Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. A compressed filter device attached to a tether wire is loaded in the delivery tube. The access sheath and the delivery tube can be mechanically locked and
Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. A compressed filter device attached to a tether wire is loaded in the delivery tube. The access sheath and the delivery tube can be mechanically locked and moved together to place the device in a suitable deployment position. The device is deployed by expelling it from the delivery tube either by retracting the delivery tube over the tether wire, or by moving the tether wire forward through the delivery tube. A filter membrane in the deployed device extends across the appendage ostium to filter blood flow through the ostium. The filter membrane is configured to present a flat surface to atrial blood flow past the ostium.
대표청구항▼
1. A device configured for implantation in a left atrial appendage, the device comprising: a support structure having a proximal end, a distal end, and an intermediate portion extending between the proximal end and the distal end,wherein in an unconstrained condition diameters of the respective prox
1. A device configured for implantation in a left atrial appendage, the device comprising: a support structure having a proximal end, a distal end, and an intermediate portion extending between the proximal end and the distal end,wherein in an unconstrained condition diameters of the respective proximal end, distal end and intermediate portion of the support structure decrease distally over its longitudinal axis;a membrane extending along the intermediate portion and supported by the proximal end of the support structure,wherein the membrane is in a generally planar configuration along a plane at the proximal end of the support structure; anda plurality of tissue-engaging anchors disposed on the support structure distal of the membrane. 2. The device of claim 1, wherein the distal end of the support structure is an open end and the proximal end of the support structure is enclosed by the membrane. 3. The device of claim 1, wherein the plane is substantially perpendicular to a longitudinal axis of the device. 4. The device of claim 1, further comprising: a protrusion extending from adjacent the proximal end of the support structure,wherein the protrusion extends proximally from the plane. 5. The device of claim 4, wherein the protrusion comprise a threaded insert. 6. The device of claim 4, wherein the protrusion extends in a direction substantially perpendicular to the plane. 7. The device of claim 1, wherein the support structure comprises a proximal collar. 8. The device of claim 7, wherein the device includes a delivery configuration and a deployed configuration. 9. The device of claim 8, wherein the proximal collar is recessed and positioned distally of the plane when the device is in the deployed configuration. 10. The device of claim 1, wherein the support structure comprises: a plurality of struts defining a plurality of fenestrations and extending from the proximal end to the distal end of the support structure. 11. The device of claim 10, wherein the support structure comprises: a hub located near a radial center of the support structure; andwherein the plurality of struts extend from the hub. 12. The device of claim 10, wherein each strut of the plurality of struts forms an S-shape. 13. A system for implanting an implant in a left atrial appendage, the system comprising:a delivery catheter having an elongate flexible body with a proximal end and a distal end;a wire extending through the delivery catheter;an implant comprising:a support structure having a proximal end, a distal end, and an intermediate portion extending between the proximal end and the distal end,wherein in an unconstrained condition diameters of the support structure decrease distally over its longitudinal axis;a membrane extending along the intermediate portion and supported by the proximal end of the support structure; anda plurality of tissue-engaging anchors disposed on the support structure distal of the membrane,wherein the membrane is in a generally planar configuration along a plane at the proximal end of the support structure; andwherein a distal end of the wire is configured to be releasably attached to a proximal end of the implant. 14. The system of claim 13, wherein the distal end of the wire is configured to be releasable attached to a protrusion extending from adjacent a proximal end of the support structure, where the protrusion extends proximally from the plane. 15. The system of claim 14, wherein the protrusion extends in a direction substantially perpendicular to the plane. 16. The system of claim 13, wherein the distal end of the wire includes threads configured to engage threads on the proximal end of the implant. 17. The system of claim 13, wherein the plane is substantially perpendicular to a longitudinal axis of the support structure. 18. A blood filtration device for filtering blood flow from an atrial appendage, comprising: a proximal hub including a protrusion;a one-piece frame having a proximal end, a proximal portion, a distal portion, an intermediate portion between the proximal portion and the distal portion, and a distal end,wherein in an unconstrained condition diameters of the support structure decrease distally over its longitudinal axis;a blood-permeable membrane or mesh covering the proximal portion and at least a portion of the intermediate portion of the one-piece frame such that the blood-permeable membrane or mesh presents a generally planar surface; anda plurality of tissue-engaging anchors disposed on the support structure distal of the blood-permeable membrane,wherein the protrusion extends proximally from the generally planar surface. 19. The blood filtration device of claim 18, wherein the generally planar surface is substantially perpendicular to a longitudinal axis of the blood filtration device. 20. The blood filtration device of claim 18, wherein the protrusion extends in a direction substantially perpendicular to the generally planar surface.
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