Devices and methods for vestibular and/or cranial nerve stimulation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-018/18
A61F-007/12
A61F-007/00
출원번호
US-0099059
(2013-12-06)
등록번호
US-9993366
(2018-06-12)
발명자
/ 주소
Smith, Lanty L.
Rogers, Lesco L.
출원인 / 주소
SCION NEUROSIM, LLC
대리인 / 주소
Myers Bigel, PA
인용정보
피인용 횟수 :
0인용 특허 :
22
초록▼
An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; a
An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.
대표청구항▼
1. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: (a) an earpiece configured to be insertable into the ear canal of said subject, said earpiece having an outer surface and an internal cavity formed therein, said internal cavity having an inner s
1. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: (a) an earpiece configured to be insertable into the ear canal of said subject, said earpiece having an outer surface and an internal cavity formed therein, said internal cavity having an inner surface;(b) at least one thermoelectric device thermally coupled to said earpiece internal cavity inner surface;(c) a heat sink positioned in said earpiece internal cavity, wherein said heat sink is thermally coupled to said at least one thermoelectric device; and(d) further comprising a controller configured to deliver a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject, wherein the controller is configured to deliver the time-varying thermal waveform such that the time-varying thermal waveform comprises an amplitude that increases or decreases through a plurality of different temperature points over time. 2. The stimulator of claim 1, wherein the at least one thermoelectric device is positioned in the internal cavity. 3. The stimulator of claim 1, further comprising a removable sleeve that is connected to the outer surface of the earpiece that is configured to engage the ear canal of the subject. 4. The stimulator of claim 3, wherein the removable sleeve comprises a compressible material and the earpiece comprises a rigid material. 5. The stimulator of claim 1, wherein the earpiece is customized for an individual subject. 6. The stimulator of claim 1, wherein said heat sink comprises an inner portion extending into said earpiece and having a generally planar surface, said earpiece internal surface having a corresponding cooperating planar surface, said at least one thermoelectric device being mounted between said heat sink planar surface and said cooperating portion of said earpiece inner surface. 7. The stimulator of claim 6, wherein said heat sink comprises a side portion that generally conforms to a corresponding side portion of said inner surface of said internal cavity, said at least one thermoelectric device being mounted between said side portion of said heat sink and said side portion of said inner surface of said internal cavity. 8. The stimulator of claim 1, wherein said heat sink comprises an inner portion received in said earpiece internal cavity, and wherein a shape of said inner portion substantially corresponds to a shape of said internal cavity. 9. The stimulator of claim 8, wherein said heat sink comprises an outer portion positioned outside of said earpiece internal cavity. 10. The stimulator of claim 1, wherein said earpiece is formed from a rigid, thermally-conductive material. 11. The stimulator of claim 1, wherein said earpiece comprises aluminum. 12. The stimulator of claim 1, wherein the at least one thermoelectric device comprises a plurality of thermoelectric devices. 13. The stimulator of claim 12, wherein said plurality of thermoelectric devices are thermally coupled to one another. 14. The stimulator of claim 1, wherein said at least one thermoelectric device comprises a thin film thermoelectric device. 15. The stimulator of claim 1, wherein said earpiece comprises an elongated conical portion configured to be insertable into the ear canal. 16. The stimulator of claim 15, wherein said earpiece comprises a conical apex of the conical portion that has been blunted to form a dome-shaped point. 17. The stimulator of claim 16, wherein said earpiece comprises: a generally cylindrical base having opposite first and second ends, the base defining a longitudinal centerline; andan extended portion extending from the second end of the cylindrical base, wherein said dome-shaped point is offset from the longitudinal centerline. 18. The stimulator of claim 17, wherein the cross-sectional area of the extended portion decreases as a function of distance away from said base. 19. The stimulator of claim 18, wherein the extended portion tapers unevenly from said cylindrical base to said dome-shaped point. 20. The stimulator of claim 1, further comprising a head piece, wherein said head piece is configured for positioning the earpiece in the ear canal of the subject. 21. The stimulator of claim 1, further comprising a removable sheath having an inner surface portion configured to conformably engage the earpiece and an outer surface to conformably engage the ear canal of the subject. 22. A method for delivering caloric stimulation to a subject, the method comprising: providing an in-ear stimulator comprising: (a) an earpiece configured to be insertable into the ear canal of said subject, said earpiece having an outer surface and an internal cavity formed therein, said internal cavity having an inner surface;(b) at least one thermoelectric device positioned in the internal cavity and thermally coupled to said earpiece internal cavity inner surface;(c) a heat sink positioned in said earpiece internal cavity, wherein said heat sink is thermally coupled to said at least one thermoelectric device; and(d) a controller configured to deliver a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject, wherein the controller is configured to deliver the time-varying thermal waveform such that the time-varying thermal waveform comprises an amplitude that increases or decreases through a plurality of different temperature points over time; andpositioning at least a portion of an in-ear stimulator in an ear canal of the subject. 23. The method of claim 22, wherein providing an in-ear stimulator comprises forming the earpiece in a custom shape according to the ear canal of said subject. 24. The method of claim 23, wherein providing an in-ear stimulator comprises providing a removable sleeve that is connected to the outer surface of the earpiece that is configured to engage the ear canal of the subject. 25. The method of claim 24, wherein the removable sleeve comprises a compressible material and the earpiece comprises a rigid material. 26. The method of claim 22, further comprising delivering a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject. 27. The method of claim 26, wherein said heat sink comprises an inner portion extending into said earpiece and having a generally planar surface, said earpiece internal surface having a corresponding cooperating planar surface, said at least one thermoelectric device being mounted between said heat sink planar surface and said cooperating portion of said earpiece inner surface. 28. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: (a) an earpiece configured to be insertable into the ear canal of said subject, said earpiece having an outer surface and an internal cavity formed therein, said internal cavity having an inner surface;(b) at least one thermoelectric device thermally coupled to said earpiece internal cavity inner surface; and(c) a controller configured to deliver a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject, wherein the controller is configured to deliver the time-varying thermal waveform such that the time-varying thermal waveform comprises an amplitude that increases or decreases through a plurality of different temperature points over time.
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