Delivery device with separate chambers connectable in fluid communication when ready for use, and related method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B65B-003/00
A61J-007/00
B01F-011/00
B01F-015/02
B65D-075/52
B65D-081/32
B67D-003/00
A61J-001/20
A61J-001/10
출원번호
US-0637050
(2015-03-03)
등록번호
US-9902508
(2018-02-27)
발명자
/ 주소
Py, Daniel
출원인 / 주소
DR. PY INSTITUTE LLC
대리인 / 주소
McCarter & English, LLP
인용정보
피인용 횟수 :
0인용 특허 :
21
초록▼
A device and method are provided for storing substances separately, and for mixing the substances prior to use. The device defines at least one first chamber for receiving a first substance, and at least one second chamber for receiving a second substance. A first sealing portion is located between
A device and method are provided for storing substances separately, and for mixing the substances prior to use. The device defines at least one first chamber for receiving a first substance, and at least one second chamber for receiving a second substance. A first sealing portion is located between the first and second chambers and is movable between a closed position preventing fluid communication between the chambers, and an open position permitting fluid communication between the first and second chambers for mixing the substances. First and second penetrable and resealable portions in fluid communication with the first and second chamber(s), respectively, may be used for filling by penetrating them with an injection member and introduce the substances therethrough and into the respective chamber, and resealing the injection apertures and the substances within the respective chamber.
대표청구항▼
1. A method comprising: filling a device including a body defining at least one first chamber that is empty and sealed from the ambient atmosphere for receiving therein a first substance, and at least one second chamber that is empty and sealed from the ambient atmosphere for receiving therein a sec
1. A method comprising: filling a device including a body defining at least one first chamber that is empty and sealed from the ambient atmosphere for receiving therein a first substance, and at least one second chamber that is empty and sealed from the ambient atmosphere for receiving therein a second substance;at least one first sealing portion extending between the at least one first and second chambers in a closed position preventing fluid communication between the at least one first and second chambers, and transformable from the closed position to an open position permitting fluid communication between the at least one first and second chambers for mixing the first and second substances;a first penetrable and resealable portion in fluid communication with only the at least one first chamber and defining a hermetic seal between the at least one first chamber and the ambient atmosphere, wherein the first penetrable and resealable portion is penetrable by an injection member to form an injection aperture therethrough to aseptically introduce the first substance through the injection member and into the at least one first chamber while maintaining the hermetic seal between the at least one first chamber and the ambient atmosphere, and is resealable to hermetically seal the injection aperture and the first substance within the at least one first chamber; anda second penetrable and resealable portion in fluid communication with only the at least one second chamber and defining a hermetic seal between the at least one second chamber and the ambient atmosphere, wherein the second penetrable and resealable portion is penetrable by an injection member to form an injection aperture therethrough to aseptically introduce the second substance through the injection member and into the at least one second chamber while maintaining the hermetic seal between the at least one second chamber and the ambient atmosphere, and is resealable to hermetically seal the injection aperture and the second substance within the at least one second chamber;wherein the filling step includes introducing an injection member through the first penetrable and resealable portion;aseptically introducing a first substance through the injection member and into the at least one first chamber while maintaining a hermetic seal between the at least one first chamber and the ambient atmosphere;withdrawing the injection member;resealing a resulting injection aperture in the first penetrable and resealable portion and, in turn, hermetically sealing the first substance within the at least one first chamber;introducing an injection member through the second penetrable and resealable portion;aseptically introducing a second substance through the injection member and into the at least one second chamber while maintaining a hermetic seal between the at least one second chamber and the ambient atmosphere;withdrawing the injection member;and resealing a resulting injection aperture in the second penetrable and resealable portion and, in turn, hermetically sealing the second substance within the at least one second chamber. 2. A method as defined in claim 1, wherein the first substance is a medicament and the second substance is one or more of a food, a medicament, or a beverage. 