Protease modulating wound interface layer for use with negative pressure wound therapy
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/00
A61L-015/42
A61L-015/32
A61L-015/28
A61L-015/22
A61H-009/00
출원번호
US-0819988
(2015-08-06)
등록번호
US-10076587
(2018-09-18)
발명자
/ 주소
Locke, Christopher Brian
Robinson, Timothy Mark
Cullen, Breda Mary
출원인 / 주소
KCI Licensing, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
92
초록▼
Systems, methods, and apparatuses for modulating proteases including matrix metalloproteinase (MMP), elastase, and bacterial protease in a negative pressure therapy system are described. A mesh having a sacrificial substrate is included. The sacrificial substrate includes a plurality of collagen fib
Systems, methods, and apparatuses for modulating proteases including matrix metalloproteinase (MMP), elastase, and bacterial protease in a negative pressure therapy system are described. A mesh having a sacrificial substrate is included. The sacrificial substrate includes a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings. The openings of the plurality of openings have an average area between about 0.5 mm2 and about 20 mm2 to permit the flow of negative pressure through the mesh. The sacrificial substrate can also include oxidized regenerated cellulose.
대표청구항▼
1. A negative-pressure therapy system for modulating proteases in a tissue site, the system comprising: a modulating layer including a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings;
1. A negative-pressure therapy system for modulating proteases in a tissue site, the system comprising: a modulating layer including a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings;wherein the openings of the plurality of openings have an average effective diameter between about 0.5 mm and about 5 mm to permit the flow of negative pressure through the network;a manifold configured to be positioned adjacent the network;a cover configured to be positioned over the manifold and the network and coupled to tissue adjacent the tissue site to form a sealed space; anda negative-pressure source configured to be fluidly coupled to the manifold to provide negative pressure to the sealed space through the manifold and the network. 2. The method of claim 1, wherein the openings have an average area between about 0.2 mm2 and about 20.0 mm2. 3. The system of claim 1, wherein the openings are generally circular in shape and have an average diameter between about 1 mm and about 2.5 mm. 4. The system of claim 1, wherein the collagen fibers have a diameter of less than about 1 millimeter. 5. The system of claim 1, wherein the collagen fibers have a diameter of between about 1 micron and 50 microns. 6. The system of claim 1, wherein the network has a thickness between about 5 microns and about 2 millimeters. 7. The system of claim 1, wherein the network has a thickness of about 25 microns. 8. The system of claim 1, wherein the collagen fibers have a collagen content between about 10% and about 50% of the total material of the collagen fiber. 9. The system of claim 1, wherein the collagen fibers comprise a string of collagen elements. 10. The system of claim 1, wherein the supporting material comprises supporting fibers. 11. The system of claim 10, wherein the supporting fibers are twisted with the plurality of collagen fibers. 12. The system of claim 10, wherein the supporting fibers support separate collagen elements to form the plurality of collagen fibers. 13. The system of claim 12, further comprising a plurality of supporting fibers operatively coupled to the plurality of collagen fibers. 14. The system of claim 12, wherein the plurality of supporting fibers and the plurality of collagen fibers are woven together. 15. The system of claim 12, wherein the supporting fibers are water soluble. 16. The system of claim 12, wherein the supporting fibers are biodegradable. 17. The system of claim 12, wherein the plurality of collagen fibers and the plurality of supporting fibers have a collagen content between about 10% and about 50% of the modulating layer. 18. The system of claim 12, wherein the collagen fibers and supporting fibers are non-woven. 19. The system of claim 1, wherein the collagen fibers comprise: staple fibers formed from collagen; andstaple fibers formed from the supporting material;wherein the staple fibers formed of collagen and the staple fibers formed of the supporting material are twisted together to form the collagen fibers. 20. The system of claim 19, wherein the supporting material comprises one or more selected from a group consisting of: polyethylene oxide, alginate, polylactic acid, polyvinyl alcohol, polycapralactones, and polyamides. 21. The system of claim 19, wherein a length of the staple fibers formed from collagen is between about 4 mm and about 6 mm. 22. The system of claim 19, wherein the collagen fibers have a collagen content between about 10% and about 50% of the total material of the collagen fiber. 23. The system of claim 1, further comprising a plurality of oxidized regenerated cellulose fibers intersecting the collagen fibers to form the network having the plurality of openings. 24. The system of claim 23, wherein about 45% of the network comprises oxidized regenerated cellulose fibers. 25. The system of claim 23, wherein about 55% of the network comprises collagen fibers.
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