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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0473733 (2017-03-30) |
등록번호 | US-9931349 (2018-04-03) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 561 |
This disclosure provides a novel pharmaceutical composition for delivering steroid hormones to a patient in need thereof.
1. A pharmaceutical composition suitable for administering a steroid hormone to a subject in need thereof, the pharmaceutical composition comprising a steroid hormone, a lipophilic surfactant system comprising a first lipophilic surfactant and a second lipophilic surfactant, wherein the first and se
1. A pharmaceutical composition suitable for administering a steroid hormone to a subject in need thereof, the pharmaceutical composition comprising a steroid hormone, a lipophilic surfactant system comprising a first lipophilic surfactant and a second lipophilic surfactant, wherein the first and second lipophilic surfactants are different from each other, a hydrophilic surfactant system comprising first and second hydrophilic surfactants, and an optional terpene, wherein the pharmaceutical composition is completely or substantially free of fractionated vegetable oils. 2. The pharmaceutical composition of claim 1, wherein the first lipophilic surfactant is a first partial triglyceride and wherein the second lipophilic surfactant is a second partial triglyceride. 3. The pharmaceutical composition of claim 2, wherein the first and second partial triglycerides are selected from the group consisting of IMWITOR 988, IMWITOR 742, IMWITOR 308, CAPMUL MCM NF, CAPMUL 708G, and glyceryl dilaurate. 4. The pharmaceutical composition of claim 3, wherein the first partial triglyceride is CAPMUL MCM NF and the second partial triglyceride is CAPMUL 708G and wherein the first hydrophilic surfactant is a polyoxyethylene sorbitan fatty acid derivative. 5. The pharmaceutical composition of claim 4, wherein the polyoxyethylene sorbitan fatty acid derivative is TWEEN 20 or TWEEN 80. 6. The pharmaceutical composition of claim 4, wherein the second hydrophilic surfactant is a castor oil or hydrogenated castor oil ethoxylate. 7. The pharmaceutical composition of claim 6, wherein the castor oil or hydrogenated castor oil ethoxylate is CREMOPHOR EL, CREMOPHOR RH40, ETOCAS 40, CRODURET 60, or KOLLIPHOR HS 15. 8. The pharmaceutical composition of claim 7, wherein the castor oil or hydrogenated castor oil ethoxylate is CREMOPHOR RH40. 9. The pharmaceutical composition of claim 1, wherein the second hydrophilic surfactant is TPGS. 10. The pharmaceutical composition of claim 1, wherein the terpene is not optional and is d-limonene. 11. The pharmaceutical composition of claim 1, wherein the steroid hormone is progesterone and wherein the progesterone is fully solubilized. 12. A method of treating a disease or condition associated with reduced progesterone levels, the method comprising administering to a subject in need thereof a pharmaceutical composition according to claim 1. 13. The method of claim 12, wherein the first lipophilic surfactant is a first partial triglyceride and wherein the second lipophilic surfactant is a second partial triglyceride. 14. The method of claim 13, wherein the first and second partial triglycerides are selected from the group consisting of IMWITOR 988, IMWITOR 742, IMWITOR 308, CAPMUL MCM NF, CAPMUL 708G, and glyceryl dilaurate. 15. The method of claim 14, wherein the first partial triglyceride is CAPMUL MCM NF and the second partial triglyceride is CAPMUL 708G and wherein the first hydrophilic surfactant is a polyoxyethylene sorbitan fatty acid derivative. 16. The method of claim 15, wherein the polyoxyethylene sorbitan fatty acid derivative is TWEEN 20 or TWEEN 80. 17. The method of claim 15, wherein the second hydrophilic surfactant is a castor oil or hydrogenated castor oil ethoxylate. 18. The method of claim 17, wherein the castor oil or hydrogenated castor oil ethoxylate is CREMOPHOR EL, CREMOPHOR RH40, ETOCAS 40, CRODURET 60, or KOLLIPHOR HS 15. 19. The method of claim 18, wherein the castor oil or hydrogenated castor oil ethoxylate is CREMOPHOR RH40. 20. The method of claim 15, wherein the second hydrophilic surfactant is TPGS. 21. The method of claim 12, wherein the terpene is not optional and is d-limonene. 22. The method of claim 12, wherein the disease or condition associated with reduced progesterone levels is selected from the group consisting of menopause, endometrial hyperplasia; secondary amenorrhea; prevention of preterm birth; and osteoporosis.
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