Convection enhanced delivery device and system
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-025/00
A61M-037/00
A61M-025/02
출원번호
US-0804427
(2015-07-21)
등록번호
US-9907941
(2018-03-06)
발명자
/ 주소
Vogelbaum, Michael A.
Gao, Shengqiang
Kolosi, William
출원인 / 주소
The Cleveland Clinic Foundation
대리인 / 주소
Tarolli, Sundheim, Covell & Tummino LLP
인용정보
피인용 횟수 :
0인용 특허 :
3
초록▼
A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by th
A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.
대표청구항▼
1. A convection enhanced delivery device comprising: (a) a flexible support member;(b) an elongated first microcatheter carried by the support member, the first microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the first microcatheter is
1. A convection enhanced delivery device comprising: (a) a flexible support member;(b) an elongated first microcatheter carried by the support member, the first microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the first microcatheter is disposed adjacent the support member and an opposite distal end of the first microcatheter is spaced apart from the support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter;(c) a first fluid conduit carried by the support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen;(d) an inlet port carried by the support member, the inlet port being in fluid communication with the first fluid conduit such that fluid supplied to the inlet port is delivered by the inlet port to the first fluid conduit, the inlet port being presented outwardly of and away from the support member in a third direction different than the first direction, the inlet port being configured to engage an end portion of a first external fluid conduit such that fluid is supplied to the inlet port by the first external fluid conduit and such that the first external fluid conduit projects away from the inlet port and from the support member, the inlet port being disposed adjacent a first external surface of the support member presented outwardly of and away from the support member; and(e) a connecting port carried by the support member and separate from the inlet port, the connecting port being in fluid communication with the first fluid conduit such that fluid is delivered by the first fluid conduit to the connecting port, the connecting port being presented outwardly of and away from the support member in a fourth direction different than the first direction, the connecting port being configured to engage an end portion of a second external fluid conduit such that fluid delivered to the connecting port is delivered by the connecting port to the second external fluid conduit and such that the second external fluid conduit projects away from the connecting port and from the support member, the connecting port being disposed at or outwardly beyond a second external surface of the support member presented outwardly of and away from the support member. 2. A convection enhanced delivery device according to claim 1 wherein the first fluid conduit is embedded in the support member. 3. A convection enhanced delivery device according to claim 1 wherein the first fluid conduit is formed in the support member. 4. A convection enhanced delivery device according to claim 1 further comprising a second fluid conduit carried by the support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a fifth direction different than the first direction and the second direction, the second conduit lumen being in fluid communication with the first conduit lumen. 5. A convection enhanced delivery device according to claim 1 further comprising (f) an elongated second microcatheter carried by the support member, the second microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the second microcatheter is disposed adjacent the support member and an opposite distal end of the second microcatheter is spaced apart from the support member, the second microcatheter including a second catheter lumen extending in a fifth direction lengthwise of the second microcatheter; and(g) a second fluid conduit carried by the support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a sixth direction different than the first direction and the second direction, the second conduit lumen being in fluid communication with the second catheter lumen. 6. A convection enhanced delivery device according to claim 5 wherein the first conduit lumen is in fluid communication with the second conduit lumen. 7. A convection enhanced delivery device according to claim 1 wherein the support member includes a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue of a patient. 8. A kit of components for a convection enhanced delivery system comprising at least two convection enhanced delivery devices and at least one external connecting fluid conduit for interconnecting said at least two convection enhanced delivery devices, each convection enhanced delivery device comprising: (a) a flexible support member;(b) an elongated microcatheter carried by the support member, the microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the microcatheter is disposed adjacent the support member and an opposite distal end of the microcatheter is spaced apart from the support member, the microcatheter including a catheter lumen extending in a first direction lengthwise of the microcatheter;(c) a first fluid conduit carried by the support member, the first fluid conduit including a conduit lumen, the conduit lumen extending in a second direction different than the first direction, the conduit lumen being in fluid communication with the catheter lumen;(d) an inlet port carried by the support member, the inlet port being in fluid communication with the first fluid conduit such that fluid supplied to the inlet port is delivered by the inlet port to the first fluid conduit, the inlet port being presented outwardly of and away from the support member in a third direction different than the first direction, the inlet port being configured to engage an end portion of a first external fluid conduit such that fluid is supplied to the inlet port by the first external fluid conduit and such that the first external fluid conduit projects away from the inlet port and from the support member, the inlet port being disposed adjacent a first external surface of the support member presented outwardly of and away from the support member; and(e) a connecting port carried by the support member and separate from the inlet port, the connecting port being in fluid communication with the first fluid conduit such that fluid is delivered by the first fluid conduit to the connecting port, the connecting port being presented outwardly of and away from the support member in a fourth direction different than the first direction, the connecting port being configured to engage an end portion of the at least one external connecting fluid conduit such that fluid delivered to the connecting port is delivered by the connecting port to the at least one external connecting fluid conduit and such that the at least one external connecting fluid conduit projects away from the connecting port and from the support member, the connecting port being disposed at or outwardly beyond a second external surface of the support member presented outwardly of and away from the support member. 