Near-infrared super-continuum lasers for early detection of breast and other cancers
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
출원번호
US-0109007
(2013-12-17)
등록번호
US-9993159
(2018-06-12)
발명자
/ 주소
Islam, Mohammed N.
출원인 / 주소
OMNI MEDSCI, INC.
대리인 / 주소
Brooks Kushman P.C.
인용정보
피인용 횟수 :
0인용 특허 :
143
초록▼
A system and method for using near-infrared or short-wave infrared (SWIR) light sources for early detection and monitoring of breast cancer, as well as other kinds of cancers may detect decreases in lipid content and increases in collagen content, possibly with a shift in the collagen peak wavelengt
A system and method for using near-infrared or short-wave infrared (SWIR) light sources for early detection and monitoring of breast cancer, as well as other kinds of cancers may detect decreases in lipid content and increases in collagen content, possibly with a shift in the collagen peak wavelengths and changes in spectral features associated with hemoglobin and water content as well. Wavelength ranges between 1000-1400 nm and 1600-1800 nm may permit relatively high penetration depths because they fall within local minima of water absorption, scattering loss decreases with increasing wavelength, and they have characteristic signatures corresponding to overtone and combination bands from chemical bonds of interest, such as hydrocarbons. Broadband light sources and detectors permit spectroscopy in transmission, reflection, and/or diffuse optical tomography. High signal-to-noise ratio may be achieved using a fiber-based super-continuum light source. Risk of pain or skin damage may be mitigated using surface cooling and focused infrared light.
대표청구항▼
1. A diagnostic system comprising: a light source configured to generate an output optical beam, comprising: one or more semiconductor sources configured to generate an input beam;one or more optical amplifiers configured to receive at least a portion of the input beam and to deliver an intermediate
1. A diagnostic system comprising: a light source configured to generate an output optical beam, comprising: one or more semiconductor sources configured to generate an input beam;one or more optical amplifiers configured to receive at least a portion of the input beam and to deliver an intermediate beam to an output end of the one or more optical amplifiers;one or more optical fibers configured to receive at least a portion of the intermediate beam and to deliver at least the portion of the intermediate beam to a distal end of the one or more optical fibers to form a first optical beam;a nonlinear element configured to receive at least a portion of the first optical beam and to broaden a spectrum associated with the at least a portion of the first optical beam to at least 10 nanometers through a nonlinear effect in the nonlinear element to form the output optical beam with an output beam broadened spectrum; andwherein at least a portion of the output beam broadened spectrum comprises a short-wave infrared wavelength between approximately 1000 nanometers and approximately 1400 nanometers or between approximately 1600 nanometers and approximately 1800 nanometers, and wherein at least a portion of the one of more fibers is a fused silica fiber with a core diameter less than approximately 400 microns;an interface device configured to receive a received portion of the output optical beam and configured to deliver a delivered portion of the output optical beam to a tissue sample, wherein the delivered portion of the output optical beam is configured to generate a diffuse spectroscopy output beam from the tissue sample that results from light diffusion into a top two (2) millimeters or more of the tissue sample; and a receiver configured to receive at least a portion of the spectroscopy output beam having a bandwidth of at least 10 nanometers and configured to process the portion of the spectroscopy output beam to generate an output signal that monitors absorption or scattering features at least in part from a composition of collagen and lipids in the tissue sample. 2. The system of claim 1, wherein the spectroscopy output beam is based at least in part on diffuse light spectroscopy, and the tissue sample is breast, skin, prostate, brain, pancreatic or colorectal tissue. 3. The system of claim 1, wherein the semiconductor sources are selected from the group consisting of semiconductor lasers, super-luminescent diodes, and light emitting diodes. 4. The system of claim 1, wherein the interface device further comprises a surface cooling apparatus or a light focusing apparatus. 5. The system of claim 1, wherein the receiver further comprises a Fourier transform infrared (FTIR) spectrometer or a dispersive spectrometer. 6. A method of measuring, comprising: generating an output optical beam, comprising: generating an input optical beam from a plurality of semiconductor sources;multiplexing at least a portion of the input optical beam and forming an intermediate optical beam; andguiding at least a portion of the intermediate optical beam and forming the output optical beam, wherein the output optical beam comprises one or more optical wavelengths, wherein at least a portion of the optical wavelengths is between approximately 1000 nanometers and 1400 nanometers or between approximately 1600 nanometers and 1800 nanometers;receiving a received portion of the output optical beam and delivering a delivered portion of the output optical beam to a tissue sample;generating a diffuse spectroscopy output beam having a bandwidth of at least 10 nanometers that results from light diffusion into a top two (2) millimeters or more of the tissue sample;receiving at least a portion of the diffuse spectroscopy output beam; andprocessing the portion of the spectroscopy output beam and generating an output signal based on a wavelength dependence of the spectroscopy output beam over the bandwidth of at least 10 nanometers, and wherein the output signal is based on intrinsic tissue contrast of the tissue sample. 7. The method of claim 6, wherein at least a part of the delivered portion of the output optical beam penetrates the tissue sample by two (2) millimeters or more, and wherein the spectroscopy output beam is based on diffuse reflection light spectroscopy. 8. The method of claim 6, further comprising cooling at least a part of the tissue sample or focusing the delivered portion of the output optical beam onto the tissue sample. 9. The method of claim 6, wherein the output signal is configured to diagnose cancer in at least a part of the tissue sample based on an increase of collagen signature or decrease of lipid signature within the tissue sample.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (143)
Hazen, Kevin H.; Acosta, George; Abul-Haj, N. Alan; Abul-Haj, Roxanne E., Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling.
