초록 ▼

Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed he

Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1A, 5-HT1B and 5-HT1D receptors without agonizing the 5-HT2B receptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT2B adrenergic alpha2A and/or the alpha2B receptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.

대표청구항 ▼

1. A compound of structural Formula (VII): or salts thereof, wherein:R1 is a C3-C6 cycloalkyl;R8 is independently selected from hydrogen or alkyl; orR1 and R8 along with the atoms to which they are attached form a 5, 6 or 7 membered ring;R3 independently selected from hydrogen or methyl;R4 and R5 ar

1. A compound of structural Formula (VII): or salts thereof, wherein:R1 is a C3-C6 cycloalkyl;R8 is independently selected from hydrogen or alkyl; orR1 and R8 along with the atoms to which they are attached form a 5, 6 or 7 membered ring;R3 independently selected from hydrogen or methyl;R4 and R5 are hydrogen; halo; or —OR120; orR4 and R5, together with the atoms to which they are joined form a double bond;R6 and R7 are independently selected from methyl, ethyl, CF3, or CH2CF3;R120 is independently selected from hydrogen or alkyl; andR9 is hydrogen. 2. The compound of claim 1, wherein R1 and R8, together with the atoms to which they are joined, form a 5 membered ring. 3. The compound of claim 1, wherein R8 is hydrogen. 4. The compound of claim 1, wherein R1 is cyclopropyl. 5. The compound of claim 4, wherein R6 and R7 are ethyl. 6. The compound of claim 4, wherein R6 and R7 are CF3. 7. The compound of claim 4, wherein R6 is ethyl and R7 is CF3. 8. The compound of claim 4, wherein R6 is ethyl and R7 is CH2CF3. 9. The compound of claim 1 having the following structural formula: 10. The compound of claim 1 having the following structural formula: 11. The compound of claim 1 having the following structural formula: 12. A composition comprising the compound of claim 1, 10, or 11 and a vehicle. 13. The compound of claim 1, wherein R1 is cyclopropyl and R4 and R5 are both hydrogen or form a double bond. 14. The compound of claim 1, wherein R6 is methyl, ethyl, CF3, or CH2CF3 and R7 is methyl or ethyl. 15. The compound of claim 4, wherein R6 and R7 are CH2CF3. 16. The compound of claim 5, 6, 7, 8 or 15, wherein R8 is hydrogen.