Periodontal regeneration composition and method of using same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-045/06
A61K-033/42
A61K-033/06
A61K-038/39
A61L-027/24
A61L-027/26
A61L-027/36
A61L-027/44
A61L-027/46
A61L-027/50
A61L-027/52
A61L-027/54
출원번호
US-0655969
(2012-10-19)
등록번호
US-10004806
(2018-06-26)
발명자
/ 주소
Szymaitis, Dennis W.
출원인 / 주소
Periovance, Inc.
대리인 / 주소
Pepper Hamilton LLP
인용정보
피인용 횟수 :
0인용 특허 :
33
초록▼
A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket thro
A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket through an 18 gauge needle. The composition may contain a thickener that increases the viscosity of the composition after the material has been injected into the periodontal pocket. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a time of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.
대표청구항▼
1. A bone growth and adjacent tissue regeneration composition for treatment of bone loss comprising a mixture of particles of a bone growth material, free collagen, a thickener and a fluid wherein the thickener is a physiological compatible compound that slowly forms an insoluble salt with at least
1. A bone growth and adjacent tissue regeneration composition for treatment of bone loss comprising a mixture of particles of a bone growth material, free collagen, a thickener and a fluid wherein the thickener is a physiological compatible compound that slowly forms an insoluble salt with at least one component in the mixture. 2. The composition of claim 1 wherein the thickener is a physiologically compatible compound which is liquid above a physiological temperature. 3. The composition of claim 2 wherein the compound is an oligosaccharide. 4. The composition of claim 3 wherein the oligosaccharide is a polyethylene glycol. 5. The composition of claim 1 wherein the thickener is a material that is activated by at least one of air, heat, light and a catalyst. 6. The composition of claim 1 wherein the thickener is a material that absorbs water. 7. The composition of claim 1 further comprising an adhesive placed over a portion of the mixture, the adhesive being selected from the group comprising water curable adhesives, visible light curable adhesives, auto curing adhesives, heat curable adhesives, reactive-component cure adhesives, surface activated adhesives, and curable adhesives that cure when exposed to ultraviolet radiation. 8. The composition of claim 1 further comprising wherein the mixture is subjected to infusion of energy from at least one energy source sufficient to dissociate the collagen fiber without denaturing proteins in the collagen fibers and to allow at least some of the particles of bone growth material to be captured between adjacent collagen fibers after the infusion of energy has ceased. 9. The composition of claim 8 in which the energy source is selected from the group consisting of a water bath, an oil bath, a microwave source, a radiant heat source, and a sonicator. 10. The composition of claim 7 further comprising wherein an infusion of energy is provided by heating the composition in one of an oven, a water bath, and an oil bath. 11. The composition of claim 1 further comprising wherein the composition is heated to a temperature at least 110° F. for a time period sufficient to cause the collagen fiber in the composition to melt but not to degrade. 12. The composition of claim 11 wherein the heat is provided by a water bath between 110° F. and 180° F. 13. The composition of claim 11 wherein the heat is provided by a water bath between 120° F. and 160° F. for less than 20 minutes. 14. The composition of claim 1 further comprising at least one material selected from the group consisting of growth factors, nutrient factors, drugs, calcium containing compounds, anti-inflammatory agents, anti-microbial agents, root treatment materials, bone morphogenic proteins, dental matrix derivatives, and combinations thereof. 15. The composition of claim 1 further comprising wherein the bone growth material is a material selected from the group consisting of human bone particles, hydroxyapatite, animal bone particles, ground coral, calcium sulfate, calcium carbonate, substituted and unsubstituted calcium phosphate cements, bioactive glasses, polymers that promote bone growth and combinations thereof. 16. The composition of claim 1 further comprising at least one matrix forming material selected from the group consisting of cross-linked collagen, water soluble polymers, gelling polymers, hydrocolloids, hydrogels, polyethyleneglycols, natural polymers, chemically modified natural polymers, synthetic polymers and copolymers, colloids, thermosetting polymers and thermoplastic polymers. 17. The composition of claim 16 wherein at least one of the matrix-forming materials gets more viscous at or below 98.6° F. 18. The composition of claim 16 wherein at least one of the matrix-forming materials melts at or above 98.6° F. 19. The composition of claim 1 further comprising wherein the composition, after formulation, is stored in one selected from the group consisting of a refrigerator at a temperature above 32° F. and a freezer at a temperature below 32° F. 20. The composition of claim 1 wherein the fluid is a biocompatible fluid selected from the group consisting of normal saline, water, and inorganic salt solutions. 21. The composition of claim 1 wherein up to 10% of the total fluid volume is comprised of a biocompatible and water-miscible organic solvent.
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