[특허]Nozzles for nasal drug delivery

Nozzles for nasal drug delivery 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-015/08 A61M-015/00 A61M-016/12 B05B-007/08 B05B-001/14 A61M-016/20
출원번호	US-0075126 (2013-11-08)
등록번호	US-9919117 (2018-03-20)
발명자 / 주소	Hoekman, John D. Hite, Michael Brunelle, Alan Relethford, Joel
출원인 / 주소	IMPEL NEUROPHARMA INC.
대리인 / 주소	Fenwick & West LLP
인용정보	피인용 횟수 : 0 인용 특허 : 139

초록 ▼

A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

대표청구항 ▼

1. A nozzle for delivering an intranasal dosage form comprising: a distal and a proximal end of the nozzle,a drug product inlet in fluid connection with the proximal end of the nozzle and configured to receive a mixture of a propellant and the intranasal dosage form,a nozzle body defining five channels, each of the five channels having a proximal end and a distal end, the nozzle body defining a longitudinal axis,a circular outlet orifice disposed at the distal end of each of the five channels forming five outlet orifices arranged in a pentagon, anda container containing a propellant in fluid communication with the drug product inlet, the propellant configured to propel the intranasal dosage form from the drug product inlet through the channels and out the outlet orifices,each of the five channels configured to generate a stream of intranasal dosage form during a delivery time course which streams form a narrow plume once exited the outlet orifices, wherein an angle of the narrow plume is about 5 degrees, about 4 degrees, about 3 degrees, about 2 degrees, about 1 degree, or about 0 degree. 2. The nozzle of claim 1 wherein the channels are disposed parallel to the longitudinal axis. 3. The nozzle of claim 1, wherein the channels are a plastic or a metal, the nozzle body is a plastic or a metal, and a void is disposed between the channels and the nozzle body. 4. The nozzle of claim 1, wherein the angle of the narrow plume is about 5 degrees. 5. The nozzle of claim 1 wherein an impact force delivered by the nozzle is decreased. 6. The nozzle of claim 1, wherein a delivery time for the intranasal dosage form is decreased. 7. The nozzle of claim 1 wherein the delivery time course is measured over a span of 4 cm from the outlet orifices. 8. The nozzle of claim 7 wherein the delivery time course is measured using high speed blotter recording. 9. The nozzle of claim 1, wherein the narrow plume once exited the outlet orifices during the delivery time course measured 4 cm from the outlet orifices of the nozzle has a principle deposition zone of less than 3 mm. 10. The nozzle of claim 1 wherein the channels are disposed at an angle with respect to the longitudinal axis. 11. The nozzle of claim 1, wherein drug product inlet is contiguous with the proximal end of the nozzle. 12. A method for delivering a drug product to an olfactory region of a nasal cavity, the method comprising: providing a nozzle, the nozzle having a proximal end and a distal end, a drug product inlet in fluid connection with the proximal end of the nozzle and configured to receive a mixture of a propellant and the drug product, five channels contiguous with the drug product inlet and with five circular outlet orifices arranged in a pentagon at the distal end of the nozzle, each channel for carrying the drug product;providing a container containing a propellant in fluid communication with the drug product inlet of the nozzle, the propellant configured to propel the drug product from the drug product inlet though the channels and out the five circular outlet orifices;providing a drug product at the drug product inlet of the nozzle; anddispensing the propellant to propel the drug product from the drug product inlet through the channels and out the five circular outlet orifices;wherein each of the five channels generates a corresponding stream of drug product that together form a narrow drug plume upon exiting distal end of the nozzle, wherein an angle of the narrow drug plume is about 5 degrees, about 4 degrees, about 3 degrees, about 2 degrees, about 1 degree, or about 0 degree. 13. The method of claim 12, wherein the drug product is a liquid or powder. 14. The method of claim 12, wherein the drug product inlet is contiguous with the proximal end of the nozzle.

이 특허에 인용된 특허 (139)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Nozzles for nasal drug delivery 원문보기

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Nozzles for nasal drug delivery 원문보기

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AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

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