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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0796163 (2017-10-27) |
등록번호 | US-10052051 (2018-08-21) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 566 |
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) pol
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
1. An implantable continuous analyte sensor for measuring an analyte concentration, comprising: a working electrode configured to generate a signal indicative of an analyte concentration;a membrane disposed over the working electrode, the membrane comprising: a first domain configured to control a f
1. An implantable continuous analyte sensor for measuring an analyte concentration, comprising: a working electrode configured to generate a signal indicative of an analyte concentration;a membrane disposed over the working electrode, the membrane comprising: a first domain configured to control a flux of an analyte therethrough, wherein the first domain comprises a blend comprising a first polymer and second polymer, wherein the first polymer is a polymer selected from the group consisting of polyurethane, polyurea, polyurethaneurea, and a silicone-containing polymer, wherein the second polymer is a hydrophilic comb-copolymer; anda second domain comprising an enzyme configured to react with an analyte, wherein at least a portion of the second domain is disposed between the first domain and the working electrode; andsensor electronics operatively connected to the working electrode, wherein the sensor electronics are configured to process the generated signal to produce a glucose value. 2. The implantable continuous analyte sensor of claim 1, wherein the first polymer is a silicone-containing polyurethane. 3. The implantable continuous analyte sensor of claim 1, wherein the analyte is glucose. 4. The implantable continuous analyte sensor of claim 1, wherein the sensor is configured to be transcutaneously implanted. 5. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a poly(ethylene oxide) (PEO) segment. 6. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a poly(propylene oxide) (PPO) segment. 7. The implantable continuous analyte sensor of claim 1, wherein the second polymer has a molecular weight from 1,000 g/mol to 15,000 g/mol. 8. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a hydrophilic domain and a hydrophobic domain, wherein the hydrophobic domain has a molecular weight from 500 g/mol to 8,000 g/mol.
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