Method for formulating large diameter synthetic membrane vesicles
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/127
B01D-001/16
A61K-031/4458
B01F-003/08
B01F-005/10
B01F-007/00
A61K-009/48
A61M-011/00
B01J-013/04
B01J-013/12
A61K-031/445
B01F-003/04
B01F-015/06
출원번호
US-0786873
(2013-03-06)
등록번호
US-10045941
(2018-08-14)
발명자
/ 주소
Schutt, Ernest George
McGuire, Ronald Warren
Walters, Peter Andrew
Los, Kathleen D. A.
출원인 / 주소
Pacira Pharmaceuticals, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
173
초록▼
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
대표청구항▼
1. A process for preparing droplets using an atomizing nozzle apparatus, wherein the apparatus comprises: a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice; a first fluid contacting
1. A process for preparing droplets using an atomizing nozzle apparatus, wherein the apparatus comprises: a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice; a first fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid conduit and the at least one exit orifice of the second fluid conduit, wherein the second fluid conduit annularly surrounds a portion of the first fluid conduit, wherein the first fluid contacting chamber conically tapers from the top of the first fluid contacting chamber to the bottom of the first fluid contacting chamber;a second fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid contacting chamber and the at least one exit orifice of the third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the first fluid contacting chamber and wherein the diameter of the second fluid contacting chamber conically tapers from its top to its bottom, wherein the first and second fluid contacting chambers are hydraulic extrusion cones; andthe fourth fluid conduit, wherein the fourth fluid conduit annularly surrounds a portion of the second fluid contacting chamber,wherein the process for preparing droplets comprises:applying a first liquid to the first fluid conduit;applying a second liquid to the second fluid conduit;applying a third liquid to the third fluid conduit; andapplying a gas to the fourth fluid conduit,wherein the gas exiting the fourth fluid conduit exit orifice impinges the liquid exiting the at least one exit orifice of the second fluid contacting chamber, providing atomized droplets, wherein the droplets have an average diameter from about 100 nm to about 100 μM. 2. The process of claim 1, wherein: the first liquid is an emulsion comprised of: i) a discontinuous first aqueous phase; andii) a continuous first organic phase comprising a first organic solvent;the second liquid is a second organic phase;the third liquid is a second aqueous phase. 3. The process of claim 1, wherein: the first liquid is an emulsion comprised of: i) a discontinuous first aqueous phase; andii) a continuous first organic phase comprising a first organic solvent;the second liquid is a second aqueous phase;the third liquid is a second organic phase. 4. The process of claim 2, wherein the first organic solvent is chloroform or methylene chloride. 5. The process of claim 2, wherein the first organic phase further comprises at least one amphipathic lipid and at least one neutral lipid. 6. The process of claim 1, wherein the second liquid forms a sheath around the first liquid, the first liquid forming a first liquid core. 7. The process of claim 6, wherein the second liquid sheath comprises a composition that is different from a composition of the first organic phase. 8. The process of claim 6, wherein the first fluid contacting chamber decreases the diameter of the first liquid core and the second liquid. 9. The process of claim 6, wherein the diameter of the second fluid contacting chamber conically tapers from its top to its bottom and the third liquid is constricted by the second fluid contacting chamber to create a concentric annular sheath around the first liquid core and the second liquid sheath. 10. The process of claim 2, wherein the second organic phase comprises a charged lipid solution. 11. The process of claim 2, wherein the atomized droplets comprise an outer layer and an internal membrane, the outer layer comprising a charged lipid and the internal membrane comprising a lipid. 12. The process of claim 2, wherein the first organic phase further comprises a first lipid and the second organic phase comprises a second lipid and a second organic solvent. 13. The process of claim 12, wherein the second lipid is the same type of lipid as the first lipid. 14. The process of claim 12, wherein the second lipid is a different type of lipid than the first lipid. 15. The process of claim 12, wherein the second organic solvent is the same type of solvent as the first organic solvent. 16. The process of claim 12, wherein the second organic solvent is a different type of solvent than the first organic solvent. 17. The process of claim 2, wherein the second organic phase comprises a polymer and an organic solvent. 18. The process of claim 2, wherein the second organic phase comprises a polymer. 19. The process of claim 1, wherein the third liquid is a buffer solution. 20. The process of claim 1, wherein the first fluid travels at a first volumetric flow rate through the first fluid conduit, the second fluid travels at a second volumetric flow rate through the second fluid conduit, and the third fluid travels at a third volumetric flow rate through the third fluid conduit. 21. The process of claim 20, wherein each of the first volumetric flow rate, second volumetric flow rate, and third volumetric flow rate is between 2 mL/minute and 1,000 mL/minute. 22. The process of claim 20, wherein each of the first volumetric flow rate, second volumetric flow rate, and third volumetric flow rate is between 10 mL/minute and 500 mL/minute. 23. The process of claim 20, wherein each of the first volumetric flow rate, second volumetric flow rate, and third volumetric flow rate is between 10 mL/minute and 100 mL/minute. 24. The process of claim 20, wherein each of the first volumetric flow rate, second volumetric flow rate, and third volumetric flow rate is between 50 mL/minute and 100 mL/minute. 25. The process of claim 1, wherein: the first liquid is an aqueous phase comprising an active agent;the second liquid is an organic phase comprising a lipid solution; andthe third liquid is a buffer solution. 26. The process of claim 1, wherein: the first liquid is a first aqueous phase;the second liquid is an organic phase comprising phospholipids, a polymer, or a combination of phospholipids and a polymer in an organic solvent; andthe third liquid is a second aqueous phase.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (173)
Grantham LeRoy F. (Calabasas CA) Gehri Dennis C. (Granada Hills CA) Katz Bruno (Encino CA), Absorption of sulfur oxides from flue gas.
