초록

Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.

대표청구항 ▼

1. A method for treating a patient with a cancerous tumor, comprising: intratumorally administering to the patient a composition comprising a pharmaceutically effective amount of oxygen scavenging membrane fragments, wherein the oxygen scavenging membrane fragments are derived from the cytoplasmic m

1. A method for treating a patient with a cancerous tumor, comprising: intratumorally administering to the patient a composition comprising a pharmaceutically effective amount of oxygen scavenging membrane fragments, wherein the oxygen scavenging membrane fragments are derived from the cytoplasmic membranes of Escherichia coli, Salmonella typhimurium, Gluconobacter oxydans, Pseudomonas aeruginosa, or Acetobacter; intratumorally administering to the patient a pharmaceutically effective amount of anaerobe bacteria; and,wherein the composition contains the oxygen scavenging membrane fragments in an amount from 0.1 unit per milliliter to 100 units per milliliter. 2. The method of claim 1, wherein the composition further comprises a hydrogen donating substance. 3. The method of claim 2, wherein the hydrogen donating substance is lactic acid, succinic acid, alpha-glycerol phosphate, formic acid, malic acid, or a salt thereof. 4. The method of claim 1, wherein the composition is in the form of an injection, solution, suspension, or emulsion. 5. The method of claim 1, wherein the composition contains the oxygen scavenging membrane fragments in an amount from 1 unit per milliliter to 10 units per milliliter. 6. The method of claim 1, wherein the tumor is a breast, cervical, colon, liver, lung, ovarian, pancreatic, prostate, brain, or bone cancer tumor. 7. The method of claim 1, wherein the composition is administered in combination with chemotherapy, immunotherapy, radiation therapy, drug therapy, or cell transplantation. 8. The method of claim 1, wherein the administration of the composition creates localized hypoxia. 9. The method of claim 1, wherein the anaerobe bacteria are present in the composition in an amount of about 106 to about 108 CFU/mL. 10. The method of claim 1, wherein the anaerobe bacteria is Bacteroides fragilis, Bifidobacterium adolescentis, Clostridium perfringens, Fusobacterium nucleatum, Porphyromonas levii, Peptostreptococcus anaerobius, Prevotella melaninogenica, or a combination thereof. 11. The method of claim 1, wherein the anaerobe bacteria is Bacteroides fragilis, Bifidobacterium adolescentis, Clostridium perfringens, Fusobacterium nucleatum, Porphyromonas levii, Peptostreptococcus anaerobius, Prevotella melaninogenica, or a combination thereof. 12. The method of claim 1, wherein the composition further comprises an anti-angiogenic agent. 13. A method for treating a tumor, comprising: intratumorally administering a composition comprising a pharmaceutically effective amount of oxygen scavenging membrane fragments, wherein the oxygen scavenging membrane fragments are derived from the cytoplasmic membranes of Escherichia coli, Salmonella typhimurium, Gluconobacter oxydons, Pseudomonas aeruginosa, or Acetobacter; intratumorally administering a pharmaceutically effective amount of anaerobe bacteria, wherein the anaerobe bacteria is Bacteroides fragilis, Bifidobacterium adolescentis, Clostridium perfringens, Fusobacterium nucleatum, Porphyromonas levii, Peptostreptococcus anaerobius, Prevotella melaninogenica, or a combination thereof; and,wherein the composition contains the oxygen scavenging membrane fragments in an amount from 0.1 unit per milliliter to 100 units per milliliter. 14. A therapeutic composition for treating a cancer tumor, comprising: a pharmaceutically effective amount of oxygen scavenging membrane fragments and a pharmaceutically effective amount of anaerobe bacteria,wherein the oxygen scavenging membrane fragments are derived from the cytoplasmic membranes of Escherichia coli, Salmonella typhimurium, Gluconobacter oxydans, Pseudomonas aeruginoso, or Acetobacter; wherein the anaerobe bacteria is Bacteroides fragilis, Bifidobacterium adolescentis, Clostridium perfringens, Fusobacterium nucleatum, Porphyromonas levii, Peptostreptococcus anaerobius, Prevotella melaninogenica, or a combination thereof; and, wherein the composition contains the oxygen scavenging membrane fragments in an amount from 0.1 unit per milliliter to 100 units per milliliter. 15. The composition of claim 14, wherein the composition further comprises a hydrogen donating substance. 16. The composition of claim 15, wherein the hydrogen donating substance is lactic acid, succinic acid, alpha-glycerol phosphate, formic acid, malic acid, or a salt thereof. 17. The composition of claim 14, wherein the composition contains the oxygen scavenging membrane fragments in an amount from 1 unit per milliliter to 10 units per milliliter. 18. The composition of claim 14, further comprising an anti-angiogenic agent.