Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08J-003/24
C08K-005/1545
A61L-027/16
A61L-027/50
A61B-017/80
A61L-031/04
A61L-031/14
C08J-003/28
C08L-023/06
출원번호
US-0983006
(2015-12-29)
등록번호
US-9926432
(2018-03-27)
발명자
/ 주소
Rufner, Alicia
Knight, John
Rowe, Toni
Pletcher, Dirk
Gsell, Ray
Brinkerhuff, Hallie E
Schneider, Werner
출원인 / 주소
Zimmer, Inc.
대리인 / 주소
Schwegman Lundberg & Woessner, P.A.
인용정보
피인용 횟수 :
1인용 특허 :
79
초록▼
An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate
An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
대표청구항▼
1. A method for preparing an antioxidant-stabilized crosslinked UHMWPE blend for use in medical implants, the method comprising: preheating a consolidated blend to a preheat temperature below the melting point of the consolidated blend, the consolidated blend comprising UHMWPE and about 0.1 wt % to
1. A method for preparing an antioxidant-stabilized crosslinked UHMWPE blend for use in medical implants, the method comprising: preheating a consolidated blend to a preheat temperature below the melting point of the consolidated blend, the consolidated blend comprising UHMWPE and about 0.1 wt % to about 3.0 wt % antioxidant, wherein the preheating comprises preheating to a temperature of greater than room temperature to about 140° C.; andirradiating the preheated consolidated blend that has a temperature of greater than room temperature to about 140° C. with a total absorbed dose of about 50 kGy to about 250 kGy while maintaining the consolidated blend at a temperature below the melting point of the consolidated blend to form the antioxidant-stabilized crosslinked UHMWPE blend, wherein the irradiating is electron beam irradiating performed in a single pass. 2. The method of claim 1, wherein the preheating comprises preheating to a temperature of about 70° C. to about 130° C. 3. The method of claim 1, wherein the preheating comprises preheating to a temperature of about 40° C. to about 120° C. 4. The method of claim 1, wherein the antioxidant is substantially homogeneously distributed in the antioxidant-stabilized crosslinked UHMWPE blend. 5. The method of claim 1, wherein the antioxidant is tocopherol, or a salt or ester thereof. 6. The method of claim 5, wherein the tocopherol is d,l-α-tocopherol or an acetate ester thereof. 7. The method of claim 1, wherein the crosslinked UHMWPE blend has a pin-on-disc wear rate of less than 2.75 mg/Mc. 8. The method of claim 1, wherein the crosslinked UHMWPE blend has a pin-on-disc wear rate of about 0.02 mg/Mc to about 0.69 mg/Mc. 9. The method of claim 1, wherein the crosslinked UHMWPE blend has a pin-on-disc wear rate of about 0.02 mg/Mc to about 0.58 mg/Mc. 10. The method of claim 1, wherein the crosslinked UHMWPE blend has a tensile yield strength of at least 21 mega pascals. 11. The method of claim 1, wherein the crosslinked UHMWPE blend has an ultimate tensile strength of at least 45 mega pascals. 12. The method of claim 1, wherein the crosslinked UHMWPE blend has an izod impact strength of at least 53 kJ/m2. 13. The method of claim 1, further comprising molding the crosslinked UHMWPE blend into at least one of a substrate, a polymer article, and an antioxidant-stabilized polymer article. 14. The method of claim 1, wherein the crosslinked UHMWPE blend has an oxidation index of less than 0.10. 15. The method of claim 1, wherein the crosslinked UHMWPE blend has an oxidation index that remains below 0.1 after accelerated aging for two weeks in an oxygen atmosphere at a pressure of 72 pounds per square inch and a temperature of 70° C. 16. The method of claim 1, further comprising annealing the crosslinked UHMWPE blend after the irradiating. 17. The method of claim 1, further comprising consolidating a blend comprising UHMWPE and about 0.1 wt % to about 3.0 wt % of the antioxidant, to form the consolidated blend. 18. The method of claim 17, further comprising combining UHMWPE with the antioxidant to provide the blend comprising UHMWPE and the antioxidant that is subsequently consolidated.
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이 특허에 인용된 특허 (79)
Rufner, Alicia; Knight, John; Rowe, Toni; Pletcher, Dirk; Gsell, Ray; Schneider, Werner; Brinkerhuff, Hallie E, Antioxidant stabilized crosslinked ultra high molecular weight polyethylene for medical device applications.
Thomas, Brian H.; Acker, Dean M.; Gsell, Ray; Stark, Norman, Crosslinked polymers including one or more antioxidants, methods for making same and methods for selecting antioxidants.
Merrill Edward W. ; Harris William H. ; Venugopalan Premnath ; Jasty Murali ; Bragdon Charles R. ; O'Connor Daniel O., Melt-irradiated ultra high molecular weight polyethylene prosthetic devices.
Hamilton John V. (Foxborough MA) Manasas Mark A. (South Easton MA) Flynn Timothy M. (Norton MA), Method for improving wear resistance of polymeric bioimplantable components.
Lars Lidgren SE; Peter Bengtsson SE; Peter Sj{overscore (o)}vall SE; Bengt Wesslen SE, Method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof.
Burstein, Albert H., Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof.
Saum Kenneth Ashley ; Sanford William Michael ; DiMaio ; Jr. William Gerald ; Howard ; Jr. Edward George, Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance.
Saum Kenneth Ashley ; Sanford William Michael ; Dimaio ; Jr. William Gerald ; Howard ; Jr. Edward George, Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance.
Saum, Kenneth Ashley; Sanford, William Michael; Dimaio, Jr., William Gerald; Howard, Jr., Edward George, Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance.
Burstein Albert H. ; Li Stephen, Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and.
Edward W. Merrill ; William H. Harris ; Premnath Venugopalan ; Murali Jasty ; Charles R. Bragdon ; Daniel O. O'Connor, Process of making ultra high molecular weight polyethylene prosthetic devices.
Merrill, Edward W.; Harris, William H.; Jasty, Murali; Muratoglu, Orhun; Bragdon, Charles R.; O'Connor, Daniel O.; Venugopalan, Premnath, Radiation and melt treated ultra high molecular weight polyethylene prosthetic device and method.
Merrill, Edward W.; Harris, William H.; Jasty, Murali; Muratoglu, Orhun; Bragdon, Charles R.; O'Connor, Daniel O.; Venugopalan, Premnath, Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices.
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