Salpekar Anil M. (Creve Coeur MO) Johnson John (Collinsville IL), Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets forme.
Hidekazu Yamazaki JP; Tadahiro Tsujimoto JP; Yukihiro Katai JP, Apparatus containing cooling and warming devices for the preparation of a polymer solution.
Muschelknautz Edgar (Leverkusen DEX) Herold Heiko (Dormagen DEX) Brunner Kunz (Cologne DEX) Horstmann Walter (Schildgen DEX), Apparatus for the mechanical separation of solids from drying gas in spray driers.
Eck Herbert (Burghausen DEX) Roth Michael (Burghausen DEX), Aqueous redispersible powders which contain a water-soluble polymer and at least one organic silicon compound and a proc.
Allen Thomas E. (4045 N. Garnett Tulsa OK 74116), Automatic cement mixing and density simulator and control system and equipment for oil well cementing.
Meschke Debra J. (Valley Cottage NY) Hoy Kenneth L. (St. Albans WV) Theiling ; Jr. Louis F. (Charleston WV), Ceramic composition and process for use thereof.
Kim In (354-7 Myunmok-Dong ; Dongdaemoon-Ku Seoul KRX) Kim Seo (354-7 Myunmok-Dong ; Dongdaemoon-Ku Seoul KRX), Colloid-active synthetic detergent and process for its manufacture.
Graves ; Jr. George A. (Bellbrook OH) McCullum Dale E. (Vandalia OH) Goodrich Steven M. (Dayton OH), Controlled pore size ceramics particularly for orthopaedic and dental applications.
Lee Fei P. (Novi MI) Guzowski Mike (Canton MI), Fuel injector assembly with first and second fuel injectors and inner, outer, and intermediate air discharge chambers.
Zwiercan Gary A. (Knutsford NJ GB2) Lacourse Norman L. (Plainsboro NJ) Lenchin Julianne M. (Cranbury NJ), Imitation cheese products containing high amylose starch as total caseinate replacement.
Bolotin Elijah M. ; Grant Gilbert J. ; Barenholz Yechezkel,ILX ; Turndorf Herman ; Piskoun Boris, Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient.
Damgaard-Iversen Jorgen (Birkerod DK) Gude Klaus Erik (Vedbaek DK) Hansen Ove Emil (Vaerlose DK) Lund Bjorn (Frederiksberg DK) Petersen Mogens (Lyngby DK), Method and apparatus for evaporating liquid.
Lundquist ; Jr. Joseph Theodore (Ellicott City MD) Veltman Preston Leonard (Severna Park MD) Woodruff Edward Theodore (Woodbine MD), Method for drying fructose solutions.
Arndt Peter J. (Seeheim-Jugenheim DEX) Wenzel Franz (Darmstadt DEX) Mller Manfred (Rossdorf DEX) Schlosser Fritz (Darmstadt DEX), Method for isolating vinyl salt compounds from aqueous solutions.
Katcher Jay H. (Cranbury NJ) Mabon John T. (Andover MA) Matherly Jennifer W. (Cherry Hill NJ) McCarty Lawrence T. (Dover DE) Schara Robert E. (Princeton Junction NJ), Method for pregelatinized, spray-dried starch agglomerates.
Kalka Josef (Herten DT) Winter Hermann (Marl DT) Smolinski Manfred (Marl DT) Wolf Hans-Georg (Marl DT), Method for preparing synthetic powders based on polyvinyl chloride or vinyl chloride copolymers containing emulsifiers.
Netting David I. (Springfield PA) Hertzenberg Elliot P. (Wilmington DE), Method of preparing modified hollow, largely spherical particles by spray drying.