9. A kit of components for a convection enhanced delivery system according to claim 8 further comprising a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support the support member of at least one of the convection enhanced delivery devices while permitting the microcatheter carried by the support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 10. A kit of components according to claim 8 wherein the support member of each convection enhanced delivery device includes a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue of a patient. 11. A convection enhanced delivery system comprising: (a) first, second, and third external fluid conduits;(b) a first convection enhanced delivery device comprising (i) a flexible first support member,(ii) an elongated first microcatheter carried by the first support member, the first microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the first microcatheter is disposed adjacent the first support member and an opposite distal end of the first microcatheter is spaced apart from the first support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter,(iii) a first fluid conduit carried by the first support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen,(iv) a first inlet port carried by the first support member, the first inlet port being in fluid communication with the first fluid conduit such that fluid supplied to the first inlet port is delivered by the first inlet port to the first fluid conduit, the first inlet port being presented outwardly of and away from the first support member in a third direction different than the first direction, the first inlet port engaging an end portion of the first external fluid conduit such that fluid is supplied to the first inlet port by the first external fluid conduit and such that the first external fluid conduit projects away from the first inlet port and from the first support member, the first inlet port being disposed adjacent a first external surface of the first support member presented outwardly of and away from the first support member, and(v) a first connecting port carried by the first support member and separate from the first inlet port, the first connecting port being in fluid communication with the first fluid conduit such that fluid is delivered by the first fluid conduit to the first connecting port, the first connecting port being presented outwardly of and away from the first support member in a fourth direction different than the first direction, the first connecting port engaging a first end portion of the second external fluid conduit such that fluid delivered to the first connecting port is delivered by the first connecting port to the second external fluid conduit and such that the second external fluid conduit projects away from the first connecting port and from the first support member, the first connecting port being disposed at or outwardly beyond a second external surface of the first support member presented outwardly of and away from the first support member; and(c) a second convection enhanced delivery device comprising (i) a flexible second support member,(ii) an elongated second microcatheter carried by the second support member, the second microcatheter having a length and projecting lengthwise away from the second support member such that a proximal end of the second microcatheter is disposed adjacent the second support member and an opposite distal end of the second microcatheter is spaced apart from the second support member, the second microcatheter including a second catheter lumen extending in a fifth direction lengthwise of the second microcatheter,(iii) a second fluid conduit carried by the second support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a sixth direction different than the fifth direction, the second conduit lumen being in fluid communication with the second catheter lumen,(iv) a second inlet port carried by the second support member, the second inlet port being in fluid communication with the second fluid conduit such that fluid supplied to the second inlet port is delivered by the second inlet port to the second fluid conduit, the second inlet port being presented outwardly of and away from the second support member in a seventh direction different than the fifth direction, the second inlet port engaging a second end portion of the second external fluid conduit such that fluid is supplied to the second inlet port by the second external fluid conduit and such that the second external fluid conduit projects away from the second inlet port and from the second support member, the second inlet port being disposed adjacent a first external surface of the second support member presented outwardly of and away from the second support member, and(v) a second connecting port carried by the second support member and separate from the second inlet port, the second connecting port being in fluid communication with the second fluid conduit such that fluid is delivered by the second fluid conduit to the second connecting port, the second connecting port being presented outwardly of and away from the second support member in an eighth direction different than the fifth direction, the second connecting port engaging an end portion of the third external fluid conduit such that fluid delivered to the second connecting port is delivered by the second connecting port to the third external fluid conduit and such that the third external fluid conduit projects away from the second connecting port and from the second support member, the second connecting port being disposed at or outwardly beyond a second external surface of the second support member presented outwardly of and away from the second support member. 