Methods, devices and systems for improving sleep (including reducing sleep onset and maintenance of sleep duration), enhancing, or increasing sleep, including (but not limited to) treating sleeping disorders such as insomnia.
대표청구항▼
1. A thermal system for enhancing a subject's sleep, the system comprising: a thermal regulator unit having a housing, the thermal regulator unit configured to control the temperature of a thermal transfer fluid;a clock coupled with the thermal regulator unit;a display coupled with the clock and the
1. A thermal system for enhancing a subject's sleep, the system comprising: a thermal regulator unit having a housing, the thermal regulator unit configured to control the temperature of a thermal transfer fluid;a clock coupled with the thermal regulator unit;a display coupled with the clock and the thermal regulator unit;a thermal applicator configured to be worn against the subject's forehead over the subject's prefrontal and frontal cortex, wherein the thermal applicator is configured to pass thermal transfer fluid from the thermal regulator unit;a controller within the thermal regulator unit configured to regulate the temperature of the thermal transfer fluid based on one or more thermal control profiles to modulate the subject's sleep by controlling a temperature of the thermal applicator;a headgear to maintain the thermal applicator in contact with the region of the subject's head over the prefrontal and frontal cortex; anda cartridge containing thermal transfer fluid in a reservoir and configured to insert into a top of the thermal regulator unit, the cartridge having a valve on a bottom of the cartridge and a vent on a top of the cartridge, wherein the vent comprises a material that is air-permeable but not liquid-permeable and is configured to allow air into the reservoir. 2. The system of claim 1, further wherein the controller is configured to receive input from the clock and to modify the temperature of the thermal transfer fluid at a predetermined wakeup time to wake the subject. 3. The system of claim 1, wherein the controller is configured to maintain the temperature of the thermal transfer fluid so that the temperature of the thermal applicator is at a target temperature selected from the range consisting of: about 10 degrees C. to about 41 degrees C. 4. The system of claim 1, wherein the thermal regulator unit comprises one or more of: a Peltier device, a resistive heater, and a fan. 5. The system of claim 1, wherein the thermal applicator is adapted to thermally regulate only the region of the subject's head over the prefrontal and frontal cortex, but not other regions of the subject's head and face including the eye orbits. 6. The system of claim 1, wherein the controller comprises a plurality of thermal control profiles configured to cause the controller to regulate the temperature of the thermal transfer fluid. 7. The system of claim 1, wherein the thermal regulator unit comprises a thermal electric module configured to heat, cool, or heat and cool the thermal transfer fluid. 8. The system of claim 1, further comprising a fluid conduit connecting the thermal regulator unit and the thermal applicator, the fluid conduit configured to transfer thermal transfer fluid between the thermal regulator unit and the thermal applicator. 9. The system of claim 1, further comprising a fluid level detector within the thermal regulator unit configured to monitor the level of thermal transfer fluid within the system. 10. The system of claim 1, further comprising a control in communication with the thermal regulator unit configured to allow the subject to select the one or more thermal control profiles. 11. The system of claim 1, wherein the headgear is configured to maintain the thermal applicator in contact with just the region of the subject's head over the prefrontal and frontal cortex. 12. The system of claim 1, wherein the thermal regulator unit comprises a second reservoir for thermal transfer fluid within an internal plumbing of the thermal regulator that is configured to be thermally regulated by a thermal electric module of the thermal regulator unit, and a second valve configured to transfer fluid between the reservoir of the cartridge and the second reservoir to maintain a level of thermal transfer fluid within the second reservoir. 13. The system of claim 1, wherein the display comprises a dead front display that is visible through the housing of the thermal regulator unit when illuminated. 14. A thermal system for enhancing a subject's sleep, the system comprising: a thermal regulator unit having a housing, the thermal regulator unit configured to control the temperature of a thermal transfer fluid;a clock coupled with the thermal regulator unit;a display coupled with clock and the thermal regulator unit; a user input configured to allow the user to select a wakeup time;a thermal applicator configured to be worn against a subject's forehead over the subject's prefrontal and frontal cortex, wherein the thermal applicator is configured to pass thermal transfer fluid from the thermal regulator unit;a controller within the thermal regulator unit configured to regulate the temperature of the thermal transfer fluid based on one or more thermal control profiles to modulate the subject's sleep by controlling a temperature of the thermal applicator, wherein the controller is configured to modify the temperature of the thermal transfer fluid at the wakeup time;a headgear to maintain the thermal applicator in contact with the region of the subject's head over the prefrontal and frontal cortex; anda cartridge containing thermal transfer fluid in a reservoir configured to insert into a top of the thermal regulator unit, the cartridge having a valve on a bottom of the cartridge and a vent on a top of the cartridge, wherein the vent comprises a material that is air-permeable but not liquid-permeable and is configured to allow air into the reservoir. 