Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/82
A61L-031/16
A61L-024/00
A61L-024/04
A61L-024/10
A61L-027/26
A61L-027/50
A61L-027/54
A61L-031/04
출원번호
US-0131083
(2009-11-17)
등록번호
US-10016534
(2018-07-10)
국제출원번호
PCT/US2009/064777
(2009-11-17)
§371/§102 date
20111017
(20111017)
국제공개번호
WO2010/057177
(2010-05-20)
발명자
/ 주소
Masters, David B.
출원인 / 주소
Gel-Del Technologies, Inc.
대리인 / 주소
Thompson, Craige
인용정보
피인용 횟수 :
0인용 특허 :
86
초록▼
The present invention relates to protein biocoacervates and biomaterials vessel graft systems used in cardiovascular applications and other medical applications, the components utilized in the vessel graft systems and the methods of making and using such systems. More specifically the present invent
The present invention relates to protein biocoacervates and biomaterials vessel graft systems used in cardiovascular applications and other medical applications, the components utilized in the vessel graft systems and the methods of making and using such systems. More specifically the present invention relates to protein biocoacervates and biomaterials vessel graft systems used in various medical applications and/or the devices used in such vessel graft systems including, but not limited to, vessel grafts as drug delivery devices for the controlled release of pharmacologically active agents, tubular grafts, vascular grafts, protein biomaterial sutures and biomeshes, protein biomaterial adhesives and glues, and other biocompatible biocoacervate or biomaterial devices used in the vessel graft systems of the present invention.
대표청구항▼
1. A vessel graft system comprising: one or more tube(s) including one or more components, at least one of the components including a first biomaterial formed from one or more precipitated amorphous thermoplastic biocoacervate(s), the biocoacervate(s) including one or more soluble or solubilized pri
1. A vessel graft system comprising: one or more tube(s) including one or more components, at least one of the components including a first biomaterial formed from one or more precipitated amorphous thermoplastic biocoacervate(s), the biocoacervate(s) including one or more soluble or solubilized primary proteins combined with one or more glycosaminoglycans and one or more biocompatible solvents and formed into a tubular configuration;one or more threads, sutures and/or wraps positioned at one or more end(s) of one or more of the tube(s); the threads, sutures and/or wraps comprising one or more pharmacologically active agents and a biomaterial formed from a one or more precipitated amorphous thermoplastic biocoacervate(s), the biocoacervate(s) including one or more soluble or solubilized primary proteins combined with one or more glycosaminoglycans and one or more biocompatible solvents, wherein the threads, sutures and/or wraps deliver the one or more pharmacologically active agents to an anastomosis site; and,a bioglue comprising a precipitated amorphous thermoplastic biocoacervate and one or more crosslinkers, the precipitated amorphous thermoplastic biocoacervate and one or more crosslinkers administered at the anastomosis site wherein the bioglue seals the threads, sutures and/or wraps at the anastomosis site. 2. The vessel graft system of claim 1 wherein the biocoacervates of the tube(s) and/or thread(s) are the same material. 3. The vessel graft system of claim 1 wherein the tube includes a structural scaffolding coated or encapsulated with the thermoplastic biomaterial. 4. The vessel graft system of claim 1 wherein the one or more primary proteins are selected from the group consisting of collagen, laminin, bone morphogenic protein and its isoforms that contain glycosaminoglycan binding sites, albumin, interleukins, epidermal growth factors, fibronectin, thrombin, aprotinin and antithrombin III. 5. The vessel graft system of claim 1 wherein the one or more glycosaminoglycans are selected from the group consisting of heparin, heparin sulfate, keratan sulfate, dermatin, dermatin sulfate, heparin-hyaluronic acid, chondroitin, chondroitin sulfate, chondroitin 6-sulfate, chondroitin 4-sulfate, chitin, chitosan, acetyl-glucosamine, hyaluronic acid, aggrecan, decorin, biglycan, fibromodulin, lumican and complexs thereof. 6. The vessel graft system of claim 1 wherein the tube further includes one or more secondary proteins. 