Methods of treating a treatment-resistant gastrointestinal spasm with an oxidized tannin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/40
A61K-036/82
A61K-031/7028
A61K-036/22
A61K-045/06
A61K-031/7034
A61K-031/352
A61K-031/7048
A61K-031/192
A61K-036/185
A61K-031/353
출원번호
US-0876361
(2018-01-22)
등록번호
US-10039784
(2018-08-07)
발명자
/ 주소
Huang, Alexander L
Wu, Gin
출원인 / 주소
LIVELEAF, INC.
대리인 / 주소
Boyer, Brian S.
인용정보
피인용 횟수 :
0인용 특허 :
80
초록▼
Methods of treating a gastrointestinal spasm in a subject are provided. The methods can include administering an effective amount of a formulation to treat the gastrointestinal spasm, the formulation having a tannin combined with a hydrogen donor in a pharmaceutically acceptable excipient as a bindi
Methods of treating a gastrointestinal spasm in a subject are provided. The methods can include administering an effective amount of a formulation to treat the gastrointestinal spasm, the formulation having a tannin combined with a hydrogen donor in a pharmaceutically acceptable excipient as a binding pair, the tannin releasing in an oxidized state from the hydrogen donor after oral administration of the formulation in the subject; wherein, the composition at least inhibits a gastrointestinal spasm in the subject when compared to a second subject in a control group in which the composition was not administered.
대표청구항▼
1. A method of treating a treatment-resistant gastrointestinal spasm in a subject, the method comprising: orally administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a binding pair in a pharmaceutically acceptable excipient; wher
1. A method of treating a treatment-resistant gastrointestinal spasm in a subject, the method comprising: orally administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a binding pair in a pharmaceutically acceptable excipient; wherein, the binding pair is created by a process comprising: selecting a water soluble tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and,oxidizing the tannin with a hydroxyl radical, the oxidizing including combining the tannin with the hydroxyl radical at a weight ratio ranging from about 1:1000 to about 10:1 to oxidize the tannin and form the binding pair having the oxidized tannin releasably bound to the hydroxyl radical;wherein,the gastrointestinal spasm is a symptom of a condition selected from the group consisting of inflammatory bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, and gastroesophageal reflux disease; and,the formulation at least inhibits the gastrointestinal spasm when compared to a second subject in a control group in which the formulation was not administered. 2. The method of claim 1, wherein the tannin is a hydrolysable tannin. 3. The method of claim 1, wherein the tannin is a water soluble condensed tannin. 4. The method of claim 1, wherein the tannin is a flavanol. 5. The method of claim 1, wherein the tannin is a catechin. 6. The method of claim 1, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 7. The method of claim 1, wherein the tannin is a gallotannin. 8. The method of claim 1, wherein the tannin is an ellagitannin. 9. The method of claim 1, wherein the tannin is a punicalagin. 10. The method of claim 2, wherein the hydrolysable tannin is a product of a water extraction of Chinese gall. 11. The method of claim 1, wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues. 12. A method of treating a treatment resistant gastrointestinal spasm in a subject, the method comprising: administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a water soluble tannin combined with a hydroxyl radical to create a binding pair prior to the administering; wherein, the binding pair is created by a process comprising:selecting a water-soluble tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;oxidizing the tannin with a hydroxyl radical, the oxidizing including combining the tannin with the hydroxyl radical at a weight ratio ranging from about 1:1000 to about 10:1 to form the binding pair having the oxidized tannin releasably bound to the hydroxyl radical;wherein,the gastrointestinal spasm is a symptom of a condition selected from the group consisting of inflammatory bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, and gastroesophageal reflux disease; and,the formulation at least inhibits the gastrointestinal spasm when compared to a second subject in a control group in which the formulation was not administered. 13. The method of claim 12, wherein the tannin is a water soluble condensed tannin. 14. The method of claim 12, wherein the tannin is a flavanol. 15. The method of claim 12, wherein the tannin is a catechin. 16. The method of claim 12, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 17. The method of claim 12, wherein the tannin is a gallotannin. 18. The method of claim 12, wherein the tannin is an ellagitannin. 19. The method of claim 12, wherein the tannin is a punicalagin. 20. The method of claim 12, including using a hydroxyl radical concentration ranging from about 0.001% to about 2.0% based on total dry weight of the composition;drying the binding pair under a vacuum; and,storing the dried binding pair for use in creating the formulation to treat irritable bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, or gastroesophageal reflux disease. 21. The method of claim 12, wherein the tannin is a hydrolysable tannin.
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