15. The system of claim 14, wherein the thermal applicator is adapted to thermally regulate only the region of the subject's head over the prefrontal and frontal cortex, but not other regions of the subject's head and face including the eye orbits. 16. The system of claim 14, wherein the controller comprises a plurality of thermal control profiles configured to cause the controller to regulate the temperature of the thermal transfer fluid. 17. The system of claim 14, wherein the thermal regulator unit comprises a thermal electric module configured to heat, cool, or heat and cool the thermal transfer fluid. 18. The system of claim 14, further comprising an insulated fluid conduit connecting the thermal regulator unit and the thermal applicator, the fluid conduit configured to transfer thermal transfer fluid between the thermal regulator unit and the thermal applicator. 19. The system of claim 14, further comprising a fluid level detector within the thermal regulator unit configured to monitor the level of thermal transfer fluid within the system. 20. The system of claim 14, further comprising a control in communication with the thermal regulator unit configured to allow the subject to select the one or more thermal control profiles. 21. The system of claim 14, wherein the headgear is configured to maintain the thermal applicator in contact with just the region of the subject's head over the prefrontal and frontal cortex. 22. The system of claim 14, wherein the thermal regulator unit comprises a second reservoir for thermal transfer fluid within an internal plumbing of the thermal regulator that is configured to be thermally regulated by a thermal electric module of the thermal regulator unit, and a second valve configured to transfer fluid between the reservoir of the cartridge and the second reservoir to maintain a level of thermal transfer fluid within the second reservoir. 23. The system of claim 14, wherein the thermal regulator unit comprises one or more of: a Peltier device, a resistive heater, and a fan. 24. A thermal system for enhancing a subject's sleep, the system comprising: a thermal regulator unit having a housing, the thermal regulator unit configured to control the temperature of a thermal transfer fluid;a thermal electric module within the thermal regulator unit configured to heat, cool, or heat and cool the thermal transfer fluid;a first reservoir of thermal transfer fluid within an internal plumbing of the thermal regulator, wherein the first reservoir is configured to be thermally regulated by the thermal electric module;a second reservoir of thermal transfer fluid that is not thermally regulated by the thermal electric module, wherein the second reservoir comprises a removable cartridge configured to insert into a top of the thermal regulator unit, the cartridge having a first valve on a bottom of the cartridge and a vent on a top of the cartridge, wherein the vent comprises a material that is air-permeable but not liquid-permeable and is configured to allow air into the second reservoir;a second valve configured to transfer fluid between the first reservoir and the second reservoir to maintain a level of thermal transfer fluid within the first reservoir;a thermal applicator configured to be worn against a subject's forehead over the subject's prefrontal and frontal cortex, wherein the thermal applicator is configured to pass thermal transfer fluid from the thermal regulator unit;a controller within the thermal regulator unit configured to regulate the temperature of the thermal transfer fluid based on one or more thermal control profiles to modulate the subject's sleep by controlling a temperature of the thermal applicator, wherein the controller is configured to modify the temperature of the thermal transfer fluid at the wakeup time to wake the subject; anda headgear to maintain the thermal applicator in contact with the region of the subject's head over the prefrontal and frontal cortex. 25. The system of claim 24, wherein the controller is configured to maintain the temperature of the thermal transfer fluid in the first reservoir so that the temperature of the thermal applicator is at a target temperature selected from the range consisting of: about 10 degrees C. to about 41 degrees C. 26. The system of claim 24, further wherein the controller is configured to modify the temperature of the thermal transfer fluid at a predetermined wakeup time. 27. The system of claim 24, further comprising a clock having a clock display. 28. The system of claim 24, wherein the thermal applicator is adapted to thermally regulate only the region of the subject's head over the prefrontal and frontal cortex, but not other regions of the subject's head and face including the eye orbits. 29. The system of claim 24, wherein the controller comprises a plurality of thermal control profiles configured to cause the controller to regulate the temperature of the thermal transfer fluid. 30. The system of claim 24, wherein the thermal regulator unit comprises one or more of: a Peltier device, a resistive heater, and a fan. 31. The system of claim 24, further comprising a fluid conduit connecting the thermal regulator unit and the thermal applicator, the fluid conduit configured to transfer thermal transfer fluid between the first reservoir and the thermal applicator. 32. The system of claim 24, further comprising a fluid level detector within the first reservoir configured to monitor the level of thermal transfer fluid within the first reservoir. 33. The system of claim 24, further comprising a control in communication with the thermal regulator unit configured to allow the subject to select the one or more thermal control profiles. 34. The system of claim 24, wherein the headgear is configured to maintain the thermal applicator in contact with just the region of the subject's head over the prefrontal and frontal cortex.
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