A method of coating a material onto projections provided on a patch. The method includes applying a coating solution containing the material to at least the projections and drying the coating solution to at least the projections using a gas flow.
대표청구항▼
1. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein
1. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the coating solution has at least one of: a) a viscosity of between 10−3 Pa·S and 1 Pa·S; andb) a surface tension of between 0.023 N/m and 0.073 N/m. 2. A microprojection array according to claim 1, wherein the material includes at least one of: a) nanoparticles;b) a nucleic acid or protein;c) an antigen, allergen, or adjuvant;d) parasites, bacteria, viruses, or virus-like particles;e) quantum dots, SERS tags, Raman tags or other nanobiosensors;f) metals or metallic compounds; and,g) molecules, elements or compounds. 3. A microprojection array according to claim 1, wherein the coating solution further includes a therapeutic agent. 4. A microprojection array according to claim 3, wherein the therapeutic agent is at least one of: a) DNA; and,b) protein. 5. A microprojection array according to claim 1, wherein the coating solution includes the material and at least one of: a) a viscosity enhancer;b) a surfactant; orc) an adjuvant. 6. A microprojection array according to claim 5, wherein at least one of: a) the viscosity enhancer is 0% to 90% of the coating solution; and,b) the surfactant is 0% to 90% of the coating solution. 7. A microprojection array according to claim 5, wherein the viscosity enhancer is methylcellulose (MC), carboxymethylcellulose (CMC), gelatin, agar, agarose or any combination thereof. 8. A microprojection array according to claim 1, wherein the coating solution has a viscosity of 0.01-0.06 Pa·S. 9. A microprojection array according to claim 1, wherein the coating solution has a surface tension of 0.03-0.04 N/m. 10. A microprojection array according to claim 1, wherein the microprojections are provided on a patch having a surface area of approximately 0.16 cm2. 11. A microprojection array according to claim 1, wherein the microprojections have a length of between 10 to 400 μm. 12. A microprojection array according to claim 11, wherein the microprojections have a length of 90 μm. 13. A microprojection array according to claim 1 wherein the microprojections have a radius of curvature of greater than 1 μm. 14. A microprojection array according to claim 13, wherein the microprojections have a radius of curvature greater than 5 μm. 15. A microprojection array according to claim 1, wherein the microprojections include a support section and a targeting section. 16. A microprojection array according to claim 1, wherein the microprojections are solid. 17. A microprojection array according to claim 1, wherein the microprojections are non-porous and non-hollow. 18. A microprojection array according to claim 1, wherein the microprojection array is one of: a) hydrophobic; and,b) hydrophilic. 19. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, wherein the coating solution includes die material and at least one of a viscosity enhancer, a surfactant or an adjuvant, and wherein at least one of: a) the viscosity enhancer is 0% to 90% of the coating solution; and,b) the surfactant is 0% to 90% of the coating solution. 20. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, wherein the coating solution includes the material and at least one of a viscosity enhancer, a surfactant or an adjuvant, and wherein the viscosity enhancer is methylcellulose (MC), carboxymethylcellulose (CMC), gelatin, agar, agarose or any combination thereof. 21. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections are provided on a patch having a surface area of approximately 0.16 cm2. 22. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections have a radius of curvature of greater than 1 μm. 23. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections include a support section and a targeting section.
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