Fermann Martin E. ; Galvanauskas Almantas ; Harter Donald J., Apparatus and method for the generation of high-power femtosecond pulses from a fiber amplifier.
Ruchti, Timothy L.; Hazen, Kevin H.; Makarewicz, Marcy R.; Acosta, George M., Classification and characterization of tissue through features related to adipose tissue.
Mattu, Mutua; Blank, Thomas B.; Makarewicz, Marcy R.; Rosenhan, Branden, Classification and screening of test subjects according to optical thickness of skin.
Acosta, George M.; Henderson, James R.; Abul Haj, N. Alan; Ruchti, Timothy L.; Monfre, Stephen L.; Blank, Thomas B.; Hazen, Kevin H., Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy.
Acosta,George M.; Henderson,James R.; Abul Haj,N. Alan; Ruchti,Timothy L.; Monfre,Stephen L.; Blank,Thomas B.; Hazen,Kevin H., Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy.
Donald V. Smart ; Donald J. Svetkoff, Energy-efficient method and system for processing target material using an amplified, wavelength-shifted pulse train.
Lerner Ethan A. (20 St. Paul St. Brookline MA 02146) Anderson R. Rox (7 Campbell Park Somerville MA 02144) Lerner Michael R. (27 Jayne La. Hamden CT 06514), Fiber optic psoriasis treatment device.
Dempsey Michael K. (Acton MA) Kotfila Mark S. (Chelmsford MA) Snyder Robert J. (Westford MA), Flexible patient monitoring system featuring a multiport transmitter.
Hashim, Sami A.; Jusis, Joanna; Heydinger Galante, Jenifer; Rongione, Joseph C., Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose.
Glassman Edward (New York NY) Hanson William A. (Mountain View CA) Kazanzides Peter (Davis CA) Mittelstadt Brent D. (Placerville CA) Musits Bela L. (Hopewell Junction NY) Paul Howard A. (Loomis CA) T, Image-directed robotic system for precise robotic surgery including redundant consistency checking.
Glassman Edward (New York NY) Hanson William A. (Mountain View CA) Kazanzides Peter (Davis CA) Mittelstadt Brent D. (Placerville CA) Musits Bela L. (Hopewell Junction NY) Paul Howard A. (Loomis CA) T, Image-directed robotic system for precise robotic surgery including redundant consistency checking.
Ruchti, Timothy L.; Briggs, Christopher C.; Blank, Thomas B.; Lorenz, Alexander D.; Mattu, Mutua; Makarewicz, Marcy, Intelligent system for detecting errors and determining failure modes in noninvasive measurement of blood and tissue analytes.
Allen George S. (628 Westview Ave. Nashville TN 37205) Galloway ; Jr. Robert L. (7736 Indian Springs Dr. Nashville TN 37221) Maciunas Robert J. (6320 Chickering Woods La. Nashville TN 37215) Edwards , Interactive image-guided surgical system.
Lorenz,Alexander D.; Ruchti,Timothy L.; Blank,Thomas B.; Hazen,Kevin H., Measurement site dependent data preprocessing method for robust calibration and prediction.
Louis C. Cosentino ; Michael John Duea ; Duane Robert Duea ; Steven George Dorfe ; Daniel L. Cosentino, Medical wellness parameters management system, apparatus and method.
