Method and apparatus for intra-aortic substance delivery to a branch vessel
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-025/00
A61M-025/04
A61B-017/12
A61M-025/06
A61M-025/10
출원번호
US-0033680
(2013-09-23)
등록번호
US-9956377
(2018-05-01)
발명자
/ 주소
Elkins, Jeffrey M.
Valencia, Aurelio
Patel, Samir R.
Aboytes, Ricardo
Goodson, Harry B.
Ball, Craig A.
출원인 / 주소
Elkins, Jeffrey M.
대리인 / 주소
Madonna, Esq., Zachary F.
인용정보
피인용 횟수 :
0인용 특허 :
237
초록▼
A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bilaterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having
A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bilaterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
대표청구항▼
1. A method of delivering fluid into the right and left renal arteries of a patient in conjunction with a radiographic contrast material administration procedure, comprising: administering a radiographic contrast material to the patient;placing a localized drug delivery system having a central longi
1. A method of delivering fluid into the right and left renal arteries of a patient in conjunction with a radiographic contrast material administration procedure, comprising: administering a radiographic contrast material to the patient;placing a localized drug delivery system having a central longitudinal axis within an abdominal aorta of the patient;maneuvering a first sub-catheter of the localized drug delivery system from the abdominal aorta into the right renal artery of the patient, a distal portion of the first sub-catheter having a memory shape that extends away from the central longitudinal axis of the localized drug delivery system;maneuvering a second sub-catheter of the localized drug delivery system from the abdominal aorta into the left renal artery of the patient, a distal portion of the second sub-catheter having a memory shape that extends away from the localized drug delivery system;delivering a first portion of the amount of fluid through the first sub-catheter and into the right renal artery; anddelivering a second portion of the amount of fluid through the second sub-catheter and into the left renal artery. 2. The method of claim 1, further comprising performing a coronary procedure on the patient while the localized drug delivery system is disposed within the abdominal aorta of the patient. 3. The method of claim 1, further comprising performing a coronary procedure on the patient while the first fluid portion and second fluid portion are passed into the right renal artery and left renal artery, respectively. 4. The method of claim 1, wherein the localized drug delivery system is inserted into the patient through a single percutaneous access. 5. The method of claim 4, wherein the single percutaneous access comprises a femoral artery access. 6. The method of claim 1, wherein the first portion and the second portion of the amount of fluid are passed into the right renal artery and left renal artery, respectively, simultaneously. 7. The method of claim 1, wherein the fluid comprises a vasodilator. 8. The method of claim 7, wherein the vasodilator comprises a member selected from the group consisting of papavarine, fenoldopam mesylate, a calcium-channel blocker, atrial natriuretic peptide (ANP), acetylcholine, nifedipine, nitroglycerine, nitroprusside, adenosine, dopamine, and theophylline. 9. The method of claim 1, wherein the fluid comprises an antioxidant. 10. The method of claim 9, wherein the antioxidant comprises acetylcysteine. 11. The method of claim 1, wherein the fluid comprises a diuretic. 12. The method of claim 11, wherein the diuretic comprises a member selected from the group consisting of mannitol and furosemide. 13. The method of claim 1, wherein the patient exhibits a rise in serum creatinine of more than 25% or an absolute rise in serum creatinine of 0.5 mg/dl within 48 hours. 14. A method of delivering fluid into the right and left renal arteries of a patient in conjunction with a surgical intervention, comprising: performing the surgical intervention on the patient;placing a localized drug delivery system having a central longitudinal axis within an abdominal aorta of the patient;maneuvering a first sub-catheter of the localized drug delivery system from the abdominal aorta into the right renal artery of the patient, a distal portion of the first sub-catheter having a memory shape that extends away from the central longitudinal axis of the localized drug delivery system;maneuvering a second sub-catheter of the localized drug delivery system from the abdominal aorta into the left renal artery of the patient, a distal portion of the second sub-catheter having a memory shape that extends away from the central longitudinal axis of the localized drug delivery system;delivering an amount of fluid through the localized drug delivery system;passing a first portion of the amount of fluid through the first sub-catheter and into the right renal artery; andpassing a second portion of the amount of fluid through the second sub-catheter and into the left renal artery. 15. The method of claim 14, wherein the surgical intervention comprises a cardiac interventional procedure. 16. The method of claim 14, wherein the surgical intervention comprises a member selected from the group consisting of an angioplasty, a coronary artery bypass, a valve repair, and a valve replacement. 17. A method of delivering fluid into the right and left renal arteries of a patient, comprising: placing at localized drug delivery system having a central longitudinal axis within an abdominal aorta of the patient, the localized drug delivery system comprising a first sub-catheter in fluid communication with a second sub-catheter;maneuvering the first sub-catheter of the localized drug delivery system from the abdominal aorta, through a right renal ostia, and into the right renal artery of the patient, a distal portion of the first sub-catheter having a memory shape that extends away from the central longitudinal axis of the localized drug delivery system;maneuvering the second sub-catheter of the localized drug delivery system from the abdominal aorta, through a left renal ostia, and into the left renal artery of the patient, a distal portion of the second sub-catheter having a memory shape that extends away from the central longitudinal axis of the localized drug delivery system;delivering an amount of fluid through the localized drug delivery system while allowing an amount of blood to flow through the abdominal aorta of the patient from a location upstream of right and left renal ostia that are located at unique positions along the abdominal aorta to a location downstream of the right and left renal ostia;passing a first portion of the amount of fluid through the first sub-catheter and into the right renal artery; andpassing a second portion of the amount of fluid through the second sub-catheter and into the left renal artery. 18. The method of claim 17, further comprising performing a coronary procedure on the patient while the localized drug delivery system is disposed within the abdominal aorta of the patient. 19. The method of claim 17, further comprising performing a coronary procedure on the patient while the first fluid portion and the second fluid portion are passed into the right renal artery and left renal artery, respectively. 20. The method of claim 17, wherein the localized drug delivery system is inserted into the patient through a single percutaneous access.
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이 특허에 인용된 특허 (237)
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