[특허]Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith

Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/50 A61K-009/00 A61K-031/56 A61K-031/58
출원번호	US-0222082 (2014-03-21)
등록번호	US-9987233 (2018-06-05)
발명자 / 주소	Helliwell, James A. Malone, Amanda M. Smith, Thomas J. Baum, Marc M.
출원인 / 주소	Eupraxia Pharmaceuticals USA LLC
대리인 / 주소	Seed IP Law Group LLP
인용정보	피인용 횟수 : 0 인용 특허 : 103

초록

Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

대표청구항 ▼

1. A pharmaceutical composition, comprising: a plurality of microparticles, each microparticle including: (1) a crystalline drug core of more than 70% by weight of the microparticle, each crystalline drug core comprising 100% of fluticasone propionate; and(2) a polymeric shell encapsulating the crystalline drug core, the polymeric shell being in contact but immiscible with the crystalline drug core, and the polymeric shell comprising polyvinyl alcohol (PVA), wherein the polymeric shell is heat treated within a temperature range of 210-230° C. for at least one hour,wherein, when dissolution tested using United States Pharmacopoeia Type II apparatus, said microparticles release dissolved fluticasone or a pharmaceutically acceptable salt or ester thereof at a dissolution half-life of 12-20 hours, wherein the dissolution conditions are: 3 milligrams of microparticles in 200 milliliters of dissolution medium of 70% v/v methanol and 30% v/v of water at 25° C.,and wherein the plurality of microparticles have a mean diameter in the range of 80 μm to 150 μm and a standard deviation of less than 50% of the mean diameter. 2. The pharmaceutical composition of claim 1 wherein the plurality of microparticles have a mean diameter of 80 μm and a standard deviation of less than 50% of the mean diameter. 3. The pharmaceutical composition of claim 1 wherein the plurality of microparticles have a mean diameter of 150 μm and a standard deviation of less than 50% of the mean diameter. 4. The pharmaceutical composition of claim 1 wherein each microparticle comprises 90-98% w/w of crystalline drug core and 2-10% w/w of polymeric shell. 5. A pharmaceutical composition, comprising: a plurality of microparticles, each microparticle including: (1) a crystalline drug core of more than 70% by weight of each microparticle, the crystalline drug core comprising 100% of fluticasone propionate; and(2) a polymeric shell encapsulating the crystalline drug core, the polymeric shell being in contact but immiscible with the crystalline drug core, and the polymeric shell comprising polyvinyl alcohol (PVA), wherein the polymeric shell is heat treated within a temperature range of 210-230 C for at least one hour,wherein, when dissolution tested using United States Pharmacopoeia Type II apparatus, said microparticles release dissolved fluticasone or a pharmaceutically acceptable salt or ester thereof at a dissolution half-life of 12-20 hours, wherein the dissolution conditions are: 3 milligrams of microparticles in 200 milliliters of dissolution medium of 70% v/v methanol and 30% v/v of water at 25° C., andwherein the microparticles have a mean diameter in the range of 50-100 μm. 6. The pharmaceutical composition of claim 5 wherein each microparticle comprises 90-98% w/w of crystalline drug core and 2-10% w/w of polymeric shell. 7. A pharmaceutical composition, comprising: a plurality of microparticles, each microparticle including: (1) a crystalline drug core of more than 70% by weight of each microparticle, the crystalline drug core comprising 100% of fluticasone propionate; and(2) a polymeric shell encapsulating the crystalline drug core, the polymeric shell being in contact but immiscible with the crystalline drug core and the polymeric shell comprising polyvinyl alcohol (PVA),wherein, when dissolution tested using United States Pharmacopoeia Type II apparatus, said microparticles release dissolved fluticasone or a pharmaceutically acceptable salt or ester thereof at a dissolution half-life of 12-20 hours, wherein the dissolution conditions are: 3 milligrams of microparticles in 200 milliliters of dissolution medium of 70% v/v methanol and 30% v/v of water at 25° C.,wherein more than 90% of the microparticles have diameters in the range of 50-100 μm, and wherein the polymeric shell is heat treated within a temperature range of 210-230° C. for at least one hour. 8. The pharmaceutical composition of claim 7 wherein each microparticle comprises 90-98% w/w of crystalline drug core and 2-10% w/w of polymeric shell.

이 특허에 인용된 특허 (103)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
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Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith 원문보기

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Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith 원문보기

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