The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic e
The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.
대표청구항▼
1. A medical system comprising: a stent; anda drug eluting device comprising an expandable member coated with at least one layercomprising an adjustable matrix composition comprising a sol gel material and a bioactive material;wherein the expandable member has a plurality of expandable ribs that ext
1. A medical system comprising: a stent; anda drug eluting device comprising an expandable member coated with at least one layercomprising an adjustable matrix composition comprising a sol gel material and a bioactive material;wherein the expandable member has a plurality of expandable ribs that extend in a longitudinal direction to a flexible tip at one end and a sheath at a second end; andwherein the expandable member is made of a polymer of at least one of polyamide, polyolefin, polyethylene, polyester, polyurethane, elastomer, thermoplastic elastomer, nylon elastomer, nylon, nylon blends, copolyamide block ether, polyether block amides (PEBAX), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), latex, and silicone. 2. The medical system of claim 1, wherein said stent is a bare metal stent or a drug eluting stent. 3. The medical system of claim 1, further comprising a delivery catheter. 4. The medical system of claim 2, wherein said drug eluting stent contains the same bioactive material as that of said drug eluting device. 5. The medical system of claim 2, wherein said drug eluting stent contains a different bioactive material from that of said drug eluting device. 6. The medical system of claim 1, wherein the at least one coating is deposited in a gradient over a length of the drug eluting device. 7. The medical system of claim 1, wherein the bioactive material comprises at least one of an anti-restenotic agent, an anti-inflammatory agent, an HMG-CoA reductase inhibitor, an antimicrobial agent, an antineoplastic agent, an angiogenic agent, an anti-angiogenic agent, a thrombolytic agent, an antihypertensive agent, an anti-arrhythmic agent, a calcium channel blocker, a cholesterol-lowering agent, a psychoactive agent, an anti-depressive agent, an anti-seizure agent, a contraceptive, an analgesic, a bone growth factor, a bone remodeling factor, a neurotransmitter, a nucleic acid, an opiate antagonist; and combinations thereof. 8. The medical system of claim 1, wherein the bioactive material comprises paclitaxel, rampamycin, everolimus, tacrolimus, sirolimus, des-aspartate angiotensin, nitric oxide, apocynin, gamma-tocopheryl, pleiotrophin, estradiol, aspirin, statin, atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, and combinations thereof. 9. The medical system of claim 1, wherein the at least one coating is two or more coating layers, wherein each layer is different.
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