[특허]Bone grafts including osteogenic stem cells, and methods relating to the same

Bone grafts including osteogenic stem cells, and methods relating to the same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-035/28 A61L-027/38 A61L-027/36 A61K-035/32 C12N-005/077 C12N-005/0775 A61K-035/12
출원번호	US-0362889 (2016-11-29)
등록번호	US-10022474 (2018-07-17)
발명자 / 주소	Bhat, Archana Rao, Shairali Laskowitz, Daniel
출원인 / 주소	Globus Medical, Inc.
인용정보	피인용 횟수 : 0 인용 특허 : 132

초록 ▼

Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof. Also provided are kits that include the present bone grafts and/or constructs, or components thereof.

대표청구항 ▼

1. A method of treatment for bone healing comprising: administering to a mammal in need thereof a bone graft comprising osteogenic stem cells seeded on a scaffold, the scaffold including a mixture of osteoinductive demineralized cortical bone and osteoconductive non-demineralized cortico-cancellous chips without an additional natural or synthetic material, the cortico-cancellous chips obtained from condyles and the demineralized cortical bone obtained from cortical shafts of long bones, wherein the osteogenic stem cells are obtained from cells cultured from a mixture of bone marrow and cells from cancellous bone treated with collagenase, and the osteogenic stem cells are viable cells capable of bone regeneration. 2. The method of claim 1, wherein the osteogenic stem cells are present on the scaffold such that the bone graft has a seeding density of 20,000 to 100,000 cells/cm2. 3. The method of claim 1, wherein the osteogenic stem cells are mesenchymal stem cells. 4. The method of claim 3, wherein the mesenchymal stem cells are derived from a human source. 5. The method of claim 3, wherein the mesenchymal stem cells are derived from a bovine source. 6. The method of claim 1, wherein the bone graft has a putty-like consistency. 7. The method of claim 1, wherein the osteogenic stem cells, demineralized bone, and cortico-cancellous chips are derived from the same donor. 8. The method of claim 1, wherein the scaffold is mix of demineralized cortical bone and cortico-cancellous chips in a ratio of about 1:1, 1:2, or 1:3 demineralized cortical bone to cortico-cancellous chips. 9. The method of claim 1, wherein the osteogenic stem cells are obtained by treating the cancellous bone from a femur or tibia with collagenase and separating loosely attached cells by centrifugation. 10. The method of claim 1, wherein the osteogenic stem cells comprise osteogenic cells isolated from bone marrow harvested from iliac crest. 11. The method of claim 1, wherein the osteogenic stem cells further comprise osteogenic cells isolated from adipose tissue. 12. The method of claim 1, wherein the bone graft is frozen in a freezing media that contains DMSO. 13. A method of treatment for bone healing comprising: administering to a mammal in need thereof a previously frozen bone graft comprising a mixture of non-demineralized cortico-cancellous chips and demineralized cortical bone which form a scaffold without an additional natural or synthetic material, the cortico-cancellous chips obtained from condyles and the demineralized cortical bone obtained from cortical shafts of long bones; and osteogenic stem cells seeded on the scaffold to form the bone graft having viable cells capable of bone regeneration, wherein the osteogenic stem cells are obtained from cells cultured from a mixture of bone marrow and cells from cancellous bone treated with collagenase.

이 특허에 인용된 특허 (132)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Bone grafts including osteogenic stem cells, and methods relating to the same 원문보기

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Bone grafts including osteogenic stem cells, and methods relating to the same 원문보기

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