Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/085
A61P-037/04
C07K-014/31
A61K-038/00
출원번호
US-0142524
(2010-03-23)
등록번호
US-9932373
(2018-04-03)
국제출원번호
PCT/US2010/028326
(2010-03-23)
§371/§102 date
20110927
(20110927)
국제공개번호
WO2010/111273
(2010-09-30)
발명자
/ 주소
Herron-Olson, Lisa L.
Catron, Drew M.
출원인 / 주소
EPITOPIX, LLC
대리인 / 주소
Mueting, Raasch & Gebhardt, PA
인용정보
피인용 횟수 :
0인용 특허 :
35
초록
The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
대표청구항▼
1. A composition comprising: an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:397, with the proviso that if the isolated polypeptide includes additional amino acids at the amino terminal, the additional amino acids include at least two amino acid modifications compared to amin
1. A composition comprising: an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:397, with the proviso that if the isolated polypeptide includes additional amino acids at the amino terminal, the additional amino acids include at least two amino acid modifications compared to amino acids 1-26 of SEQ ID NO:399, wherein the at least two amino acid modifications comprise: at least two amino acid substitutions;at least two amino acid deletions; orat least one amino acid substitution and at least one amino acid deletion; andan effective amount of a pharmaceutically acceptable adjuvant. 2. The composition of claim 1 further comprising a pharmaceutically acceptable carrier. 3. The composition of claim 1 further comprising at least one second polypeptide, wherein the second polypeptide is isolatable from a Staphylococcus aureus when incubated in culture media comprising an iron chelator and not isolatable when grown in the culture media without the iron chelator. 4. The composition of claim 3 wherein the second polypeptide comprises an amino acid sequence having at least 95% similarity to the amino acid sequence of any one of SEQ ID NO: 353, SEQ ID NO: 354, SEQ ID NO: 355, SEQ ID NO: 356, SEQ ID NO: 357, SEQ ID NO: 358, SEQ ID NO: 359, SEQ ID NO: 360, SEQ ID NO: 361, SEQ ID NO: 362, SEQ ID NO: 363, SEQ ID NO: 364, SEQ ID NO: 365, SEQ ID NO: 366, SEQ ID NO: 367, SEQ ID NO: 368, SEQ ID NO: 369, SEQ ID NO: 370, SEQ ID NO: 371, SEQ ID NO: 372, SEQ ID NO: 373, SEQ ID NO: 374, SEQ ID NO: 375, SEQ ID NO: 376, SEQ ID NO: 377, SEQ ID NO: 378, SEQ ID NO: 379, SEQ ID NO: 380, SEQ ID NO: 381, SEQ ID NO: 382, SEQ ID NO: 383, SEQ ID NO: 384, SEQ ID NO: 385, SEQ ID NO: 386, SEQ ID NO: 387, SEQ ID NO: 388, SEQ ID NO: 389, SEQ ID NO: 390, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 393, SEQ ID NO: 394, SEQ ID NO: 395, SEQ ID NO: 396, SEQ ID NO: 419, SEQ ID NO: 420, SEQ ID NO: 421, SEQ ID NO: 422, SEQ ID NO: 423, SEQ ID NO: 424, SEQ ID NO: 425, SEQ ID NO: 426, SEQ ID NO: 427, SEQ ID NO: 428, or SEQ ID NO: 429. 5. The composition of claim 1 further comprising at least one second polypeptide, wherein the second polypeptide is isolatable from a Staphylococcus aureus when incubated in culture media comprising an iron chelator, is not isolatable when grown in the culture media without the iron chelator, and comprises an amino acid sequence having at least 95% similarity to the amino acid sequence of any one of SEQ ID NO: 408, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 411, SEQ ID NO: 412, SEQ ID NO: 413, SEQ ID NO: 414, SEQ ID NO: 415, SEQ ID NO: 416, SEQ ID NO: 417, or SEQ ID NO: 418. 6. The composition of claim 5 wherein the second polypeptide comprises an amino acid sequence having at least 95% identity to the amino acid sequence of any one of SEQ ID NO: 408, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 411, SEQ ID NO: 412, SEQ ID NO: 413, SEQ ID NO: 414, SEQ ID NO: 415, SEQ ID NO: 416, SEQ ID NO: 417, or SEQ ID NO: 418. 7. The composition of claim 1 further comprising: an isolated polypeptide that is isolatable from a S. aureus when grown in culture media without an iron chelator and has a molecular weight of 150 kDa, 132 kDa, 120 kDa, 75 kDa, 58 kDa, 50 kDa, 44 kDa, 43 kDa, 41 kDa, 40 kDa; ora combination of said isolated polypeptides.
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이 특허에 인용된 특허 (35)
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Patti, Joseph M.; Foster, Timothy J.; Josefsson, Elisabet; Eidhin, Deidre Ni; Hook, Magnus A. O.; Perkins, Samuel E., Extracellular matrix-binding proteins from staphylococcus aureus.
Emery Daryll A. (Willmar MN) Straub Darren E. (Willmar MN) Huisinga Richard (Willmar MN), Method of priming an immune response in a one-day old animal.
Emery,Daryll A.; Straub,Darren E.; Zammert,Donavan E.; Kallevig,Gayla K., Methods for making compositions including gram negative microbial polypeptides.
Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
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