최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0154781 (2014-01-14) |
등록번호 | US-9963288 (2018-05-08) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 1 인용 특허 : 329 |
A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the stor
A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
1. An apparatus comprising: a body;a sterile chamber within the body hermetically sealed from the ambient atmosphere;anda valve coupled in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (
1. An apparatus comprising: a body;a sterile chamber within the body hermetically sealed from the ambient atmosphere;anda valve coupled in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the valve, to one or more of pass substance therethrough from the chamber, or pass substance therethrough to the chamber,wherein the valve includes a valve member movable between the closed and open positions and defining at least one exposed surface exposed to ambient atmosphere in the closed position;wherein the valve is configured for engagement with a probe or filling or evacuation member to move the valve member between the closed and open positions so that, when the valve is in the open position, substance passes through the valve without contacting the at least one exposed surface; andwherein the apparatus is configured to maintain sterility of a sterile substance entering the apparatus and passing through the valve in the open position to the chamber, thereby permitting aseptic passage of sterile substance into the chamber. 2. An apparatus as defined in claim 1, wherein the valve includes a spring that biases or urges the valve toward the closed position. 3. An apparatus as defined in claim 2, wherein the spring is formed integral with the valve. 4. An apparatus as defined in claim 3, wherein the spring is approximately dome-shaped. 5. An apparatus as defined in claim 1, wherein the spring applies both radially directed and axially directed forces to the valve to bias or urge the valve toward the closed position. 6. An apparatus as defined in claim 1, wherein at least one flow aperture is formed through the spring and is coupled in fluid communication between the valve and the chamber. 7. An apparatus as defined in claim 1, further comprising a spring coupled to the valve member and biasing the valve member toward the closed position. 8. An apparatus as defined in claim 7, wherein the spring is formed integral with the valve member. 9. An apparatus as defined in claim 8, wherein the spring defines an annular, curvilinear wall extending axially and radially from the valve member. 10. An apparatus as defined in claim 9, wherein the annular, curvilinear wall of the spring is approximately dome shaped. 11. An apparatus as defined in claim 1, wherein the valve further includes a valve seat engagable with the valve member in the closed position to form a fluid-tight seal therebetween. 12. An apparatus as defined in claim 1, wherein the valve includes a valve seat and a sealing surface movable relative to the valve seat between closed and open positions, wherein the sealing surface is engagable with the valve seat in the closed position to form a fluid-tight seal therebetween, and is spaced away from the valve seat in the open position to form a valve opening for the passage of substance therethrough. 13. An apparatus as defined in claim 1, further comprising a tube coupled in fluid communication with the valve. 14. An apparatus as defined in claim 1, further including a nozzle in fluid communication with the chamber. 15. An apparatus as defined in claim 1, further comprising a probe engagable with the valve to thereby open the valve and at least one of pass substance therethrough from the chamber, and pass substance therethrough to the chamber. 16. An apparatus as defined in claim 15, wherein the probe defines a passageway therethrough and an opening at an end thereof in fluid communication with the passageway configured for passing substance through the valve. 17. An apparatus as defined in claim 15, further comprising a substance source coupled in fluid communication with the probe for passing substance therethrough. 18. An apparatus as defined in claim 17, wherein the substance source comprises one or more of medicament, a cosmetic, food product, sterile substance or preservative free substance. 19. A method comprising: passing a sterile substance into or out of a device comprising a body, a sterile chamber within the body hermetically sealed from the ambient atmosphere, a valve coupled in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the valve to one or more of pass substance therethrough from the chamber or pass substance therethrough to the chamber, wherein the valve (i) includes a valve member movable between the closed and open positions and defines at least one exposed surface exposed to ambient atmosphere in the closed position; and (ii) is configured for engagement with a probe or filling or evacuation member to move the valve member between the closed and open positions so that, when the valve is in the open position, substance passes through the valve without contacting the at least one exposed surface;said passing step including: moving the valve member from the closed position to the open position;passing the sterile substance through the valve and into or out of the chamber without contacting the at least one exposed surface;and maintaining the sterility of the sterile substance during the passing step. 20. A method as defined in claim 19, further comprising biasing the valve toward the closed position. 21. A method as defined in claim 20, wherein said biasing step includes biasing the valve toward the closed position with a spring having at least one flow aperture therethrough coupled in fluid communication between the valve and the chamber, and said step of passing substance through the valve includes passing substance through the at least one flow aperture. 22. A method as defined in claim 19, wherein the valve includes a valve seat and the valve member engagable with the valve seat to define the closed position and movable between the closed and the open position in which the valve member is spaced away from the valve seat, and said moving step includes moving the valve member from the closed position to the open position. 23. A method as defined in claim 19, further comprising passing substance out of the chamber through a nozzle of the device. 24. A method as defined in claim 19, further comprising engaging the valve with a probe, wherein said moving step includes moving the valve from the closed position to the open position with an end of the probe. 25. A method as defined in claim 24, further comprising introducing substance to the chamber from a substance source coupled in fluid communication with the probe. 