Gas depletion and gas addition devices for blood treatment
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-019/00
A61N-001/02
A61M-001/02
A01N-001/02
출원번호
US-0771438
(2014-02-28)
등록번호
US-9877476
(2018-01-30)
국제출원번호
PCT/US2014/019537
(2014-02-28)
국제공개번호
WO2014/134503
(2014-09-04)
발명자
/ 주소
Levesque, Steven F.
Ruth, Thomas R
출원인 / 주소
New Health Sciences, Inc.
대리인 / 주소
Arnold & Porter Kaye Scholer
인용정보
피인용 횟수 :
0인용 특허 :
173
초록▼
Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorpora
Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.
대표청구항▼
1. A depletion device for removing a gas from a blood product comprising: a. an enclosure;b. one or more liquid chambers, wherein said one or more liquid chambers further comprise one or more flow control features that disrupt laminar flow;c. one or more depletion chambers;d. at least one gas permea
1. A depletion device for removing a gas from a blood product comprising: a. an enclosure;b. one or more liquid chambers, wherein said one or more liquid chambers further comprise one or more flow control features that disrupt laminar flow;c. one or more depletion chambers;d. at least one gas permeable barrier separating at least one of said one or more liquid chambers from said one or more depletion chambers;e. at least one liquid inlet;f. at least one liquid outlet; andg. a sorbent. 2. The depletion device of claim 1, wherein said gas permeable barrier is permeable to a gas selected from the group consisting of oxygen, carbon dioxide, and combinations thereof. 3. The depletion device of claim 1, wherein said at least one gas permeable barrier is a membrane comprising a polyolefin, polytetrafluoroethylene (PTFE), polyvinylidene mono- or di- fluoride (PVDF), a polysulfone, a silicone, an epoxy, a polyester membrane polyethylene, or a ceramic. 4. The depletion device of claim 3, wherein said at least one gas permeable barrier is a hydrophobic porous structure. 5. The depletion device of claim 1, wherein said one or more liquid chambers are separated from said one or more depletion chambers by more than one gas permeable barriers. 6. The depletion device of claim 1, wherein said one or more flow control features mix said blood product that enters through said at least one liquid inlet, flows through said one or more liquid chambers and exits through said at least one liquid outlet. 7. The depletion device of claim 1, wherein said blood product is selected from the group consisting of whole blood, leukocyte depleted blood, leukocyte and platelet depleted blood, a red blood cell suspension, and plasma. 8. The depletion device of claim 1, wherein said one or more depletion chambers further comprise at least one gas inlet and at least one gas outlet in fluid communication with said one or more depletion chambers. 9. The depletion device of claim 1, wherein said one or more liquid chambers is selected from the group consisting of one liquid chamber, two liquid chambers, three liquid chambers, four liquid chambers and five liquid chambers. 10. The depletion device of claim 1, wherein said one or more depletion chambers is selected from the group consisting of one depletion chamber, two depletion chambers, three depletion chambers, four depletion chambers, and five depletion chambers. 11. The depletion device of claim 1, wherein said one or more depletion chambers contain a depletion material selected from the group consisting of an oxygen depletion media, a carbon dioxide depletion media, and combinations thereof. 12. The depletion device of claim 11, wherein said depletion material is selected from the group consisting of a gel, a solid, a gas, and combinations thereof. 13. The depletion device of claim 1, wherein said enclosure is prepared of a material selected from the group consisting of a rigid material, a flexible material, an, elastic material, and combinations thereof. 14. The depletion device of claim 1, wherein said liquid chamber is prepared of a gas barrier material selected from the group consisting of a rigid material, a flexible material, an elastic material, and combinations thereof. 15. The depletion device of claim 1, further comprising an oxygen and carbon dioxide impermeable blood storage device connected to said liquid outlet. 16. The depletion device of claim 15, wherein said oxygen and carbon dioxide impermeable blood storage device further comprises an oxygen and carbon dioxide scavenger. 17. A method of depleting a gas from a blood product comprising flowing a liquid through a device according to claim 1 to prepare a gas depleted blood product. 18. The method of claim 17, wherein said gas depleted blood product is selected from the group consisting of whole blood, leukocyte depleted blood, leukocyte and platelet depleted blood, a red blood cell suspension, and plasma. 19. The method of claim 18, wherein said gas depleted blood product has a hemoglobin oxygen saturation of less than 10%. 20. The depletion device of claim 1, wherein said enclosure is a flexible enclosure having a single liquid chamber having one or more flow control features, two depletion chambers each having an oxygen depletion media, wherein said at least one gas permeable barrier comprises silicone. 21. The depletion device of claim 20, wherein said one or more flow control features are formed on said at least one gas permeable barrier. 22. The method of claim 18, wherein said gas depleted blood product has a hemoglobin oxygen saturation of less than 5%.
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