초록 ▼

The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing th

The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

대표청구항 ▼

1. A method for delivering an active ingredient to a living subject, comprising: a) obtaining a formulation of hydrophobic microparticles, the hydrophobic microparticles having a body, the body comprising a central part having an outer surface, wherein the outer surface is substantially hydrophobic,

1. A method for delivering an active ingredient to a living subject, comprising: a) obtaining a formulation of hydrophobic microparticles, the hydrophobic microparticles having a body, the body comprising a central part having an outer surface, wherein the outer surface is substantially hydrophobic,the central part and its substantially hydrophobic outer surface including a non-crosslinked carrier material throughout which is dispersed the active ingredient,wherein the non-crosslinked carrier material includes one or more of a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride;b) transferring the formulation of hydrophobic microparticles to a substrate; andc) placing the substrate in contact with the living subject;wherein the temperature, pH, or both of the living subject triggers progressive erosion of the substantially hydrophobic outer surface and the subsequent progressive erosion of the central part to release the non-crosslinked carrier material and the active ingredient for delivery to the living subject;wherein at least a portion of the substantially hydrophobic outer surface of the central part is exposed to the environment exterior to the hydrophobic microparticles when the substrate is in a pre-usage, stored state; andwherein the formulation optionally comprises a cationic surfactant, the cationic surfactant being present in the formulation, exterior to the microparticles. 2. A method as defined in claim 1, wherein friction between the substrate and the living subject further triggers the progressive erosion of the substantially hydrophobic outer surface and the subsequent progressive erosion of the central part of the body of the microparticle. 3. A method as defined in claim 1, wherein the substrate is composed of a material selected from the group consisting of woven materials, a non-woven materials, fibrous textiles, non-fibrous textile, fabrics, synthetic materials, papers and paper products, products made from composites, products made from polymers, products made from wood or wood by-products, products made from carbon fiber, products made from glass fiber and synthetic foam. 4. A method as defined in claim 1, wherein the non-crosslinked carrier material is caproic acid, caprylic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, a fatty acid derivative, tripalmitin, tristearin or glycerol monostearate or any combination thereof. 5. A method as defined in claim 1, wherein the non-crosslinked carrier material includes a fatty alcohol. 6. A method as defined in claim 1, wherein the non-crosslinked carrier material includes an emollient. 7. A method as defined in claim 1, wherein the formulation further comprises a binding agent. 8. A method as defined in claim 7, wherein the binding agent is a polyacrylic (PAC), a polyurethane (PU), a polysiloxane (POL), a polyvinylpyrrolidone (PVP), a guar gum or an acrylic base or any combination thereof. 9. A method as defined in claim 1, wherein one or more of the hydrophobic microparticles have a size in the range from about 0.1 μm and about 200 μm. 10. A method as defined in claim 1, wherein the hydrophobic microparticles have a melting temperature between about 20° C. and about 60° C. 11. A method as defined in claim 1, wherein the hydrophobic microparticles have a release index between 2 and 7. 12. A method as defined in claim 1, the body being entirely made of a mixture of the non-crosslinked carrier material and the active ingredient, wherein the non-crosslinked carrier material and the active ingredient are uniformly distributed throughout the body. 13. A method as defined in claim 1, wherein the hydrophobic microparticles have a melting temperature between 31° C. and 34.5° C. 14. A method as defined in claim 1, wherein the formulation of hydrophobic microparticles forms a perception indicator on the substrate. 15. A method as defined in claim 14, wherein the perception indicator is a) a visual indicator; b) a wear indicator; or c) a combination of a) and b). 16. The method of claim 1, wherein transferring the formulation of hydrophobic microparticles from the substrate to the living subject is effected by a dry transfer. 17. A method as defined in claim 1, wherein the active ingredient is a therapeutic agent. 18. A method as defined in claim 1, wherein the active ingredient is a cosmetic agent.