Methods and systems for improving the reliability of orthogonally redundant sensors
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/1455
A61B-005/145
A61B-005/1468
A61B-005/00
A61B-005/1459
A61B-005/1473
A61B-005/1495
출원번호
US-0428589
(2017-02-09)
등록번호
US-10039479
(2018-08-07)
발명자
/ 주소
Varsavsky, Andrea
Li, Xiaolong
Liu, Mike C.
Zhong, Yuxiang
Yang, Ning
출원인 / 주소
MEDTRONIC MINIMED, INC.
대리인 / 주소
Pillsbury Winthrop Shaw Pittman LLP
인용정보
피인용 횟수 :
0인용 특허 :
82
초록▼
Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via
Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
대표청구항▼
1. A method of calculating a single, fused sensor glucose (SG) value based on respective output signals of an electrochemical glucose sensor and an optical glucose sensor of an orthogonally redundant glucose sensor device, the method comprising: performing a status check on each of the electrochemic
1. A method of calculating a single, fused sensor glucose (SG) value based on respective output signals of an electrochemical glucose sensor and an optical glucose sensor of an orthogonally redundant glucose sensor device, the method comprising: performing a status check on each of the electrochemical glucose sensor and the optical glucose sensor;calculating a first reliability index for the output signal of the electrochemical sensor based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the electrochemical glucose sensor;calculating a second reliability index for the output signal of the optical sensor based on said status check for the optical sensor;calibrating the output signal of the electrochemical sensor to obtain an electrochemical sensor glucose value (echem SG);calibrating the output signal of the optical sensor to obtain an optical sensor glucose value (optical SG);calculating a first weight based on said first reliability index and calculating a weighted echem SG based on said first weight;calculating a second weight based on said second reliability index and calculating a weighted optical SG based on said second weight; andcalculating said single, fused sensor glucose value based on said weighted echem SG and said weighted optical SG. 2. The method of claim 1, wherein said status check on the optical glucose sensor is based on a value of said output signal of the optical glucose sensor. 3. The method of claim 1, wherein said status check on the optical glucose sensor is based on at least one of a previous cal ratio, a previous sensor accuracy, a sensitivity loss flag, and a dip flag for the optical glucose sensor. 4. The method of claim 3, wherein said cal ratio for the optical glucose sensor is defined as a meter glucose value divided by the optical glucose sensor's output signal. 5. The method of claim 1, wherein the second reliability index is calculated based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the optical glucose sensor. 6. The method of claim 1, wherein said first weight is a linear function of said first reliability index, said second weight is a linear function of said second reliability index, or both. 7. The method of claim 1, wherein said first weight is a non-linear function of said first reliability index, said second weight is a non-linear function of said second reliability index, or both. 8. The method of claim 1, wherein said single, fused sensor glucose value is calculated by adding said weighted echem SG to said weighted optical SG. 9. The method of claim 1, wherein the optical glucose sensor includes an assay fluorophore and a reference fluorophore, wherein the assay fluorophore generates an assay fluorescence signal and the reference fluorophore generates a reference fluorescence signal, and wherein said output signal of the optical glucose sensor is a ratio of the assay fluorescence signal to the reference fluorescence signal. 10. The method of claim 1, wherein said status check on the electrochemical glucose sensor is based on a value of said output signal of the electrochemical glucose sensor. 11. A program code storage device, comprising: a computer-readable medium; andnon-transitory computer-readable program code, stored on the computer-readable medium, the computer-readable program code having instructions, which when executed cause a microprocessor to: perform a status check on each of an electrochemical glucose sensor and an optical glucose sensor of an orthogonally redundant glucose sensor device;calculate a first reliability index for an output signal of the electrochemical sensor based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the electrochemical glucose sensor;calculate a second reliability index for an output signal of the optical sensor;calibrate the output signal of the electrochemical sensor to obtain an electrochemical sensor glucose value (echem SG);calibrate the output signal of the optical sensor to obtain an optical sensor glucose value (optical SG);calculate a first weight based on said first reliability index and generate a weighted echem SG based on said first weight;calculate a second weight based on said second reliability index and generate a weighted optical SG based on said second weight; andcalculate a single, fused sensor glucose value for the orthogonally redundant glucose sensor device based on said weighted echem SG and weighted optical SG. 12. The program code storage device of claim 11, wherein the microprocessor calculates the second reliability index based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the optical glucose sensor. 