Purified amniotic membrane compositions and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/50
A61K-009/00
A61K-031/738
C07K-014/47
C07K-014/81
A61K-038/17
A61K-035/48
A61K-038/39
A61K-038/48
C07K-014/78
A61K-009/06
A61K-009/08
A61L-015/44
출원번호
US-0848143
(2015-09-08)
등록번호
US-9956252
(2018-05-01)
발명자
/ 주소
Tseng, Scheffer
He, Hua
Li, Wei
출원인 / 주소
TISSUETECH, INC.
대리인 / 주소
Wilson Sonsini Goodrich & Rosati
인용정보
피인용 횟수 :
0인용 특허 :
104
초록▼
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtai
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
대표청구항▼
1. A composition comprising: (a) a water-soluble extract of amniotic membrane from frozen or previously frozen placenta, wherein the water-soluble extract comprises tumor necrosis factor-stimulated gene 6 (TSG-6), pentraxin (PTX-3), thrombospondin (TSP-1), and high molecular weight hyaluronan (HA) t
1. A composition comprising: (a) a water-soluble extract of amniotic membrane from frozen or previously frozen placenta, wherein the water-soluble extract comprises tumor necrosis factor-stimulated gene 6 (TSG-6), pentraxin (PTX-3), thrombospondin (TSP-1), and high molecular weight hyaluronan (HA) that is cross-linked by a covalent bond to a heavy chain of inter-a-trypsin inhibitor (IαI); (b) a thickening agent; and (c) glycerin. 2. The composition of claim 1, further comprising Smad7. 3. The composition of claim 1, wherein the amniotic membrane is human, bovine, or porcine. 4. The composition of claim 1, further comprising a pharmaceutically acceptable diluent, excipient, carrier, or combination thereof. 5. The composition of claim 1, wherein the thickening agent is selected from the group consisting of: xanthan gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, sodium carboxymethyl cellulose, and combinations thereof. 6. The composition of claim 1, wherein the composition is formulated as a non-solid dosage form. 7. The composition of claim 1, wherein the composition is formulated as a solution, drops, suspension, aerosol, paste, spray, ointment, oil, emulsion, cream, lotion, gel, a coated bandage, a patch, sticks, balms, or shampoo. 8. The composition of claim 1, wherein the composition is formulated for ophthalmic administration, systemic administration, or topical administration. 9. The composition of claim 1, wherein the composition is formulated for intraocular injection, subretinal injection, intravitreal injection, periocular injection, subconjuctival injection, retrobulbar injection, intracameral injection, sub-Tenon's injection, implantation, ocular implantation, ocular insertion, insertion between an eye and eyelid, or insertion in a conjunctival sac. 10. The composition of claim 1, wherein the composition further comprises a penetration enhancer and an aqueous adjuvant. 11. The composition of claim 1, wherein the composition is formulated as a solid dosage form. 12. The composition of claim 4, wherein the composition is formulated as a non-solid dosage form. 13. The composition of claim 4, wherein the composition is formulated as a solution, drops, suspension, aerosol, paste, spray, ointment, oil, emulsion, cream, lotion, gel, a coated bandage, a patch, sticks, balms, or shampoo. 14. The composition of claim 4, wherein the composition is formulated for ophthalmic administration, systemic administration, or topical administration. 15. The composition of claim 4, wherein the composition is formulated for intraocular injection, subretinal injection, intravitreal injection, periocular injection, subconjuctival injection, retrobulbar injection, intracameral injection, sub-Tenon's injection, implantation, ocular implantation, ocular insertion, insertion between an eye and eyelid, or insertion in a conjunctival sac. 16. The composition of claim 4, wherein the composition further comprises a penetration enhancer and an aqueous adjuvant. 17. The composition of claim 4, wherein the composition is formulated as a solid dosage form. 18. The composition of claim 4, wherein the composition is formulated as a solid oral dosage form. 19. The composition of claim 4, wherein the composition is formulated for controlled release. 20. A wound dressing comprising the composition of claim 1 and a backing material.
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