Provided herein are composite nanoparticles, methods of making composite nanoparticles and methods of using composite nanoparticles to treat or ameliorate various diseases, such as, for example, cancer.
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1. A composite nanoparticle comprising subunit nanoparticles of between about 10 nm and about 20 nm diameter which includes at least one compound of Formula (I): or salts, hydrates or solvates thereof wherein: R1 is hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, —SiR6R7R8,
1. A composite nanoparticle comprising subunit nanoparticles of between about 10 nm and about 20 nm diameter which includes at least one compound of Formula (I): or salts, hydrates or solvates thereof wherein: R1 is hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, —SiR6R7R8, alkyl substituted with one or more SiR6R7R8, —CH═NOR13 or optionally R1 and R2 together with the atom to which they are connected form a 5, 6 or 7 membered cycloalkyl or cycloheteroalkyl ring or substituted cycloalkyl or cycloheteroalkyl ring;R2 is hydrogen, alkyl, substituted alkyl, —NO2 or −NH2;R3 is hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, or —OR9 or optionally R3 and R4 together with the atom to which they are connected form a 5, 6 or 7 membered cycloalkyl or cycloheteroalkyl ring or substituted cycloalkyl or cycloheteroalkyl ring;R4 is hydrogen or halogen;R5 is alkyl, aryl, arylalkyl, acyl or -(L)n-P;R6, R7 or R8 are independently alkyl or arylalkyl;R9 is hydrogen, alkyl, substituted alkyl, —C(O)R10—C(O)OR10, —C(O)NR11R12, —P or -(L)n-P;R10 is alkyl, substituted alkyl, arylalkyl, substituted alkyl, heteroalkyl or substituted heteroalkyl;R11, R12 and R13 are independently alkyl, substituted alkyl, arylalkyl, substituted alkyl, heteroalkyl or substituted heteroalkyl or optionally R12 and R13 together with the atom to which they are connected form a 5, 6 or 7 membered cycloheteroalkyl ring or substituted cycloheteroalkyl ring;L is a linker;P is a polymer; andn is 0 or 1, wherein the composite nanoparticle has a diameter of between about 60 nm and about 400 nm; and wherein the particle is coated with a hydrophilic layer and a recognition element. 2. The composite nanoparticle of claim 1, wherein the diameter is between about 100 nm and about 300 nm. 3. The method of claim 1, wherein the hydrophilic layer is PEG, polyvinylpyrrolidine, albumin, poloxamers, polysorbate, vitamin E TPGS, polysaccharides, copolymers or combinations thereof. 4. The composite nanoparticle of claim 1, wherein the recognition element is an antibody, a ligand, a carbohydrate or a nucleic acid. 5. The composite nanoparticle of claim 4, wherein the ligand is folate, biotin, tarquidar, RGD peptide or RGD peptidomimetic. 6. The composite nanoparticle of claim 1, wherein the subunit nanoparticles are crosslinked. 7. The composite nanoparticle of claim 1, wherein the composite nanoparticle decomposes below about pH 6.4. 8. The composite nanoparticle of claim 1, wherein the subunit nanoparticles comprise dendrimers or block polymers. 9. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (II): 10. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (III): 11. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (IV): 12. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (V): 13. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (VI): 14. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (VII): 15. The compound of claim 14, wherein R5 is —C(O)n-pentyl. 16. The compound of claim 14, wherein R5 is C10-C20 acyl. 17. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (VIII): 18. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (IX): 19. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (X): 20. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (XI): 21. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (XII): 22. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (XIII): 23. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula (XIV): 24. The composite nanoparticle of claim 1, wherein the compound of claim 1 has structural Formula:
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