[특허]Cancer vaccine compositions and methods of using the same

Cancer vaccine compositions and methods of using the same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-039/00 A61P-037/04 A61P-035/00 A61K-009/00 A61K-009/107 A61K-031/00 A61K-031/7088 A61K-039/39 A61P-035/04
출원번호	US-0129795 (2009-11-17)
등록번호	US-9974844 (2018-05-22)
국제출원번호	PCT/US2009/064822 (2009-11-17)
§371/§102 date	20110729 (20110729)
국제공개번호	WO2010/057197 (2010-05-20)
발명자 / 주소	Myc, Andrzej Kryczek, Ilona Baker, Jr., James R.
출원인 / 주소	THE REGENTS OF THE UNIVERSITY OF MICHIGAN
대리인 / 주소	Casimir Jones S.C.
인용정보	피인용 횟수 : 0 인용 특허 : 85

초록 ▼

The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

대표청구항 ▼

1. An immunogenic composition for stimulating a cancer specific immune response comprising: a) a nanoemulsion, wherein the nanoemulsion comprises oil, water, an organic solvent, a non-ionic surfactant, and a cationic surfactant; andb) a cancer immunogen comprising cancer cells that have undergone membrane disruption. 2. The immunogenic composition of claim 1, wherein said cancer cells that have undergone membrane disruption are selected from the group consisting of cancer cells that have undergone freeze-thaw lysis and cancer cells that have been exposed to UV radiation. 3. The immunogenic composition of claim 1, wherein the nanoemulsion comprises an organic solvent selected from ethanol, glycerol or a combination thereof; a cationic surfactant selected from cetylpyridinium chloride (CPC), benzalkonium chloride or a combination thereof; and a non-ionic surfactant selected from Poloxamer 407, polysorbate 80, or polysorbate 20. 4. The immunogenic composition of claim 1, wherein the nanoemulsion comprises: a) about 10% to about 80% oil;b) about 1% to about 50% organic solvent;c) about 0.1% to about 10% non-ionic surfactant; andd) about 0.01% to about 3% cationic surfactant. 5. The immunogenic composition of claim 1, wherein the nanoemulsion comprises: a) water;b) ethanol;c) cetylpyridinium chloride;d) polysorbate 80 or polysorbate 20; ande) soybean oil. 6. The immunogenic composition of claim 1, wherein the nanoemulsion further comprises a chelating agent. 7. The immunogenic composition of claim 6, wherein the nanoemulsion comprises about 0.0005% to about 1.0% of the chelating agent. 8. The immunogenic composition of claim 6, wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA). 9. A method of using the immunogenic composition of claim 1 to induce a cancer-specific immune response in a subject comprising mucosally administering an effective amount of the immunogenic composition to the subject to produce a cancer specific immune response. 10. The method of claim 9, wherein the immunogenic composition is administered to the subject after surgical removal of cancer in the subject.

이 특허에 인용된 특허 (85)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Cancer vaccine compositions and methods of using the same 원문보기

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Cancer vaccine compositions and methods of using the same 원문보기

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