Real-time volume confirmation dispensing apparatus and methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-035/10
G01N-009/00
G01L-009/00
출원번호
US-0766729
(2014-02-14)
등록번호
US-9989551
(2018-06-05)
국제출원번호
PCT/US2014/016564
(2014-02-14)
국제공개번호
WO2014/127277
(2014-08-21)
발명자
/ 주소
Wang, Litao
Hsieh, Pei-Ying
출원인 / 주소
Siemens Healthcare Diagnostics Inc.
인용정보
피인용 횟수 :
0인용 특허 :
16
초록▼
A method of confirming volume during dispensing of a liquid using pressure. The method includes attempting to dispense a volume of the liquid from a dispense port, measuring a pressure associated with the attempted dispense of the liquid and providing a measured pressure signal, determining a liquid
A method of confirming volume during dispensing of a liquid using pressure. The method includes attempting to dispense a volume of the liquid from a dispense port, measuring a pressure associated with the attempted dispense of the liquid and providing a measured pressure signal, determining a liquid dispensing start time and a stop time based on a slope of the measured pressure signal, integrating the measured pressure signal between the start time and the stop time to provide an integrated pressure value, and comparing the integrated pressure value to one or more preset threshold values. Liquid dispensing apparatus are provided, as are other aspects.
대표청구항▼
1. A method of detecting pressure during dispensing of a liquid, comprising: measuring the pressure of the liquid prior to dispensing the liquid from a dispense port to generate a reference pressure signal;dispensing a volume of the liquid from the dispense port;measuring the pressure of the liquid
1. A method of detecting pressure during dispensing of a liquid, comprising: measuring the pressure of the liquid prior to dispensing the liquid from a dispense port to generate a reference pressure signal;dispensing a volume of the liquid from the dispense port;measuring the pressure of the liquid over a time period during the dispensing and providing a pressure signal in response to the measuring;subtracting the reference pressure signal from the pressure signal to generate a measured pressure signal;determining a start time when dispensing starts and a stop time when dispensing stops based on a slope of the measured pressure signal;integrating the measured pressure signal between the start time and the stop time to provide an integrated pressure value; andcomparing the integrated pressure value to one or more preset threshold pressure values. 2. The method of claim 1, comprising: performing one or more experimental measurements of the pressure of the liquid during experimental dispensing, anddetermining a predetermined nominal integrated pressure value based on the one or more experimental measurements,wherein comparing the integrated pressure value to one or more preset threshold pressure values comprises comparing the integrated pressure value to one or more preset threshold pressure values having a setting of less than the predetermined nominal integrated pressure value. 3. The method of claim 1, wherein comparing the integrated pressure value to one or more preset threshold pressure values comprises: performing one or more experimental measurements of the pressure of the liquid during experimental dispensing,determining a predetermined nominal integrated pressure value based on the one or more experimental measurements,comparing the integrated pressure value to a lower threshold pressure value that is less than the predetermined nominal integrated pressure value, andcomparing the integrated pressure value to an upper threshold pressure value that is greater than the predetermined nominal integrated pressure value. 4. The method of claim 1, wherein comparing the integrated pressure value to one or more preset threshold pressure values comprises: performing one or more experimental measurements of the pressure of the liquid during experimental dispensing,determining a predetermined nominal integrated pressure value based on the one or more experimental measurements, andcomparing the integrated pressure value to a threshold pressure value that is less than +/−5% from the predetermined nominal integrated pressure value. 5. The method of claim 1, wherein comparing the integrated pressure value to one or more preset threshold pressure values comprises: performing one or more experimental measurements of the pressure of the liquid during experimental dispensing,determining a predetermined nominal integrated pressure value based on the one or more experimental measurements, andcomparing the integrated pressure value to a threshold pressure value that is less than +/−2% from the predetermined nominal integrated pressure value. 6. The method of claim 1, further comprising detecting, in response to the comparing, one or more of: an air bubble,a system leak, anda valve failure. 7. The method of claim 1, further comprising detecting a presence of a blockage in response to the comparing. 8. The method of claim 1, wherein the dispensing the volume of the liquid from the dispense port comprises dispensing one or more of: an acid; ora base. 9. The method of claim 1, wherein the dispensing comprises dispensing the liquid into a reaction cuvette. 10. The method of claim 1, wherein the pressure of the liquid is continuously measured during the dispensing. 11. The method of claim 1, wherein if the integrated pressure value is outside the one or more preset threshold pressure values, then one of: an alert is indicated; andthe dispensing is stopped. 12. The method of claim 1, wherein the start time is determined by estimating a slope of the measured pressure signal, and wherein the start time occurs when the estimated slope exceeds a start threshold pressure value. 13. The method of claim 1, wherein the stop time is determined by estimating a slope of the measured pressure signal, and wherein the stop time occurs when the estimated slope exceeds a stop threshold pressure value. 14. The method of claim 1, comprising: determining a first measured pressure signal of the liquid being dispensed at a beginning of a time window;determining a second measured pressure signal of the liquid being dispensed at an end of the time window;determining a difference between the first measured pressure signal and the second measured pressure signal; anddetermining the start time of the dispensing as occurring when the difference between the first measured pressure signal and the second measured pressure signal exceeds a start threshold pressure signal value. 15. The method of claim 1, comprising: determining a first measured pressure signal of the liquid being dispensed at a beginning of a time window;determining a second measured pressure signal of the liquid being dispensed at an end of the time window;determining a difference between the first measured pressure signal and the second measured pressure signal; anddetermining the stop time of the dispensing as occurring when the difference between the first measured pressure signal and the second measured pressure signal exceeds a stop threshold pressure signal value.
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이 특허에 인용된 특허 (16)
Takeda Masaaki (Mitaka JPX) Kato Yuko (Mitaka JPX) Pelletier Brent A. (Mundelein IL), Automatic pipetting apparatus with leak detection and method of detecting a leak.
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