3. A method as defined in claim 1, wherein the device further includes at least one dispensing port in fluid communication with one or more of the at least one first or second chambers, and a sealing member transformable from a closed position sealing the dispensing port and an open position allowing flow through the dispensing port, and the method further comprises (i) transforming the at least one first sealing portion between the closed position and the open position, thereby placing the at least one first chamber in fluid communication with the at least one second chamber;(ii) mixing the first and second substances;(iii) transforming the sealing member from the closed to the open position; and(iv) flowing the mixed first and second substances through the dispensing port. 4. A method as defined in claim 3, wherein device includes at least one substantially flexible portion defining at least a portion of one or more of the at least one first chamber or the at least one second chamber, and step (i) includes pressing the at least one substantially flexible portion or manually squeezing the body and causing one or more of the first substance or the second substance to exceed a threshold pressure that, in turn, causes the first sealing portion to transform from the closed position to the open position. 5. A method as defined in claim 2, further comprising the step of selecting the one or more of a food, a medicament, or a beverage to define one or more of (i) a substantially predetermined pH to control one or more of absorption, residence time, transport or bioavailability of the medicament in a mammal, (ii) at least one predetermined medicament metabolizing enzyme, (iii) at least one predetermined medicament transporting enzyme, (iv) at least one predetermined flavor, or (v) a predetermined viscosity of the beverage combined with the medicament. 6. A method as defined in claim 2, further comprising the step of selecting the one or more of a food, a medicament, or a beverage to define one or more of (i) a substantially predetermined pH to control absorption of the medicament in a target tissue of a mammal, or (ii) to substantially coat intestinal mucosa of a mammal to one or more of enhance tolerance of the medicament by, or reduce irritability of the medicament to, the mammal. 7. A method as defined in claim 2, further comprising the step of selecting the one or more of a food, a medicament, or a beverage based on the respective medicament to define a pH selected to achieve a substantially predetermined rate of absorption of the respective medicament in a mammal, a substantially predetermined residence time of the respective medicament in a stomach of the mammal, and a substantial tolerance of the respective medicament by the mammal. 8. A method as defined in claim 1, further comprising forming the body by providing first and second flexible sheets, and sealing one or more of the first or second flexible sheets to the other to define the at least one first and at least one second chambers therebetween. 9. A method as defined in claim 8, further comprising sealing opposing portions of one or more of the first or second sheets to the other to define at least one sealed portion and, in turn, forming a plurality of said at least one first chamber located on opposite sides of the at least one sealed portion relative to each other, and a plurality of said at least one second chamber located on opposite sides of the at least one sealed portion relative to each other, and preventing fluid communication between adjacent first chambers and adjacent second chambers. 10. A method as defined in claim 9, further comprising orienting the sheets substantially vertically during the sealing step. 11. A method as defined in claim 9, further comprising, prior to said sealing step, evenly distributing the first substance in said at least one first chamber, and evenly distributing the second substance in said at least one second chamber. 12. A method as defined in claim 1, further comprising removing the first penetrable and resealable portion and the second penetrable and resealable portion from the device after completing said filling step. 13. A method as defined in claim 12, further comprising, prior to said removing step, preventing fluid communication between the first penetrable and resealable portion and the at least one first chamber and between the second penetrable and resealable portion and the at least one second chamber. 14. A method as defined in claim 1, wherein the steps of resealing the injection aperture in the first penetrable and resealable portion and resealing the injection aperture in the second penetrable and resealable portion comprise applying radiation or energy thereto. 15. A method as defined in claim 14, wherein said resealing steps include thermally resealing the injection aperture in the first penetrable and resealable portion and the injection aperture in the second penetrable and resealable portion by applying laser radiation or energy. 16. A method as defined in claim 9, wherein the sealing step includes forming a plurality of individual delivery units, each having one of said plurality of first chambers and one of said plurality of second chambers. 17. A method as defined in claim 16, further comprising one or more of (a) removing one of said individual delivery units from the device; or (b) separating one of said individual delivery units from an adjacent one of said individual delivery units. 