7. The vessel graft system of claim 6 wherein the one or more secondary proteins are selected from the group consisting of fibrin, fibrinogen, elastin, albumin, ovalbumin, keratin, silk, silk fibroin, actin, myosin, thrombin, aprotinin and antithrombin III. 8. The vessel graft system of claim 1 wherein the one or more biocompatible solvents are selected from the group consisting of water, dimethyl sulfoxide (DMSO), biocompatible alcohols, biocompatible acids, oils and biocompatible glycols. 9. The vessel graft system of claim 1 wherein the one or more pharmacologically active agents are selected from the group consisting of analgesics, anesthetics, antiproliferative agents, angiogenesis inhibitors, angiogenic growth factors, steroids, antisteroids, corticosteroids, antiglacoma agents, antialcohol agents, anti-coagulant agents, genetic material, antithrombolytic agents, anticancer agents, anti-inflammatory agents, anticonception agents, enzymes agents, cells, growth factors, antiviral agents, antibacterial agents, antifungal agents and chemoattractants. 10. The vessel graft system of claim 9 wherein the one or more pharmacologically active agents are selected from the group consisting of paclitaxol, sirolimus, estradiol, dexamethazone, vitamin E, vitamin C, stem cells, superoxide dismutase, VEGF, FGF, EGF and cortizone. 11. The vessel graft system of claim 1 wherein the tube further includes one or more biocompatible additives. 12. The vessel graft system of claim 11 wherein the one or more biocompatible additives are selected from the group consisting of epoxies, polyesters, acrylics, nylons, silicones, polyanhydride, polyurethane, polycarbonate, poly(tetrafluoroethylene), polycaprolactone, polyalkenes, polyacrylates, bioceramic materials, polyethylene oxide, polyethylene glycol, poly(vinyl chloride), polylactic acid, polyglycolic acid, polypropylene oxide, poly(alkylene)glycol, polyoxyethylene, sebacic acid, polyvinyl alcohol, 2-hydroxyethyl methacrylate, polymethyl methacrylate, 1,3-bis(carboxyphenoxy)propane, lipids, phosphatidylcholine, triglycerides, polyhydroxybutyrate, polyhydroxyvalerate, poly(ethylene oxide), poly ortho esters, poly (amino acids), polycyanoacrylates, polyphophazenes, polysulfone, polyamine, poly (amido amines), glycosaminoglycans, bioceramic materials, insoluble proteins, proteins, amino acids, oils, fatty acids, salts, sugars, polypeptides, peptides, humectants, fibrin, graphite, flexible fluoropolymer, isobutyl-based, isopropyl styrene, vinyl pyrrolidone, cellulose acetate dibutyrate, silicone rubber, and copolymers of these. 13. The vessel graft system of claim 1 wherein the thermoplastic biomaterial is crosslinked with one or more crosslinking agents to form a crosslinked material. 14. The vessel graft system of claim 13 wherein the one or more cros slinking agents are selected from the group consisting of glutaraldehyde, 1,4-butandiol diglycidylether, formaldehyde, glyoxal, sebacic acid bis(N-succinimidyl) ester (DSS), p-Azidobenzolyl Hydazide, N-5-Azido 2-nitrobenzoyloxysuccinimide, N-Succinimidyl 6-[4′ azido-2′ nitro-phenylamino]hexanoate and 4-[p-Azidosalicylamido]butylamine. 15. The vessel graft system of claim 1 wherein the biomaterial included in the tube(s) and/or the thread(s) comprises collagen, heparin, elastin and water. 16. A vessel graft system comprising: one or more tube(s) including one or more components, at least one of the components including a first biomaterial formed from one or more precipitated amorphous thermoplastic biocoacervate(s), the biocoacervate(s) including one or more soluble or solubilized primary proteins combined with one or more glycosaminoglycans and one or more biocompatible solvents and formed into a tubular configuration;one or more threads, sutures and/or wraps positioned at one or more end(s) of one or more of the tube(s); the threads, sutures and/or wraps comprising one or more components, wherein at least one of the component(s) including a biomaterial formed from a one or more precipitated amorphous thermoplastic biocoacervate(s), the biocoacervate(s) including one or more soluble or solubilized primary proteins combined with one or more glycosaminoglycans and one or more biocompatible solvents; anda bioglue comprising a precipitated amorphous thermoplastic biocoacervate and one or more crosslinkers, wherein the bioglue seals the threads, sutures and/or wraps at an anastomosis site. 17. The vessel graft system of claim 16, wherein one or more threads, sutures and/or wraps further comprises one or more pharmacologically active agents and wherein the threads, sutures and/or wraps delivery the one or more pharmacologically active agents to the anastomosis site.