Swarr Thomas E. (South Windsor CT) Nickols Richard C. (East Hartford CT) Krasij Myron (Avon CT), Method of preparing thin porous sheets of ceramic material.
Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
Sauer Heinz (Odenthal DEX) Dallmeyer Hermann (Odenthal DEX) Zarnack Uwe J. (Brunsbuettel DEX) Keggenhoff Berthold (Krefeld DEX) Weber Bernd (Krefeld DEX), Mixer for mixing at least two free-flowing substances, especially those which react during mixing.
Cassani Giovanni Rodolfo (Pavia ITX) Lani Marina Barbara (Lesmo ITX), Mobile-module plant for the development and the production of biotechnological products on a pilot scale.
Kim Sinil ; Howell Stephen B., Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride.
Kim Sinil ; Howell Stephen B., Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride.
Salpekar Anil M. (Creve Coeur MO) Freebersyser Steven R. (Florissant MO) Robinson Douglas A. (Creve Coeur MO), N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same.
Veltman Preston L. (212 Old Country Rd. Severna Park MD 21146) Hansen Ove (6560 Walnut Grove Columbia MD 21045), Particulate fuel components for solid propellant systems.
Seeger Hanspeter (Dottingen DEX), Process and apparatus for the separation of emulsions or of solids from a suspension of solids and a liquid by means of.
Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI) Wisniach Joseph T. (Riverview MI), Process for lubricating water-soluble vitamin powders.
Kaczur Jerry J. (Cleveland TN) Deininger J. Paul (Los Alamos NM) Carpenter Larry D. (Cleveland TN), Process for making selected doped barium and strontium hexaferrite particles.
Yamazaki Hiroshi (Nepean CAX) Modler Howard W. (Kemptville CAX) Jones John D. (Ottawa CAX) Elliot James I. (Ottawa CAX), Process for preparing flour from Jerusalem artichoke tubers.
Schara Robert E. (Princeton Junction NJ) Katcher Jay H. (Cranbury NJ), Process for preparing modified, pregelatinized dent cornstarch and product thereof.
Moller Jens C. T. (5245 Hayledge Court Columbia MD 21045) Hansen Ove E. (Skovgards Alle 261 3500 Ll. Vaerlose DK), Process for preparing paraformaldehyde.
Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI) Schmidt Douglass N. (Grosse Ile MI), Process for preparing spray dried acetaminophen powder and the powder prepared thereby.
Schmidt Douglass N. (Grosse Ile MI) Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI), Process for preparing spray-dried powders containing a water-soluble vitamin and powders prepared thereby.
Subramaniam Anandaraman (Syracuse NY) Ozogar Robert M. (Mattydale NY) Bergsbaken Carlton K. (Syracuse NY), Process for preparing “non-bitter”enzyme modified cheese flavoring material and spray dried product.
Kalka Josef (Herten DEX) Winter Hermann (Marl DEX) Kania Alfred (Marl DEX), Process for production of polymers of vinyl chloride for paste preparation using spray-drying.
Seiter Wolfgang (Neuss DEX) Wegener Ingo (Duesseldorf DEX) Reuter Herbert (Hilden DEX), Process for the production of a spray-dried nonionic washing aid.
Brenner Joseph (Middletown NY) Henderson Gary H. (Middletown NY) Bergensten Robert W. (Kerhonkson NY), Process of encapsulating an oil and product produced thereby.
Hensler Paul L. (Lawrence KS) Kelso Frederick J. (Trenton NJ) Wolfe Gary E. (Trenton NJ) Zeh Peter H. (Fremont CA), Production of Phase II sodium tripolyphosphate.
Horn Hans Christoph,DEX ; Kumberger Otto,DEX ; Millies Marco,DEX ; Neth Norbert,DEX ; Popel Wolfgang Jurgen,DEX ; Rieker Christopher William,DEX ; Sprague Michael Jolyon,DEX ; Stroezel Manfred,DEX, Production of solids by precipitation.
Kowalski Werner (Weilerswist DEX) Haas Hans (Swisttal DEX) Dahmen Theo (Brhl DEX) Erpenbach Markus (Cologne DEX), Spheroidal alkali metal polyphosphates of low apparent density, and process for making them.
Kowalski Werner (Weilerswist DEX) Haas Hans (Swisttal DEX) Dahmen Theo (Brhl DEX) Erpenbach Markus (Cologne DEX), Spheroidal alkali metal polyphosphates of low apparent density, and process for making them.
Kirkpatrick Paul A. (Jackson NJ) Schulman Marvin (Howell NJ) Lehmann Douglas M. (Howell NJ) Hegadorn Joseph L. (Ridgewood NJ), Three-fluid atomizing nozzle and method of utilization thereof.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.