18. A method comprising: dispensing substance from a device including a body defining a plurality of first chambers each containing therein a first substance, and a plurality of respective second chambers each containing therein a second substance;a plurality of first sealing portions, each extending between one of the first chambers and its respective second chamber in a closed position preventing fluid communication therebetween, and transformable from the closed position to an open position permitting fluid communication therebetween for mixing the first and second substances; andat least one second sealing portion, each extending between adjacent of said first chambers and adjacent of said second chambers and preventing fluid communication therebetween, wherein the at least one second sealing portion defines the plurality of first chambers located on opposite sides of the at least one second sealing portion relative to each other, and the plurality of second chambers located on opposite sides of the at least one second sealing portion relative to each other;wherein the device defines a plurality of delivery devices, each delivery device including one of the plurality of first chambers, its respective second chamber, a respective one the plurality of first sealing portions; and a dispensing port in fluid communication with one or more of the respective first or second chambers thereof, and a third sealing portion transformable from a closed position sealing the respective dispensing port, and an open position allowing flow through the respective dispensing port; andfurther comprising a plurality of separable portions located between adjacent of said plurality of delivery devices adapted for separating said adjacent delivery devices from each other;wherein the dispensing step includes separating one of said delivery devices from any adjacent delivery devices at a respective separable portion;transforming the first sealing portion of said separated delivery device between the closed position and the open position, and placing the first chamber thereof in fluid communication with the second chamber thereof;mixing the first and second substances;transforming the third sealing portion of said separated delivery device from the closed to the open position; and flowing the mixed first and second substances through the dispensing port. 19. A method as defined in claim 18, wherein the step of transforming the first sealing portion includes pressurizing one or more of the first or second substances within its respective first or second chamber of said separated delivery device above a threshold pressure so as to, in turn, cause the first sealing portion to transform from the closed position to the open position. 20. A method as defined in claim 19, wherein the pressuring step includes squeezing or pressing one or more of the first or second chambers of the separated delivery device. 21. A method comprising: filling a device including a body defining at least one empty first chamber closed to the ambient atmosphere prior to filling and fillable while closed to contain a first substance therein sealed from the ambient atmosphere, and at least one empty second chamber closed to the ambient atmosphere prior to filling and fillable while closed to contain a second substance different from the first substance therein sealed from the ambient atmosphere;at least one first sealing portion extending between the at least one first and second chambers in a closed position preventing fluid communication between the at least one first and second chambers, and transformable from the closed position to an open position permitting fluid communication between the at least one first and second chambers for mixing the first substance and the second substance; andat least one dispensing port in fluid communication with one or more of the at least one first or second chambers, and at least one sealing member transformable from a closed position sealing the at least one dispensing port, and an open position allowing flow through the at least one dispensing port;wherein the filling step includes filling the at least one first chamber with the first substance while closed and filling the at least one second chamber with the second substance while closed. 22. A method as defined in claim 21, wherein the device further includes a first penetrable and resealable portion in fluid communication with only the at least one first chamber and defining a hermetic seal between the at least one first chamber and the ambient atmosphere, wherein the first penetrable and resealable portion is penetrable by an injection member to form an injection aperture therethrough and aseptically introduce the first substance through the injection member and into the at least one first chamber, and is resealable to hermetically seal the injection aperture and the first substance within the at least one first chamber; anda second penetrable and resealable portion in fluid communication with only the at least one second chamber and defining a hermetic seal between the at least one second chamber and the ambient atmosphere, wherein the second penetrable and resealable portion is penetrable by an injection member to form an injection aperture therethrough and aseptically introduce the second substance through the injection member and into the at least one second chamber, and is resealable to hermetically seal the injection aperture and the second substance within the at least one second chamber;wherein the step of filling the at least one