12. A convection enhanced delivery system according to claim 11, wherein the first convection enhanced delivery device further comprises (vi) an elongated third microcatheter carried by the first support member, the third microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the third microcatheter is disposed adjacent the first support member and an opposite distal end of the third microcatheter is spaced apart from the first support member, the third microcatheter including a third catheter lumen extending in a ninth direction lengthwise of the third microcatheter; and(vii) a third fluid conduit carried by the first support member, the third fluid conduit including a third conduit lumen, the third conduit lumen extending in a tenth direction different than the second direction, the third conduit lumen being in fluid communication with the third catheter lumen. 13. A convection enhanced delivery device according to claim 12 wherein the first conduit lumen is in fluid communication with the third conduit lumen. 14. A convection enhanced delivery system according to claim 11 further comprising a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support at least one of the first and second support members while permitting at least one of the first microcatheter and the second microcatheter carried by said at least one of the first and second support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 15. A convection enhanced delivery system according to claim 14, wherein at least one of the first and second convection enhanced delivery devices also comprises an attachment mechanism configured to attach said at least one of the first and second convection enhanced delivery devices to the mesh support structure, the attachment mechanism including at least one leg configured and dimensioned to directly engage at least one cross member of the mesh support structure. 16. A convection enhanced delivery system according to claim 11 wherein each of the first and second support members includes a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue of a patient. 17. A convection enhanced delivery system comprising: (a) a first convection enhanced delivery device comprising (i) a flexible first support member,(ii) an elongated first microcatheter carried by the first support member, the first microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the first microcatheter is disposed adjacent the first support member and an opposite distal end of the first microcatheter is spaced apart from the first support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter, and(iii) a first inlet port carried by the first support member, the first inlet port being in fluid communication with the first microcatheter, the first inlet port being presented outwardly of and away from the first support member in a second direction different than the first direction, the first inlet port being configured to engage an end portion of a first external fluid conduit such that fluid is supplied to the first inlet port by the first external fluid conduit and such that the first external fluid conduit projects away from the first inlet port and from the first support member, the first inlet port being disposed adjacent a first external surface of the first support member presented outwardly of and away from the first support member; and(b) a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support the first support member of the first convection enhanced delivery device while permitting the first microcatheter carried by the first support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 18. A convection enhanced delivery system according to claim 17, wherein the first convection enhanced delivery device further comprises: (iv) a first fluid conduit carried by the first support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a third direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen, and(v) a first connecting port carried by the first support member and separate from the first inlet port, the first connecting port being in fluid communication with the first fluid conduit such that fluid is delivered by the first fluid conduit to the first connecting port, the first connecting port being presented outwardly of and away from the first support member in a fourth direction different than the first direction, the first connecting port being configured to engage a first end portion of a second external fluid conduit such that fluid delivered to the first connecting port is delivered by the first connecting port to the second external fluid conduit and such that the second external fluid conduit projects away from the first connecting port and from the first support member, the first connecting port being disposed at or outwardly beyond a second external surface of the first support member presented outwardly of and away from the first support member. 19. A convection enhanced delivery system according to claim 17, wherein the first convection enhanced delivery device also comprises an attachment mechanism configured to attach the first convection enhanced delivery device to the mesh support structure, the attachment mechanism including at least one leg configured and dimensioned to directly engage at least one cross member of the mesh support structure. 20. A convection enhanced delivery system according to claim 17, further comprising: (c) a second convection enhanced delivery device comprising (i) a flexible second support member,(ii) an elongated second microcatheter carried by the second support member, the second microcatheter having a length and projecting lengthwise away from the second support member such that a proximal end of the second microcatheter is disposed adjacent the second support member and an opposite distal end of the second microcatheter is spaced apart from the second support member, the second microcatheter including a second catheter lumen extending in a third direction lengthwise of the second microcatheter, and(iii) a second inlet port carried by the second support member, the second inlet port being in fluid communication with the second microcatheter, the second inlet port being presented outwardly of and away from the second support member in a fourth direction different than the third direction, the second inlet port being configured to engage an end portion of a second external fluid conduit such that fluid is supplied to the second inlet port by the second external fluid conduit and such that the second external fluid conduit projects away from the second inlet port and from the second support member, the second inlet port being disposed adjacent a first external surface of the second support member presented outwardly of and away from the second support member, the mesh support structure being configured and dimensioned to support the second support member of the second convection enhanced delivery device while permitting the second microcatheter carried by the second support member to extend through at least one of the openings defined in the mesh support structure by the cross members.
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