A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by th
A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.
대표청구항▼
1. A convection enhanced delivery device comprising: (a) a flexible support member free of any structure for mounting the support member on a bone, the support member including a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surf
1. A convection enhanced delivery device comprising: (a) a flexible support member free of any structure for mounting the support member on a bone, the support member including a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone;(b) an elongated first microcatheter carried by the support member, the first microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the first microcatheter is disposed adjacent the support member and an opposite distal end of the first microcatheter is spaced apart from the support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter;(c) a first fluid conduit carried by the support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen;(d) an inlet port carried by the support member, the inlet port being in fluid communication with the first fluid conduit; and(e) a connecting port carried by the support member and separate from the inlet port, the connecting port being in fluid communication with the first fluid conduit, the connecting port being configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member. 2. A convection enhanced delivery device according to claim 1 wherein the connecting port is disposed at an external surface of the support member, the connecting port being presented in a third direction different than the first direction. 3. A convection enhanced delivery device according to claim 1 wherein the first fluid conduit is embedded in the support member. 4. A convection enhanced delivery device according to claim 1 wherein the first fluid conduit is formed in the support member. 5. A convection enhanced delivery device according to claim 1 further comprising a second fluid conduit carried by the support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a third direction different than the first direction and the second direction, the second conduit lumen being in fluid communication with the first conduit lumen. 6. A convection enhanced delivery device according to claim 1 further comprising (f) an elongated second microcatheter carried by the support member, the second microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the second microcatheter is disposed adjacent the support member and an opposite distal end of the second microcatheter is spaced apart from the support member, the second microcatheter including a second catheter lumen extending in a third direction lengthwise of the second microcatheter; and(g) a second fluid conduit carried by the support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a fourth direction different than the first direction and the second direction, the second conduit lumen being in fluid communication with the second catheter lumen. 7. A convection enhanced delivery device according to claim 6 wherein the first conduit lumen is in fluid communication with the second conduit lumen. 8. A kit of components for a convection enhanced delivery system comprising at least two convection enhanced delivery devices and at least one external fluid conduit for interconnecting said at least two convection enhanced delivery devices, each convection enhanced delivery device comprising: (a) a flexible support member free of any structure for mounting the support member on a bone, the support member including a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone;(b) an elongated microcatheter carried by the support member, the microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the microcatheter is disposed adjacent the support member and an opposite distal end of the microcatheter is spaced apart from the support member, the microcatheter including a catheter lumen extending in a first direction lengthwise of the microcatheter;(c) a first fluid conduit carried by the support member, the first fluid conduit including a conduit lumen, the conduit lumen extending in a second direction different than the first direction, the conduit lumen being in fluid communication with the catheter lumen;(d) an inlet port carried by the support member, the inlet port being in fluid communication with the first fluid conduit; and(e) a connecting port carried by the support member and separate from the inlet port, the connecting port being in fluid communication with the first fluid conduit, the connecting port being configured to engage an end portion of the at least one external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member. 9. A kit of components for a convection enhanced delivery system according to claim 8 further comprising a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support the support member of at least one of the convection enhanced delivery devices while permitting the microcatheter carried by the support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 10. A convection enhanced delivery system comprising: (a) an external fluid conduit;(b) a first convection enhanced delivery device comprising (i) a flexible first support member free of any structure for mounting the first support member on a bone, the first support member including a first tissue contacting surface, the first tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone,(ii) an elongated first microcatheter carried by the first support member, the first microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the first microcatheter is disposed adjacent the first support member and an opposite distal end of the first microcatheter is spaced apart from the first support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter,(iii) a first fluid conduit carried by the first support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen,(iv) a first inlet port carried by the first support member, the first inlet port being in fluid communication with the first fluid conduit, and(v) a first connecting port carried by the first support member and separate from the first inlet port, the first connecting port being in fluid communication with the first fluid conduit, the first connecting port being configured to engage a first end portion of the external fluid conduit such that the external fluid conduit projects away from the first connecting port and from the first support member; and(c) a second convection enhanced delivery device comprising (i) a second support member free of any structure for mounting the second support member on a bone,(ii) an elongated second microcatheter carried by the second support member, the second microcatheter having a length and projecting lengthwise away from the second support member such that a proximal end of the second microcatheter is disposed adjacent the second support member and an opposite distal end of the second microcatheter is spaced apart from the second support member, the second microcatheter including a second catheter lumen extending in a third direction lengthwise of the second microcatheter,(iii) a second fluid conduit carried by the second support member, the second fluid conduit including a second conduit lumen, the second conduit lumen extending in a fourth direction different than the third direction, the second conduit lumen being in fluid communication with the second catheter lumen,(iv) a second inlet port carried by the second support member, the second inlet port being in fluid communication with the second fluid conduit, and(v) a second connecting port carried by the second support member and separate from the second inlet port, the second connecting port being in fluid communication with the second fluid conduit, the second connecting port engaging a second end portion of the external fluid conduit such that the external fluid conduit projects away from the second connecting port and from the second support member. 11. A convection enhanced delivery system according to claim 10, wherein the first convection enhanced delivery device further comprises (vi) an elongated third microcatheter carried by the first support member, the third microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the third microcatheter is disposed adjacent the first support member and an opposite distal end of the third microcatheter is spaced apart from the first support member, the third microcatheter including a third catheter lumen extending in a fifth direction lengthwise of the third microcatheter; and(vii) a third fluid conduit carried by the first support member, the third fluid conduit including a third conduit lumen, the third conduit lumen extending in a sixth direction different than the first direction and the second direction, the third conduit lumen being in fluid communication with the third catheter lumen. 