first chamber includes introducing an injection member through the first penetrable and resealable portion;aseptically introducing the first substance through the injection member and into the at least one first chamber while maintaining the hermetic seal between the at least one first chamber and the ambient atmosphere;withdrawing the injection member; andresealing a resulting injection aperture in the first penetrable and resealable portion and, in turn, hermetically sealing the first substance within the at least one first chamber; andthe step of filling the at least one second chamber includes introducing an injection member through the second penetrable and resealable portion;aseptically introducing the second substance through the injection member and into the at least one second chamber while maintaining the hermetic seal between the at least one second chamber and the ambient atmosphere;withdrawing the injection member; andresealing a resulting injection aperture in the second penetrable and resealable portion and, in turn, hermetically sealing the second substance within the at least one second chamber. 23. A method as defined in claim 22, further including forming a seal between the first penetrable and resealable portion and the at least one first chamber and preventing fluid communication therebetween, and forming a seal between the second penetrable and resealable portion and the at least one second chamber and preventing fluid communication therebetween. 24. A method as defined in claim 23, further including removing the first and second penetrable and resealable portions from the device without exposing a respective at least one first or second chamber to the ambient atmosphere. 25. A method as defined in claim 21, further including transforming the at least one first sealing portion from the closed position to the open position and mixing the first and second substances. 26. A method as defined in claim 25, wherein the transforming step includes pressurizing one or more of the first or second substances within its respective at least one first or second chambers above a threshold pressure so as to cause the at least one first sealing portion to transform from the closed position to the open position. 27. A method as defined in claim 26, wherein the pressurizing step includes squeezing or pressing one or more of the at least one first or second chambers. 28. A method as defined in claim 25, further including transforming the at least one sealing member from the closed position to the open position, and flowing the mixed first and second substances through the at least one dispensing port. 29. A method as defined in claim 21, wherein the at least one first chamber defines a plurality of first chambers;the at least one second chamber defines a plurality of respective second chambers;the at least one first sealing portion defines a plurality of first sealing portions, each extending between one of said plurality of first chambers and its respective second chamber and preventing fluid communication therebetween;the at least one dispensing port defines a plurality of dispensing ports, each in fluid communication with one of the plurality of first chambers, its respective second chamber, or both;the at least one sealing member defines a plurality of sealing members, each adapted for sealing a respective one of said plurality of dispensing ports in its closed position;the step of filling the at least one first chamber includes filling the plurality of first chambers;the step of filling the at least one second chamber includes filling the plurality of second chambers; andthe method further includes forming a second sealing portion extending between adjacent of said plurality of first chambers and adjacent of said plurality of second chambers and, in turn, preventing fluid communication between (i) adjacent first chambers located on opposite sides of the second sealing portion relative to each other and (ii) adjacent second chambers located on opposite sides of the second sealing portion relative to each other, and defining a plurality of delivery devices, each delivery device including one of the plurality of first chambers, its respective second chamber, a respective one the plurality of first sealing portions; a respective one of the plurality of dispensing ports, and a respective one of the plurality of sealing members. 30. The method of claim 29, further including forming separable portions between adjacent of said plurality of delivery devices adapted for separating said adjacent delivery devices. 31. The method of claim 30, further including separating said adjacent delivery devices from each other.
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이 특허에 인용된 특허 (21)
Herb John R. (Bethlehem PA), Blood and blood component storage bags.
Loretti Maurice (Chatelaine CHX) Vanat Pierre (Geneva CHX) Andre Jacques (Annemasse FRX), Container intended for the separate storage of active compositions and for their subsequent mixing.
O\Reilly Daniel J. (‘Tara’Coney Weston Rd. Sapiston ; Suffolk GB3 1P31 1RX) Maloney John (9 Oakridge Wethenby GB3 LS22 4GT), Single use dispensing sachets and method of and means for manufacture of same.
Young J. Whitaker (Saint Michaels MD), Two-container system for mixing medicament with diluent including safety wand to protect against improper titration.
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