[특허]Oncolytic rhabdovirus

Oncolytic rhabdovirus 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-007/00 A61K-045/06 A61K-035/766 A61K-035/768
출원번호	US-0696028 (2015-04-24)
등록번호	US-9896664 (2018-02-20)
발명자 / 주소	Bell, John C. Stojdl, David F.
출원인 / 주소	Turnstone Limited Partnership
대리인 / 주소	Borden Ladner Gervais LLP
인용정보	피인용 횟수 : 0 인용 특허 : 114

초록

Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.

대표청구항 ▼

1. An attenuated Maraba virus comprising: a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5. 2. A method of killing a hyperproliferative cell comprising contacting the cell with an isolated oncolytic Maraba virus encoding: a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5. 3. The method of claim 2, wherein the cell is comprised in a patient. 4. The method of claim 3, wherein the cell is a cancer cell. 5. The method of claim 4, wherein the cancer cell is a metastatic cancer cell. 6. The method of claim 3, wherein the oncolytic Maraba virus is administered to the patient. 7. The method of claim 6, wherein the oncolytic Maraba virus is administered by intraperitoneal, intravenous, intra-arterial, intramuscular, intradermal, intratumoral subcutaneous, or intranasal administration. 8. The method of claim 2, further comprising administering a second anti-cancer therapy. 9. The method of claim 8, wherein the second cancer therapy is chemotherapeutic, radiotherapeutic, or immunotherapeutic. 10. A method for treating a cancer patient comprising administering an effective amount of an isolated oncolytic Maraba virus encoding: a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5. 11. The method of claim 10, wherein the oncolytic Maraba virus is administered intraperitoneal, intravenous, intra-arterial, intramuscular, intradermal, intratumoral, subcutaneous, or intranasal administration. 12. The method of claim 10, further comprising administering a second cancer therapy. 13. The method of claim 12, wherein the second cancer therapy is chemotherapy, radiotherapy, immunotherapy, or surgery. 14. A composition comprising an isolated oncolytic Maraba virus having a nucleic acid segment encoding: a G protein having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5. 15. The composition of claim 14, wherein the composition is a pharmaceutically acceptable composition. 16. The composition of claim 15, further comprising a second anti-cancer agent. 17. The composition of claim 16, wherein the second anti-cancer agent is a chemotherapeutic, radiotherapeutic, or immunotherapeutic. 18. The attenuated Maraba virus of claim 1, wherein the G protein has an amino acid sequence that is 100% identical to the amino acid sequence of SEQ ID NO: 5 except for an arginine at the position corresponding to position 242 of SEQ ID NO: 5. 19. The method of claim 2, wherein the G protein has an amino acid sequence that is 100% identical to the amino acid sequence of SEQ ID NO: 5 except for an arginine at the position corresponding to position 242 of SEQ ID NO: 5. 20. The method of claim 10, wherein the G protein has an amino acid sequence that is 100% identical to the amino acid sequence of SEQ ID NO: 5 except for an arginine at the position corresponding to position 242 of SEQ ID NO: 5. 21. The composition of claim 14, wherein the G protein has an amino acid sequence that is 100% identical to the amino acid sequence of SEQ ID NO: 5 except for an arginine at the position corresponding to position 242 of SEQ ID NO: 5.

이 특허에 인용된 특허 (114)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Oncolytic rhabdovirus 원문보기

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Oncolytic rhabdovirus 원문보기

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대표청구항 ▼

연구과제 타임라인

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