The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous
The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylatically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
대표청구항▼
1. A soy formulation that induces mucosal and/or systemic tolerance, wherein the soy formulation is functional in an animal model when administered orally, wherein said soy formulation comprises a heterologous protein expressed from an exogenous gene, wherein said exogenous gene codes for a protein
1. A soy formulation that induces mucosal and/or systemic tolerance, wherein the soy formulation is functional in an animal model when administered orally, wherein said soy formulation comprises a heterologous protein expressed from an exogenous gene, wherein said exogenous gene codes for a protein selected from the group consisting of acetylcholine receptor, Myelin Basic Protein, and Collagen Type II, and wherein said gene further comprises a sequence that encodes a polypeptide that acts as a targeting domain for epithelial cells, and wherein the exogenous gene is driven by a soybean beta-conglycinin 7S seed specific promoter and comprises a tobacco etch virus translational enhancer element. 2. The soy formulation of claim 1, wherein said soy formulation derives from transgenic soybeans produced by transforming soybeans using a selectable marker that is the bar gene encoding resistance to the herbicide bialophos or the EPSPS gene encoding resistance to glyphosate. 3. The soy formulation of claim 1, wherein the exogenous gene that codes for a protein is Myelin Basic Protein or acetylcholine receptor. 4. The soy formulation of claim 3, wherein said soy formulation results from a transformed soybean that is selected using a selectable marker that is the bar gene encoding resistance to the herbicide bialophos or the EPSPS gene encoding resistance to glyphosate. 5. The soy formulation of claim 3, wherein said soy formulation results from a transformed soybean that is selected using a selectable marker that is the bar gene encoding resistance to the herbicide bialophos. 6. The soy formulation of claim 3, wherein said soy formulation results from a transformed soybean that is selected using a selectable marker that is the EPSPS gene encoding resistance to glyphosate. 7. The soy formulation of claim 1, wherein the soy formulation is present in soy milk or soy powder. 8. The soy formulation of claim 7, wherein the soy formulation is present in soy milk. 9. The soy formulation of claim 7, wherein the soy formulation is present in soy powder. 10. The soy formulation of claim 2, wherein the soy formulation is present in soy milk or soy powder. 11. The soy formulation of claim 3, wherein the soy formulation is present in soy milk or soy powder. 12. The soy formulation of claim 4, wherein the soy formulation is present in soy milk or soy powder. 13. The soy formulation of claim 12, wherein the exogenous ene further comprises a terminator sequence that expresses a CaMV 35S polyadenylation sequence or a nopaline synthase polyadenylation sequence. 14. The soy formulation of claim 5, wherein the soy formulation is present in soy milk or soy powder. 15. The soy formulation of claim 14, wherein the soy formulation is present in soy milk. 16. The soy formulation of claim 14, wherein the soy formulation is present in soy powder. 17. The soy formulation of claim 6, wherein the soy formulation is present in soy milk or soy powder. 18. The soy formulation of claim 17, wherein the soy formulation is present in soy powder. 19. The soy formulation of claim 17, wherein the soy formulation is present in soy milk.
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