Embolization device constructed from expansile polymer
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/01
A61B-017/12
A61L-031/04
A61L-031/06
A61L-031/14
출원번호
US-0911562
(2010-10-25)
등록번호
US-9993252
(2018-06-12)
발명자
/ 주소
Keeley, E. Michael
Cruise, Gregory M.
Constant, Michael J.
Warner, Sheila
Walker, Maricela
출원인 / 주소
MicroVention, Inc.
대리인 / 주소
K&L Gates LLP
인용정보
피인용 횟수 :
0인용 특허 :
170
초록▼
Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may include novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deploymen
Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may include novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, or similar structures.
대표청구항▼
1. A device for implantation in an animal comprising: a carrier member having a distal end and a proximal end, wherein the carrier member includes helical coils close to each other at the distal end and at the proximal end and having larger gaps between the distal end and the proximal end, and where
1. A device for implantation in an animal comprising: a carrier member having a distal end and a proximal end, wherein the carrier member includes helical coils close to each other at the distal end and at the proximal end and having larger gaps between the distal end and the proximal end, and wherein the proximal end includes laterally a first larger coil diameter, a second smaller coil diameter, and a third larger coil diameter;a hydrogel filament having ionizable functional groups wherein said hydrogel filament comprises a macromer of about 48% poly(ethylene glycol) di-acrylamide and a pH sensitive component of about 52% sodium acrylate, and wherein the hydrogel filament includes a proximal end, a distal end, and a pathway along a center of the hydrogel filament,a stretch resistant member disposed within the pathway and wrapped around at least a portion of the distal end and the proximal end of the carrier member, andan adhesive at the distal end and the proximal end that encapsulates the proximal end and the distal end of the hydrogel filament, the carrier member, and the stretch resistant member. 2. The device according to claim 1 wherein said macromer is cross-linked with at least one ethylenically unsaturated compound. 3. The device according to claim 1 wherein said macromer is cross-linked with N,N′-methylenebisacrylamide, derivatives thereof, or combinations thereof. 4. The device according to claim 1 wherein said hydrogel includes pores created by a porosigen. 5. The device according to claim 4 wherein said porosigen is about 0.4 g/g sodium chloride. 6. The device according to claim 5 wherein said sodium chloride has a particle size of about 10 microns. 7. The device according to claim 1 wherein said larger gaps range from about 0.0015″ to about 0.00750″. 8. The device according to claim 7 wherein said larger gaps comprise 0.003″. 9. The implant device of claim 1 wherein said hydrogel expands from a diameter of about 0.006″-0.007″ to a diameter of about 0.02″ after expansion. 10. The device of claim 1 wherein the stretch resistant member is wrapped around two separate helical coils at the proximal end of the carrier member. 11. A device for implantation in an animal comprising: a carrier member having a distal end and a proximal end, wherein the carrier member includes helical coils close to each other at the distal end and at the proximal end and have larger gaps between the distal end and the proximal end, wherein the proximal end includes laterally a first larger coil diameter, a second smaller coil diameter, and a third larger coil diameter, and wherein the larger gaps range from about 0.0015″ to about 0.00750″; anda hydrogel filament comprising at least a macromer of about 48% poly(ethylene glycol) di-acrylamide and a pH sensitive component of about 52% sodium acrylate, and wherein the hydrogel filament includes a proximal end, a distal end, and a pathway along a center of the hydrogel filament,a stretch resistant member disposed within the pathway and wrapped around at least a portion of the distal end and the proximal end of the carrier member, andan adhesive at the distal end and the proximal end that encapsulates the proximal end and the distal end of the hydrogel filament, the carrier member, and the stretch resistant member. 12. The implant device of claim 11, wherein said hydrogel includes pores created by a porosigen. 13. The implant device of claim 12, wherein said porosigen is about 0.4 g/g sodium chloride. 14. The implant device of claim 13, wherein said sodium chloride has a particle size of about 10 microns. 15. The device according to claim 11 wherein said larger gaps comprise 0.003″. 16. The implant device of claim 11 wherein said hydrogel expands from a diameter of about 0.006″-0.007″ to a diameter of about 0.02″ after expansion. 17. The device of claim 11 wherein the stretch resistant member is wrapped around two separate helical coils at the proximal end of the carrier member. 18. An implant device comprising: a carrier member having a distal end and a proximal end, wherein the carrier member includes helical coils close to each other at the distal end and at the proximal end and have larger gaps between the distal end and the proximal end, wherein the proximal end includes laterally a first larger coil diameter, a second smaller coil diameter, and a third lamer coil diameter, and wherein the larger spaces have a gap of about 0.003″;a hydrogel member including a proximal end, a distal end, and a pathway along a center of the hydrogel member, wherein the hydrogel member is disposed within said carrier member;a stretch resistant member disposed within the pathway of said hydrogel member and wrapped around at least a portion of the distal end and the proximal end of said carrier member; and,an adhesive at the distal end and the proximal end that encapsulates the proximal end and the distal end of the hydrogel member, the carrier member, and the stretch resistant member,wherein said hydrogel comprises a macromer of about 48% poly(ethylene glycol) di-acrylamide and a pH sensitive component of about 52% sodium acrylate. 19. The implant device of claim 18 wherein said hydrogel expands from a diameter of about 0.006″-0.007″ to a diameter of about 0.02″ after expansion. 20. The implant device of claim 18 wherein the stretch resistant member is wrapped around two separate helical coils at the proximal end of the carrier member.
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