complexes;flowing the mixture from the vessel into a fluidic device through a channel in the fluidic device and toward a magnet;applying a magnetic field to isolate the bacterium/magnetic particle complexes from the sample; andanalyzing the bacterium. 2. The method according to claim 1, further comprising washing with a wash solution that reduces particle aggregation. 3. The method according to claim 1, wherein the particles are superparamagnetic particles. 4. The method according to claim 3, wherein the particles have a diameter from about 100 nm to about 250 nm. 5. The method according to claim 4, wherein the particles are at least about 65% magnetic material by weight. 6. The method according to claim 1, wherein the bacterium-specific binding moiety is an antibody. 7. The method according to claim 6, wherein the antibody comprises a detectable label. 8. The method according to claim 1, wherein the body fluid is blood. 9. The method according to claim 8, wherein the bacterium is a blood borne bacterium. 10. The method according to claim 1, wherein identifying step comprises sequencing nucleic acid derived from the bacterium or amplifying nucleic acid derived from the bacterium. 11. The method of claim 1, wherein said buffer comprises sodium chloride. 12. The method of claim 11, wherein said buffer further comprises tri(hydroxymethyl)aminomethane-hydrochloric acid (Tris-HCl) and polysorbate 20. 13. The method of claim 12, wherein said Tris-HCl is concentration of about 75 mM. 14. The method of claim 1, wherein said buffer is present in said mixture at a ratio of about 1:1 with said sample. 15. The method of claim 1, wherein the fluidic device is a microfluidic device. 16. The method of claim 1, further comprising incubating the mixture in the vessel to allow the magnetic particles to bind to the bacterium and form bacterium/magnetic particle complexes. 17. A method for detecting a bacterium from a sample, the method comprising: providing a vessel that contains a body fluid sample comprising a bacterium;introducing to the sample in the vessel, magnetic particles comprising a bacterium-specific binding moiety and a buffer that promotes binding of the particles to the bacterium in order to create a mixture;incubating the mixture in the vessel to allow the particles to bind to the bacterium in the sample and form bacterium/magnetic particle complexes;flowing the mixture from the vessel into a fluidic device through a channel and toward a magnet;applying a magnetic field to isolate bacterium/magnetic particle complexes from the sample; anddetecting the bacterium.

이 특허에 인용된 특허 (175)

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Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
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Liberti Paul A. (Hungingdon Valley PA) Piccoli Steven P. (Morrisville PA), Process of making resuspendable coated magnetic particles.
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Terstappen Leon W. M. M. ; Liberti Paul A., Quantitative cell analysis methods employing magnetic separation.
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McElroy ; deceased Marlene D. (late of La Jolla CA) McElroy ; executor W. D. (San Diego CA) Helinski Donald R. (La Jolla CA) Wood Keith V. (San Diego CA) De Wet Jeffrey R. (Menlo Park CA) Ow David W., Recombinant expression of Coleoptera luciferase.
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McElroy ; deceased Marlene D. (late of La Jolle CA by William D. McElroy ; executor ) Helinski Donald R. (La Jolla CA) Wood Keith V. (Madison WI) De Wet Jeffrey R. (Pawcatuck CT) Ow David W. (Hercule, Recombinantly produced Coleoptera luciferase and fusion proteins thereof.
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Liberti Paul A. (Churchville PA) Pino Maria A. (Philadelphia PA), Resuspendable coated magnetic particles and stable magnetic particle suspensions.
상세보기

Tarnowski Thomas L. (South San Francisco CA) Lin Cheng-I (San Jose CA) Ullman Edwin F. (Atherton CA), Reversible agglutination mediators.
상세보기

Zeiger Heinz (Waldbronn DEX), Sample head for nuclear resonance measurements.
상세보기

Liberti, Paul A.; Pollara, Paul, Selective removal of immunospecifically recognizable substances from solution.
상세보기

Lapidus,Stanley N; Buzby,Philip Richard; Harris,Timothy, Short cycle methods for sequencing polynucleotides.
상세보기

Pyle Barry H. ; McFeters Gordon A., Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms.
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Josephson Lee (Arlington MA) Menz Edward T. (Quincy MA) Groman Ernest V. (Brookline MA), Solvent mediated relaxation assay system.
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Josephson Lee (Arlington MA) Menz Edward T. (Quincy MA) Groman Ernest V. (Brookline MA), Solvent mediated relaxation assay system.
상세보기

Theodore A. Dourdeville, Solvent susceptibility compensation for coupled LC-NMR.
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Peck, Tim L.; Olson, Dean; Norcross, Jim, Steep solvent gradient NMR analysis method.
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Rao Galla Chandra (Princeton NJ) Liberti Paul A. (Huntingdon Valley PA), Surface immobilization of magnetically collected materials.
상세보기

Nguyen, Justin T.; Chang, John; Chin, Stanley; Yang, Charles; Peltz, William R.; Loh, Helen; Thackery, Raymond; Han, Annie Bei; Kang, Betty Ku; Kuo, Glen Yan Kit, System and method for enterprise event marketing and management automation.
상세보기

Terstappen Leon W. M. M. (Palo Alto CA) Picker Louis J. (Dallas TX), T lymphocyte precursor.
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Terstappen Leon W. M. M. (Palo Alto CA) Picker Louis J. (Dallas TX), T lymphocyte precursor.
상세보기

Stackebrandt Erko (Daenischenhagen IL DEX) Curiale Michael (Homewood IL), Test for listeria.
상세보기

Gordon Julian ; Hoijer Joanell ; Jou Cynthia ; Rhoads James, Test strip having a diagonal array of capture spots.
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Barany Francis (New York NY) Zebala John (New York NY) Nickerson Deborah (Seattle WA) Kaiser ; Jr. Robert J. (Seattle WA) Hood Leroy (Seattle WA), Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease.
상세보기

Gerald, II,Rex E.; Meadows,Alexander D.; Gregar,Joseph S.; Rathke,Jerome W., Toroid cavity/coil NMR multi-detector.
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McDowell,Andrew F., Tuning low-inductance coils at low frequencies.
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Kagan,Michael; Rao,Galla Chandra; Prohaska,Jerry; Alden,Tor, Upon a cartridge for containing a specimen sample for optical analysis.
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Barbreau, Yves; Boulet, Olivier; Boulet, Arnaud; Delanoe, Alexis; Fauconnier, Laurence; Pelosin, Jean-Marc; Soufflet, Laurent, Use of ferrofluids for phenotyping blood and related applications.
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Murphy Timothy F., Vaccine for Moraxella catarrhalis.
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Finnigan James Patrick, Variable external capacitor for NMR probe.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Analyzing bacteria without culturing 원문보기

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연합인증

Analyzing bacteria without culturing 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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