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Harvey Wilson (Sterling GBX) Light Nicholas D. (Doune Perthshire GBX) Haynes Carla A. (Glasgow GBX), Absorbable composite materials for use in the treatment of periodontal disease.
Rel Bernhard (Knigstein/Taunus DEX) Petri Walter (Niedernhausen/Taunus DEX), Base for mucosal and denture adhesive pastes, a process for the preparation thereof, and pastes having this base.
Schiraldi Michael T. (East Brunswick NJ) Perl Martin M. (Brooklyn NY) Rubin Howard (Rockaway NJ), Bioadhesive extruded film for intra-oral drug delivery and process.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Brendel Klaus (Tucson AZ) Duhamel Raymond C. (Tucson AZ), Body implants of extracellular matrix and means and methods of making and using such implants.
Yannas Ioannis V. (Newtown Center MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH) Silver Frederick H. (Danville NH) Burke John F. (Belmont MA), Crosslinked collagen-mucopolysaccharide composite materials.
Phipps Joseph B. (Plymouth MN) Howland Warren W. (Champlin MN) Jevne Allan H. (Anoka MN) Holmblad Carolann (Cambridge MN), Device and method for iontophoretic drug delivery.
David B. Masters, Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Orgill Dennis P. (Cambridge MA) Skrabut Eugene M. (Beverly MA), Method of promoting the regeneration of tissue at a wound.
Orgill Dennis P. (Belmont MA) Butler Charles E. (Brookline MA) Barlow Mark (Boston MA) Ritterbush Scott (Saugus MA) Yannas Ioannis V. (Newton MA) Compton Carolyn C. (Chestnut Hill MA), Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft.
Orgill Dennis P. ; Butler Charles E. ; Barlow Mark ; Ritterbush Scott ; Yannas Ioannis V. ; Compton Carolyn C., Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft.
Kizawa Hidenori (Tokyo JPX) Fujiyama Norimasa (Tokyo JPX) Kobayashi Jitsuo (Kanagawa JPX) Ito Akinori (Niigata JPX), Mucous membrane-adhering film preparation and process for its preparation.
Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH), Multilayer membrane useful as synthetic skin.
Casey Donald J. (Ridgefield CT) Huffman Kenneth R. (Stamford CT), Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same.
Hyon Suong-Hyu (Uji JPX) Ikada Yoshita (Uji JPX), Polylactic acid type microspheres containing physiologically active substance and process for preparing the same.
Cha Younsik (Salt Lake City UT) Choi Young Kweon (Salt Lake City UT) Pai Chaul Min (Taejon KRX), Preparation of peptide containing biodegradable microspheres by melt process.
Yannas Ioannis V. (Newton Center MA) Forbes Martin J. (Kirkland CAX), Procedures for preparing composite materials from collagen and glycosaminoglycan.
Yannas Ioannis V. (Newton MA) Orgill Dennis P. (Belmont MA) Loree ; II Howard M. (Cambridge MA) Kirk James F. (Cambridge MA) Chang Albert S. P. (Foster City MA) Mikic Borivoje B. (Cambridge MA) Kraru, Prosthesis for promotion of nerve regeneration.
Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX) Yamashita Gentaro (Koganei JPX), Slow-releasing medical preparation to be administered by adhering to a wet mucous surface.
Reiley Mark A ; Scholten Arie ; Talmadge Karen D ; Scribner Robert M, Systems and methods for treating fractured or diseased bone using expandable bodies.
Buysse Steven P. ; Kennedy Jenifer S. ; Lands Michael J. ; Loeffler Donald R. ; Lukianow S. Wade ; Ryan Thomas P., Vascular tissue sealing pressure control and method.
Biegajski James E. (Foster City CA) Venkatraman Subbu S. (Palo Alto CA) Scott Ann M. (Mountain View CA), Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavi.
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