13. The program code storage device of claim 11, wherein said first weight is a linear function of said first reliability index, said second weight is a linear function of said second reliability index, or both. 14. The program code storage device of claim 11, wherein said first weight is a non-linear function of said first reliability index, said second weight is a non-linear function of said second reliability index, or both. 15. The program code storage device of claim 11, wherein the microprocessor calculates said single, fused sensor glucose value by adding said weighted echem SG to said weighted optical SG. 16. The program code storage device of claim 11, wherein the optical glucose sensor includes an assay fluorophore and a reference fluorophore, wherein the assay fluorophore generates an assay fluorescence signal and the reference fluorophore generates a reference fluorescence signal, and wherein said output signal of the optical glucose sensor is a ratio of the assay fluorescence signal to the reference fluorescence signal. 17. A method of calculating a single, fused sensor glucose (SG) value based on respective output signals of an electrochemical glucose sensor and an optical glucose sensor of an orthogonally redundant glucose sensor device, the method comprising: performing a status check on each of the electrochemical glucose sensor and the optical glucose sensor;calculating a first reliability index for the output signal of the electrochemical sensor;calculating a second reliability index for the output signal of the optical sensor based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the optical glucose sensor;calibrating the output signal of the electrochemical sensor to obtain an electrochemical sensor glucose value (echem SG);calibrating the output signal of the optical sensor to obtain an optical sensor glucose value (optical SG);calculating a first weight based on said first reliability index and calculating a weighted echem SG based on said first weight;calculating a second weight based on said second reliability index and calculating a weighted optical SG based on said second weight; andcalculating said single, fused sensor glucose value based on said weighted echem SG and said weighted optical SG. 18. The method of claim 17, wherein said status check on the electrochemical glucose sensor is based on a value of said output signal of the electrochemical glucose sensor. 19. The method of claim 17, wherein said first weight is a linear function of said first reliability index, said second weight is a linear function of said second reliability index, or both. 20. The method of claim 17, wherein said first weight is a non-linear function of said first reliability index, said second weight is a non-linear function of said second reliability index, or both. 21. The method of claim 17, wherein said single, fused sensor glucose value is calculated by adding said weighted echem SG to said weighted optical SG. 22. The method of claim 17, wherein the optical glucose sensor includes an assay fluorophore and a reference fluorophore, wherein the assay fluorophore generates an assay fluorescence signal and the reference fluorophore generates a reference fluorescence signal, and wherein said output signal of the optical glucose sensor is a ratio of the assay fluorescence signal to the reference fluorescence signal. 23. A program code storage device, comprising: a computer-readable medium; andnon-transitory computer-readable program code, stored on the computer-readable medium, the computer-readable program code having instructions, which when executed cause a microprocessor to: perform a status check on each of an electrochemical glucose sensor and an optical glucose sensor of an orthogonally redundant glucose sensor device;calculate a first reliability index for an output signal of the electrochemical sensor;calculate a second reliability index for an output signal of the optical sensor based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the optical glucose sensor;calibrate the output signal of the electrochemical sensor to obtain an electrochemical sensor glucose value (echem SG);calibrate the output signal of the optical sensor to obtain an optical sensor glucose value (optical SG);calculate a first weight based on said first reliability index and generate a weighted echem SG based on said first weight;calculate a second weight based on said second reliability index and generate a weighted optical SG based on said second weight; andcalculate a single, fused sensor glucose value for the orthogonally redundant glucose sensor device based on said weighted echem SG and weighted optical SG. 24. The program code storage device of claim 23, wherein said first weight is a linear function of said first reliability index, said second weight is a linear function of said second reliability index, or both. 25. The program code storage device of claim 23, wherein said first weight is a non-linear function of said first reliability index, said second weight is a non-linear function of said second reliability index, or both. 26. The program code storage device of claim 23, wherein the microprocessor calculates said single, fused sensor glucose value by adding said weighted echem SG to said weighted optical SG. 27. The program code storage device of claim 23, wherein the optical glucose sensor includes an assay fluorophore and a reference fluorophore, wherein the assay fluorophore generates an assay fluorescence signal and the reference fluorophore generates a reference fluorescence signal, and wherein said output signal of the optical glucose sensor is a ratio of the assay fluorescence signal to the reference fluorescence signal.
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