Nozzle for the supply of biological material, in particular cells, medical device with such a nozzle, use of a nozzle, method for mixing fluids and apparatus
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-031/00
A61M-037/00
A61M-025/00
B05B-001/34
B05B-007/04
B05B-007/10
B01F-005/00
B01F-013/00
A61B-017/00
출원번호
US-0054408
(2013-10-15)
등록번호
US-9878126
(2018-01-30)
우선권정보
EP-12188674 (2012-10-16)
발명자
/ 주소
Fech, Andreas
Fischer, Klaus
Enderle, Markus
Szyrach, Mara
출원인 / 주소
ERBE ELEKTROMEDIZIN GMBH
대리인 / 주소
Fitch, Even, Tabin & Flannery LLP
인용정보
피인용 횟수 :
0인용 특허 :
4
초록▼
A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), at least one nozzle opening (23) which is formed in the distal end
A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), at least one nozzle opening (23) which is formed in the distal end surface (22), and at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11). A first supply duct (30) is arranged in the proximal end surface (21) and discharges into the mixing chamber (11) coaxially to the nozzle opening (23) and a second supply duct (40) has an inlet opening (42) which discharges into the mixing chamber (11) laterally, in particular tangentially at the distal end surface (22).
대표청구항▼
1. Nozzle for the supply of biological material comprising: a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21),at least one nozzle opening (23) which is formed in the distal end surface (22),at least t
1. Nozzle for the supply of biological material comprising: a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21),at least one nozzle opening (23) which is formed in the distal end surface (22),at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11),a first supply duct (30) is arranged in the proximal end surface (21) and configured to discharge into the mixing chamber (11) coaxially to the nozzle opening (23), anda second supply duct (40) including an inlet opening (42) which discharges into the mixing chamber (11) laterally from and tangentially to an axis passing through the at least one nozzle opening (23) at the distal end surface (22) wherein the inlet opening (42) discharges into the mixing chamber (11) in a plane orthogonal to the axis passing through the at least one nozzle opening (23). 2. Nozzle according to claim 1, wherein the mixing chamber (11) has a length L which is at most 500 μm. 3. Nozzle according to claim 1, wherein the inlet opening (42) has a depth T which corresponds to length L of the mixing chamber (11). 4. Nozzle according to claim 1, wherein the distal end surface (22) of the mixing chamber (11) is arranged perpendicular to a longitudinal axis of the second supply duct (40). 5. Nozzle according to claim 1, wherein the inlet opening (42) has a rectangular cross-sectional profile or tapers in a direction of the mixing chamber (11). 6. Nozzle according to claim 5, wherein the inlet opening (42) has in particular two curved lateral surfaces (43, 44) which converge at the mixing chamber (11). 7. Nozzle according to claim 6, wherein an outer lateral surface (43) of the inlet opening (42) forms a continuous transition into an inner circumferential surface (12) of the mixing chamber (11). 8. Nozzle according to claim 1, further comprising at least one third supply duct (50) with an additional lateral inlet opening (52), which discharges laterally into the mixing chamber (11) at the distal end surface (22). 9. Nozzle according to claim 1, wherein one or more of the supply ducts (30, 40, 50), the mixing chamber (11), and the nozzle opening (23) are formed in one piece or several pieces. 10. Nozzle according to claim 1, wherein the supply ducts (30, 40, 50) are formed in a duct carrier (60) or the nozzle opening (23) is formed in a nozzle plate (20), wherein the mixing chamber (11) is formed in the nozzle plate (20) or in a mixing chamber plate (10) which is arranged between the nozzle plate (20) and the duct carrier (60). 11. Nozzle according to claim 1, further comprising at least one temperature control duct (90) configured to provide temperature control for a fluid flowing through at least one supply duct (30, 40, 50), wherein the temperature control duct (90) connects a supply line and a return line in such a manner that a closed temperature control circuit is formed. 12. Nozzle according to claim 1, further comprising at least an atomiser plate (80) connected distally to the nozzle plate (20) and having an atomiser opening (82) arranged coaxially to the nozzle opening (23), wherein at least one atomiser duct (81) is formed in the atomiser plate (80), connects the atomiser opening (82) to a gas supply duct (70) and preferably discharges tangentially into the atomiser opening (82). 13. Nozzle for medical purposes comprising: a mixing chamber (11), which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), andat least one nozzle opening (23) which is arranged in the distal end surface (22),wherein the mixing chamber (11) has a substantially cylindrical inner contour with at least two inlet openings (42, 52) which discharge into the mixing chamber (11) laterally from and tangentially to an axis passing through the at least one nozzle opening (23), which inlet openings (42, 52) are fluid-connected to a supply duct (40, 50),wherein the at least two inlet openings (42) discharge into the mixing chamber (11) in a plane orthogonal to the axis passing through the at least one nozzle opening (23), andwherein the inlet openings (42, 52) have different or the same cross-sectional surfaces. 14. Nozzle according to claim 13, wherein a cross-sectional surface of the inlet opening (42, 52) is formed to be smaller than a cross-sectional surface of the supply line (30). 15. Nozzle according to claim 13, wherein a ratio of the cross-sectional surfaces of the inlet openings (42, 52) corresponds to a ratio of volumetric flows of at least two fluids which flow with different or same volumetric flows into the mixing chamber (11), so that the fluids flow into the mixing chamber (11) with a substantially same average entry speed.
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