Ruchti, Timothy L.; Lorenz, Alexander D.; Hazen, Kevin H., Method and apparatus for enhanced estimation of an analyte property through multiple region transformation.
Makarewicz, Marcy R.; Mattu, Mutua; Blank, Thomas B.; Monfre, Stephen L.; Ruchti, Timothy L., Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination.
Yulun Wang ; Darrin Uecker ; Keith Laby ; Jeff Wilson ; Charles Jordan ; James Wright ; Modjtaba Ghodoussi, Method and apparatus for performing minimally invasive surgical procedures.
Islam, Mohammed N.; Boyraz, Ozdal; Kim, Jaeyoun, Method and system for generating a broadband spectral continuum and continuous wave-generating system utilizing same.
Mohammed N. Islam ; Ozdal Boyraz ; Jaeyoun Kim, Method and system for generating a broadband spectral continuum and continuous wave-generating system utilizing same.
Islam, Mohammed N.; Nowak, George A.; Kim, Jaeyoun, Method and system for generating a broadband spectral continuum, method of making the system and pulse-generating system utilizing same.
Mohammed N. Islam ; George A. Nowak ; Jaeyoun Kim, Method and system for generating a broadband spectral continuum, method of making the system and pulse-generating system utilizing same.
Lai Joseph ; Buyan Lawrence A. ; DuBore Renee S. ; Pate Brian Lewis ; Reuss James L., Method and system for remotely monitoring multiple medical parameters.
Hazen, Kevin H.; Blank, Thomas B.; Monfre, Stephen; Ruchti, Timothy L., Method of characterizing spectrometer instruments and providing calibration models to compensate for instrument variation.
Blank, Thomas B.; Acosta, George M.; Ruchti, Timothy L.; Mattu, Mutua; Lorenz, Alexander D.; Hazen, Kevin H.; Henderson, James R., Noninvasive analyzer sample probe interface method and apparatus.
Ruchti,Timothy L.; Thennadil,Suresh N.; Blank,Thomas B.; Lorenz,Alexander; Monfre,Stephen L., Noninvasive measurement of glucose through the optical properties of tissue.
Arai, Tsunenori; Kawase, Yuki; Oka, Yasunobu; Ito, Narushi, Noninvasive measuring device for substance in blood via nail and a nail evaporation device.
Monfre, Stephen L.; Blank, Thomas B.; Hazen, Kevin H.; Abul-Haj, Alan; Ruchti, Tim; Henderson, James Ryan; Stippick, Tim; Abul-Haj, Roxanne, Noninvasive targeting system method and apparatus.
Gnauck Alan H. (Middletown NJ) Kurtzke Christian (Hazlet NJ), Optical communication using dispersion-induced FM to AM conversion with nonlinearity-induced stabilization.
Blank,Thomas B.; Acosta,George; Mattu,Mutua; Makarewicz,Marcy; Monfre,Stephen L.; Lorenz,Alexander D.; Ruchti,Timothy L., Optical sampling interface system for in vivo measurement of tissue.
Coughlan Joel B. (Knox County TN) Harvey Howard W. (Roane County TN) Upton R. Glen (Anderson County TN) White John R. (Roane County TN), Remote manipulator.
Funda Janez (Valhalla NY) LaRose David A. (Croton on Hudson NY) Taylor Russell H. (Ossining NY), Robotic system for positioning a surgical instrument relative to a patient\s body.
Narayannan Krishna (423 N. St. Clair Pittsburgh PA 15206) Liang Marc D. (6801 Linden La. Pittsburgh PA 15206) Kurtz John L. (983 Centennial Dr. Indiana PA 15701), Voice activated control apparatus.
Brant Arthur ; Mandell Kenneth ; Rader R. Scott ; Walsh Alexander ; deJuan ; Jr. Eugene ; Greenberg Robert, Voice command and control medical care system.
Brant Arthur ; Mandell Kenneth ; Rader R. Scott ; Walsh Alexander ; deJuan ; Jr. Eugene ; Greenberg Robert, Voice command and control medical care system.
Tunnell George (667 Sandy Hook Ct. Foster City CA 94404) Pomernacki Charles L. (4162 Barner Ave. Oakland CA 94602) Gregg Jack P. (2371 Lockwood Ave. Fremont CA 94538), Voice controlled welding system.
Carter, Scott J.; Flanders, Edward L.; Hannah, Stephen E., Wireless LAN architecture for integrated time-critical and non-time-critical services within medical facilities.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.