Method for use of a double-structured tissue implant for treatment of tissue defects
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
A61L-027/54
A61L-027/34
A61L-027/24
A61L-027/36
A61F-002/30
A61L-027/48
A61L-027/56
C07K-014/78
A61L-027/44
출원번호
US-0834951
(2015-08-25)
등록번호
US-9993326
(2018-06-12)
발명자
/ 주소
Shortkroff, Sonya
Tarrant, Laurence J. B.
Roos, Eric J.
Smith, Robert Lane
Claesson, Hans P. I.
출원인 / 주소
Histogenics Corporation
대리인 / 주소
Troutman Sanders LLP
인용정보
피인용 횟수 :
0인용 특허 :
115
초록▼
A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic su
A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.
대표청구항▼
1. An implant for repairing a cartilage or a tissue defect comprising: a three-dimensional primary scaffold comprising collagen and defining a plurality of pores, wherein the primary scaffold defines a top surface and a bottom surface of the implant; anda secondary scaffold comprising lyophilized an
1. An implant for repairing a cartilage or a tissue defect comprising: a three-dimensional primary scaffold comprising collagen and defining a plurality of pores, wherein the primary scaffold defines a top surface and a bottom surface of the implant; anda secondary scaffold comprising lyophilized and dehydrothermally treated collagen and a surfactant, wherein the secondary scaffold forms a fibrous and cross-linked collagen network within the plurality of pores. 2. The implant of claim 1, wherein the secondary scaffold has been lyophilized at a temperature of about −10° C. to about −210° C. over a period of about 2 to about 60 minutes and dehydrothermally treated at a temperature of about 70° C. to about 200° C. for about 30 minutes to about 7 days. 3. The implant of claim 2, wherein the pores are substantially uniform in size with a diameter of about 300±100 μm. 4. The implant of claim 3, wherein the sizes and diameters of the pores on both the top surface and the bottom surface are substantially the same. 5. The implant of claim 4, wherein the pores are vertically oriented. 6. The implant of claim 1, wherein the secondary scaffold comprises Type I collagen. 7. The implant of claim 1, wherein the surfactant is a derivatized polyethylene glycol. 8. The implant of claim 7, wherein the derivatized polyethylene glycol is polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether. 9. The implant of claim 1, wherein the surfactant is a block co-polymer of polyoxyethylene (PEO) and polyoxypropylene (PPO) having the generic organization of polymeric blocks PEG-PPO-PEG or PPO-PEG-PPO. 10. The implant of claim 9, wherein the block co-polymer is a polymer of polyoxyethylene (PEO) and polyoxypropylene (PPO) with two 96-unit hydrophilic PEO chains surrounding one 69-unit hydrophobic PPO chain. 11. The implant of claim 1, further comprising a morphogenetic growth factor incorporated therein. 12. The implant of claim 1, further comprising a modulator incorporated therein. 13. The implant of claim 1, further comprising a pharmaceutical agent, a growth factor, a growth hormone, a mediator, an enzyme promoting cell incorporation, an enzyme promoting cell proliferation, an enzyme promoting cell division, a pharmaceutically acceptable excipient, an additive, a buffer, a transforming growth factor, an insulin-like growth factor 1, a platelet-derived growth factor, a repulsive guidance molecule, or a bone morphogenetic protein (BMP). 14. The implant of claim 1, wherein the secondary scaffold has been dehydrated by a dehydrothermal treatment comprising subjecting the secondary scaffold to a temperature between about 70° C. to about 200° C., for about 30 minutes to about 7 days, under a vacuum. 15. An implant for repairing a cartilage or a tissue defect comprising: a three-dimensional primary scaffold comprising type I collagen and defining a plurality of pores, wherein the primary scaffold defines a top surface and a bottom surface of the implant;a secondary scaffold comprising lyophilized and dehydrothermally treated collagen, wherein the secondary scaffold forms a fibrous and cross-linked collagen network within the plurality of pores, wherein the pores are substantially uniform in size with a diameter of about 300±100 μm, and wherein the sizes and diameters of the pores on both the top surface and the bottom surface are substantially the same; anda cell modulator incorporated within the implant. 16. The implant of claim 15, wherein the secondary scaffold has been lyophilized at a temperature of about −10° C. to about −210° C. over a period of about 2 to about 60 minutes and dehydrothermally treated at a temperature between about 70° C. to about 200° C., for about 30 minutes to about 7 days, under a vacuum. 17. The implant of claim 16, wherein the cell modulator comprises a bone morphogenetic protein (BMP).
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