The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive
The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.
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1. A method of inducing anesthesia in a subject, comprising administering to the subject via the respiratory system an effective amount of 1,1,2,2,3,3,4,4-octafluoro-cyclohexane (CAS#830-15-9), thereby inducing anesthesia in the subject. 2. The method of claim 1, wherein the compound is administered
1. A method of inducing anesthesia in a subject, comprising administering to the subject via the respiratory system an effective amount of 1,1,2,2,3,3,4,4-octafluoro-cyclohexane (CAS#830-15-9), thereby inducing anesthesia in the subject. 2. The method of claim 1, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint, the desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 3. The method of claim 2, wherein the subject is a mammal. 4. The method of claim 2, wherein the subject is a human. 5. A method of inducing anesthesia in a subject, comprising administering to the subject an effective amount of 1,1,2,2,3,3,4,4-octafluoro-cyclohexane (CAS#830-15-9), thereby inducing anesthesia in the subject. 6. The method of claim 5, wherein the administering comprises administering by any route sufficient to achieve a desired anesthetic effect. 7. The method of claim 6, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint comprises a desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 8. The method of claim 6, wherein the subject is a mammal. 9. The method of claim 6, wherein the subject is a human. 10. The method of claim 5, wherein the compound is administered by a route selected from the group consisting of intravenous, inhalational, subcutaneous, intramuscular, and transdermal. 11. The method of claim 10, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint comprises a desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 12. The method of claim 10, wherein the subject is a mammal. 13. The method of claim 10, wherein the subject is a human. 14. The method of claim 5, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 15. The method of claim 14, wherein the subject is a mammal. 16. The method of claim 14, wherein the subject is a human.
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이 특허에 인용된 특허 (15)
Siegemund ; Gunter ; Muschaweck ; Roman, 1,2,2,2-Tetrafluoroethyl-fluoromethyl ether and process for preparing it.
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