26. An apparatus comprising: a body;a sterile chamber within the body hermetically sealed from the ambient atmosphere;a first valve coupleable in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the first valve to one or more of pass substance therethrough from the chamber or pass substance therethrough to the chamber; anda second valve coupleable in fluid communication with one or more of the first valve or the chamber and defining (1) a normally closed, fluid-tight position preventing the passage of substance therethrough, and (2) an open position for passing substance therethrough;wherein the apparatus is configured to maintain sterility of a sterile substance entering the apparatus and passing through the first valve in the open position to the chamber, thereby permitting aseptic passage of sterile substance into the chamber. 27. An apparatus as defined in claim 26, further including a spring that biases the first valve toward the closed position. 28. An apparatus as defined in claim 27, wherein the spring is integral with the first valve. 29. An apparatus as defined in claim 27, wherein the spring is approximately dome-shaped. 30. An apparatus as defined in claim 26, wherein the first valve includes a valve member movable between the closed and open positions and the valve member is biased toward the closed position. 31. An apparatus as defined in claim 30, wherein the first valve further includes a valve seat engageable with the valve member in the closed position to form a fluid-tight seal therebetween. 32. An apparatus as defined in claim 27, wherein the spring includes at least one flow aperture therethrough coupled in fluid communication between the first valve and the chamber. 33. An apparatus as defined in claim 26, wherein the first valve includes at least one valve seat and at least one sealing surface movable relative to the at least one valve seat between closed and open positions, wherein in the closed position the at least one sealing surface engages the at least one valve seat to form a fluid-tight seal therebetween, and in the open position the at least one sealing surface is spaced away from the at least one valve seat to form a valve opening for the passage of substance therethrough. 34. An apparatus as defined in claim 26, wherein the second valve includes a valve member movable between the closed and open positions and the valve member is biased toward the closed position. 35. An apparatus as defined in claim 26, further comprising a tube coupled in fluid communication with the first valve. 36. An apparatus as defined in claim 35, further comprising a substance source coupled in fluid communication with the tube for introducing substance therethrough and into the chamber. 37. An apparatus as defined in claim 36, wherein the substance source comprises one or more of medicament, a cosmetic, food product, sterile substance or preservative free substance. 38. A method comprising: passing a sterile substance into and out of a device comprising a body, a sterile chamber within the body hermetically sealed from the ambient atmosphere, a first valve coupleable in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the first valve to one or more of pass substance therethrough from the chamber or pass substance therethrough to the chamber, and a second valve coupleable in fluid communication with one or more of the first valve or the chamber and defining (1) a normally closed, fluid-tight position preventing the passage of substance therethrough, and (2) an open position for passing substance therethrough, said passing step including: moving the first valve from the closed position to the open position;moving the second valve from the closed position to the open position;passing the sterile substance through the first valve;passing the sterile substance through the second valve; andmaintaining sterility of the sterile substance entering the device during said passing steps. 39. A method as defined in claim 38, further including biasing one or more of the first valve or the second valve toward the respective closed position thereof. 40. A method as defined in claim 39, wherein said biasing step includes biasing the first valve toward the closed position with a spring having at least one flow aperture therethrough coupled in fluid communication between the first valve and the chamber, and said step of passing substance through the first valve includes passing substance through the at least one flow aperture. 41. A method as defined in claim 38, wherein the first valve includes a valve seat and a valve member engagable with the valve seat to define the closed position and movable between the closed and the open position in which the valve member is spaced away from the valve seat, and said step of moving the first valve from the closed position to the open position includes moving the valve member from the closed position to the open position. 42. A method as defined in claim 38, further comprising introducing substance to the device from a substance source coupled in fluid communication therewith. 43. An apparatus comprising: a body;a sterile chamber within the body hermetically sealed from the ambient atmosphere;a valve coupled in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the valve to one or more of pass substance therethrough from the chamber or pass substance therethrough to the chamber, anda spring formed integral with the valve that biases or urges the valve toward the closed position, wherein the spring one or more of (i) is approximately dome-shaped or (ii) defines an annular, curvilinear wall extending axially and radially from the valve member. 44. An apparatus comprising: a body;a sterile chamber within the body hermetically sealed from the ambient atmosphere;a first valve coupleable in fluid communication with the chamber and defining (1) a normally closed, fluid-tight position hermetically sealing the chamber from the ambient atmosphere, and (2) an open position allowing the passage of substance through the first valve to one or more of pass substance therethrough from the chamber or pass substance therethrough to the chamber;a spring formed integral with the first valve that biases or urges the first valve toward the closed position, wherein the spring one or more of (i) is approximately dome-shaped or (ii) defines an annular, curvilinear wall extending axially and radially from the valve member; anda second valve coupleable in fluid communication with one or more of the first valve or the chamber and defining (1) a normally closed, fluid-tight position preventing the passage of substance therethrough, and (2) an open position for passing substance therethrough. 45. An apparatus as defined in claim 1, further comprising a probe or filling or evacuation member configured to engage the at least one exposed surface, move the valve member between the closed and open positions, and pass substance through the valve without contacting the at least one exposed surface. 46. A method as defined in claim 19, further comprising engaging a probe or filling or evacuation member with the at least one exposed surface, moving the valve member between the closed and open positions, and passing substance through the valve without contacting the at least one exposed surface.
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