12. A convection enhanced delivery device according to claim 11 wherein the first conduit lumen is in fluid communication with the third conduit lumen. 13. A convection enhanced delivery system according to claim 10 further comprising a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support at least one of the first and second support members while permitting at least one of the first microcatheter and the second microcatheter carried by said at least one of the first and second support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 14. A convection enhanced delivery system according to claim 13, wherein at least one of the first and second convection enhanced delivery devices also comprises an attachment mechanism configured to attach said at least one of the first and second convection enhanced delivery devices to the mesh support structure, the attachment mechanism including at least one leg configured and dimensioned to directly engage at least one cross member of the mesh support structure. 15. A convection enhanced delivery system according to claim 10 wherein the second support member is flexible and includes a second tissue contacting surface, the second tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone. 16. A convection enhanced delivery system comprising: (a) a first convection enhanced delivery device comprising (i) a flexible first support member, the first support member including a first tissue contacting surface, the first tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone,(ii) an elongated first microcatheter carried by the first support member, the first microcatheter having a length and projecting lengthwise away from the first support member such that a proximal end of the first microcatheter is disposed adjacent the first support member and an opposite distal end of the first microcatheter is spaced apart from the first support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter, and(iii) a first inlet port carried by the first support member, the first inlet port being in fluid communication with the first microcatheter; and(b) a mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support the first support member of the first convection enhanced delivery device while permitting the first microcatheter carried by the first support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 17. A convection enhanced delivery system according to claim 16, wherein the first convection enhanced delivery device further comprises: (iv) a first fluid conduit carried by the first support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen, and(v) a first connecting port carried by the first support member and separate from the first inlet port, the first connecting port being in fluid communication with the first fluid conduit, the first connecting port being configured to engage a first end portion of an external fluid conduit such that the external fluid conduit projects away from the first connecting port and from the first support member. 18. A convection enhanced delivery system according to claim 16, wherein the first convection enhanced delivery device also comprises an attachment mechanism configured to attach the first convection enhanced delivery device to the mesh support structure, the attachment mechanism including at least one leg configured and dimensioned to directly engage at least one cross member of the mesh support structure. 19. A convection enhanced delivery system according to claim 16, further comprising: (c) a second convection enhanced delivery device comprising (i) a second support member,(ii) an elongated second microcatheter carried by the second support member, the second microcatheter having a length and projecting lengthwise away from the second support member such that a proximal end of the second microcatheter is disposed adjacent the second support member and an opposite distal end of the second microcatheter is spaced apart from the second support member, the second microcatheter including a second catheter lumen extending in a second direction lengthwise of the second microcatheter, and(iii) a second inlet port carried by the second support member, the second inlet port being in fluid communication with the second microcatheter, the mesh support structure being configured and dimensioned to support the second support member of the second convection enhanced delivery device while permitting the second microcatheter carried by the second support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 20. A convection enhanced delivery system according to claim 19 wherein the second support member is flexible and includes a second tissue contacting surface, the second tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone. 21. A method of implanting a convection enhanced delivery device in brain tissue located within a cranial cavity defined by a skull, the convection enhanced delivery device comprising: (i) a flexible support member free of any structure for mounting the support member on the skull, the support member including a tissue contacting surface, the tissue contacting surface being configured to be positioned in substantially complete surface contact with tissue other than bone;(ii) an elongated first microcatheter carried by the support member, the first microcatheter having a length and projecting lengthwise away from the support member such that a proximal end of the first microcatheter is disposed adjacent the support member and an opposite distal end of the first microcatheter is spaced apart from the support member, the first microcatheter including a first catheter lumen extending in a first direction lengthwise of the first microcatheter;(iii) a first fluid conduit carried by the support member, the first fluid conduit including a first conduit lumen, the first conduit lumen extending in a second direction different than the first direction, the first conduit lumen being in fluid communication with the first catheter lumen;(iv) an inlet port carried by the support member, the inlet port being in fluid communication with the first fluid conduit; and(v) a connecting port carried by the support member and separate from the inlet port, the connecting port being in fluid communication with the first fluid conduit, the connecting port being configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member,the method comprising the steps of:(a) providing an opening in the skull;(b) inserting the convection enhanced delivery device through the opening into the cranial cavity defined by the skull; and(c) placing the support member proximate the brain tissue so that the first microcatheter is inserted into the brain tissue. 22. A method according to claim 21 wherein the step of placing the support member proximate the brain tissue includes positioning the tissue contacting surface in substantially complete surface contact with the brain tissue. 23. A method according to claim 21 further comprising the steps of: (d) inserting a mesh support structure through the opening into the cranial cavity defined by the skull;(e) placing the mesh support structure proximate the brain tissue; and(f) attaching the convection enhanced delivery device to the mesh support structure, the mesh support structure including cross members extending in transverse directions to one another so as to define openings through the mesh support structure, the mesh support structure being configured and dimensioned to support the support member of the convection enhanced delivery device while permitting the microcatheter carried by the support member to extend through at least one of the openings defined in the mesh support structure by the cross members. 24. A method according to claim 23 wherein the convection enhanced delivery device also comprises an attachment mechanism configured to attach the convection enhanced delivery device to the mesh support structure, the attachment mechanism including at least one leg configured and dimensioned to directly engage at least one cross member of the mesh support structure.
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Markulec Jeffrey R. ; Rex Dennis G. ; Schuster Richard E. ; Elliot Brent D., Building blocks for integrated gas panel.
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