Methods of treating a fatty acid amide hydrolase-mediated condition
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-041/06
A61K-031/18
C07F-005/05
C07F-005/02
출원번호
US-0631712
(2015-02-25)
등록번호
US-9951089
(2018-04-24)
발명자
/ 주소
Austad, Brian C.
Grenier, Louis
Grogan, Michael J.
Liu, Tao
White, Priscilla L.
Martinot, Theodore A.
Yu, Lin-Chen
출원인 / 주소
Infinity Pharmaceuticals, Inc.
대리인 / 주소
TraskBritt
인용정보
피인용 횟수 :
0인용 특허 :
96
초록
The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
대표청구항▼
1. A method of treating an FAAH-mediated condition comprising administering to a subject in need thereof a therapeutically effective amount of a solid form of a crystalline compound of formula 1: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, or anhydride thereof, wherein the cr
1. A method of treating an FAAH-mediated condition comprising administering to a subject in need thereof a therapeutically effective amount of a solid form of a crystalline compound of formula 1: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, or anhydride thereof, wherein the crystalline compound of formula 1 is a Form A crystal form of formula 1 having an X-ray powder diffraction pattern comprising peaks at approximate peak positions of 17.26±0.10, 21.60±0.10, and 27.73±0.10 degrees 2θ and at least one peak at an approximate peak position of 9.68±0.10, 24.68±0.10, 25.48±0.10, and 29.08±0.10 degrees 2θ, wherein the FAAH-mediated condition is a painful condition. 2. The method according to claim 1, wherein the FAAH-mediated condition is a painful condition selected from the group consisting of inflammatory pain, joint pain, arthritic pain, lumbosacral pain, musculoskeletal pain, headache, migraine, muscle ache, lower back pain, neck pain, and toothache dental/maxillofacial pain. 3. The method according to claim 1, wherein the FAAH-mediated condition comprises diabetic neuropathy, sciatica, non-specific lower back pain, multiple sclerosis pain, fibromyalgia, HIV-related neuropathy, neuralgia, post-herpetic neuralgia, trigeminal neuralgia, or pain resulting from chronic inflammatory conditions. 4. The method according to claim 1, wherein the FAAH-mediated condition comprises post-herpetic neuralgia. 5. The method according to claim 1, wherein the FAAH-mediated condition comprises arthritic pain associated with crystalline arthritis, osteoarthritis, psoriatic arthritis, gouty arthritis, reactive arthritis, rheumatoid arthritis, or Reiter's arthritis. 6. The method according to claim 1, wherein the FAAH-mediated condition comprises joint pain. 7. The method according to claim 1, wherein the FAAH-mediated condition comprises arthritic pain.
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