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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0429022 (2017-02-09) |
등록번호 | US-9993186 (2018-06-12) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 374 |
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic rea
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
1. A system for continuous in vivo measurement of a glucose concentration in a host, the system comprising: an implantable sensor configured to generate in vivo a signal indicative of a concentration of glucose in a host;a membrane located over the sensor, the membrane comprising: a first domain com
1. A system for continuous in vivo measurement of a glucose concentration in a host, the system comprising: an implantable sensor configured to generate in vivo a signal indicative of a concentration of glucose in a host;a membrane located over the sensor, the membrane comprising: a first domain comprising an enzyme configured to catalyze a reaction that has glucose as a reactant; anda second domain configured to provide an interface with a biological fluid, wherein the second domain comprises a material having an oxygen solubility that is about 3-10 times higher than an oxygen solubility of water;sensor electronics configured to operatively connect with the implantable sensor and to process the signal and determine a glucose concentration value. 2. The implantable device of claim 1, wherein the material of the second domain has an oxygen permeability of from about 5 Barrers to about 500 Barrers. 3. The implantable device of claim 1, wherein the material of the second domain has an oxygen permeability of from about 25 Barrers to about 250 Barrers. 4. The implantable device of claim 1, wherein the membrane has a thickness of from about 3 microns to about 100 microns. 5. The implantable device of claim 1, wherein the membrane further comprises a third domain configured to limit or block passage of an interfering species therethrough. 6. The implantable device of claim 1, wherein the material of the second domain comprises a copolymer comprising polyurethane and silicone. 7. The implantable device of claim 1, wherein the material has an oxygen solubility that is at least about four times greater than an oxygen solubility of water. 8. The implantable device of claim 1, wherein the material has an oxygen solubility that is about five times greater than an oxygen solubility of water. 9. The implantable device of claim 1, wherein the material has an oxygen solubility that is about six times greater than an oxygen solubility of water. 10. The implantable device of claim 1, wherein the material has an oxygen solubility that is about seven times greater than an oxygen solubility of water. 11. The implantable device of claim 1, wherein the material has an oxygen solubility that is about nine times greater than an oxygen solubility of water. 12. The implantable device of claim 1, wherein the material has an oxygen solubility that is about ten times greater than an oxygen solubility of water.
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