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Methods are described for packaging a foldable container including covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical

Methods are described for packaging a foldable container including covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials enclosing at least one pharmaceutical agent, the interconnected monodose pharmaceutical vials connected to one another by one or more articulating joints sufficiently flexible to form a folded configuration of the multi-monodose container; exerting a force on at least one of the monodose pharmaceutical vials; bending the one or more articulating joints to form the folded configuration of the multi-monodose container in response to the exerted force; and sealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container.

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1. A method of packaging a foldable container, comprising: covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials p

1. A method of packaging a foldable container, comprising: covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials polygonal in horizontal cross-section and enclosing a dose of at least one pharmaceutical agent; andone or more articulating joints connecting each of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials to at least one adjacent monodose pharmaceutical vial, the one or more articulating joints sufficiently flexible to reversibly mate a planar outer surface of each of the monodose pharmaceutical vials with a planar outer surface of the at least one adjacent monodose pharmaceutical vial to form a folded configuration of the multi-monodose container, wherein the expanded configuration of the multi-monodose container has a first rectangular packing cross-sectional area;exerting a force on at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials, the exerted force directed toward the at least one adjacent monodose pharmaceutical vial;bending the one or more articulating joints to form the folded configuration of the multi-monodose container in response to exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials, wherein the folded configuration of the multi-monodose container has a second rectangular packing cross-sectional area that is smaller than the first rectangular packing cross-sectional area of the expanded configuration; andsealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container therein. 2. The method of claim 1, wherein covering the multi-monodose container in an expanded configuration with the hermetically-sealable overwrap comprises: inserting the multi-monodose container in an expanded configuration through an opening defined by the hermetically-sealable overwrap. 3. The method of claim 1, wherein covering the multi-monodose container in an expanded configuration with the hermetically-sealable overwrap comprises: positioning the multi-monodose container in an expanded configuration between a first layer of hermetically-sealable overwrap and a second layer of hermetically-sealable overwrap; and sealing together one or more edges of the first layer and the second layer of the hermetically-sealable overwrap. 4. The method of claim 1, wherein covering the multi-monodose container in an expanded configuration with the hermetically-sealable overwrap comprises: covering the multi-monodose container in an expanded configuration with a hermetically-sealable foil laminate. 5. The method of claim 1, wherein covering the multi-monodose container in an expanded configuration with the hermetically-sealable overwrap comprises: covering the multi-monodose container in an expanded configuration with at least one of a gas-impermeable overwrap, a vapor-impermeable overwrap, or a light-impermeable overwrap. 6. The method of claim 1, wherein covering the multi-monodose container in an expanded configuration with the hermetically-sealable overwrap comprises: covering the multi-monodose container in an expanded configuration with an electrostatic discharge-protective overwrap. 7. The method of claim 1, wherein the multi-monodose container is formed by a blow-fill-seal manufacturing process. 8. The method of claim 1, wherein the dose of the at least one pharmaceutical agent comprises: a dose of at least one vaccine. 9. The method of claim 1, wherein the articulating joint is frangible. 10. The method of claim 1, wherein exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials comprises: exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials with at least one mechanical probe. 11. The method of claim 1, wherein exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials comprises: exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials with pressurized gas. 12. The method of claim 1, wherein exerting the force on the at least one of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials comprises: exerting a force on a first monodose pharmaceutical vial at a first end of the row of interconnected monodose pharmaceutical vials towards a first adjacent monodose pharmaceutical vial and exerting a force on a second monodose pharmaceutical vial at a second end of the row of interconnected monodose pharmaceutical vials toward a second adjacent monodose pharmaceutical vial. 13. The method of claim 12, further comprising simultaneously exerting the force on the first monodose pharmaceutical vial at the first end of the row of monodose pharmaceutical vials towards the first adjacent monodose pharmaceutical vial and exerting the force on the second monodose pharmaceutical vial at the second end of the row of monodose pharmaceutical vials toward a second adjacent monodose pharmaceutical vial. 14. The method of claim 12, further comprising sequentially exerting the force on the first monodose pharmaceutical vial at the first end of the row of monodose pharmaceutical vials towards the first adjacent monodose pharmaceutical vial and exerting the force on the second monodose pharmaceutical vial at the second end of the row of monodose pharmaceutical vials toward a second adjacent monodose pharmaceutical vial. 15. The method of claim 1, comprising: evacuating at least a portion of air from around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap; andsealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container therein. 16. The method of claim 15, wherein evacuating the at least a portion of the air from around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap comprises: inserting a flow conduit connected to a vacuum source into an opening defined by the hermetically-sealable overwrap;pressure sealing a portion of the hermetically-sealable overwrap around the inserted flow conduit to form a pocket around the folded configuration of the multi-monodose container; andevacuating the at least a portion of the air from the pocket around the folded configuration of the multi-monodose container. 17. The method of claim 1, comprising: injecting an inert gas around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap; andevacuating at least a portion of the injected inert gas from around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap. 18. The method of claim 17, wherein evacuating the at least a portion of the injected inert gas from around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap comprises: inserting a flow conduit connected to a vacuum source into an opening defined by the hermetically-sealable overwrap;pressure sealing a portion of the hermetically-sealable overwrap around the inserted flow conduit to form a pocket around the folded configuration of the multi-monodose container; andevacuating the at least a portion of the injected inert gas from the pocket around the folded configuration of the multi-monodose container. 19. The method of claim 17, further comprising: evacuating at least a portion of air from around the folded configuration of the multi-monodose container covered by the hermetically-sealable overwrap prior to injecting the inert gas around the folded configuration of the multi-monodose container. 20. The method of claim 1, wherein sealing the hermetically-sealable overwrap to form the hermetic seal around the folded configuration of the multi-monodose container therein comprises: at least one of heat-sealing, pressure-sealing, or chemically sealing the hermetically-sealable overwrap to form the hermetic seal around the folded configuration of the multi-monodose container therein. 21. The method of claim 1, further comprising: attaching at least one label to an outer surface of the hermetically-sealable overwrap, the at least one label including at least one sensor. 22. A method of packaging a multi-monodose container, comprising: covering the multi-monodose container with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials polygonal in horizontal cross-section and enclosing a dose of at least one pharmaceutical agent; andone or more articulating joints connecting each of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials to at least one adjacent monodose pharmaceutical vial, the one or more articulating joints sufficiently flexible to reversibly mate a planar outer surface of each of the monodose pharmaceutical vials with a planar outer surface of the at least one adjacent monodose pharmaceutical vial to form a folded configuration of the multi-monodose container;exerting a force on at least a portion of an external surface of the hermetically-sealable overwrap covering the multi-monodose container, the exerted force directed toward the one or more articulating joints of the multi-monodose container;evacuating at least a portion of air from around the multi-monodose container covered by the hermetically-sealable overwrap; andsealing the hermetically-sealable overwrap covering the multi-monodose container to hermetically seal the multi-monodose container therein. 23. The method of claim 22, wherein covering the multi-monodose container with the hermetically-sealable overwrap comprises: inserting the multi-monodose container through an opening defined by the hermetically-sealable overwrap. 24. The method of claim 22, wherein covering the multi-monodose container with the hermetically-sealable overwrap comprises: positioning the multi-monodose container between a first layer of hermetically-sealable overwrap and a second layer of hermetically-sealable overwrap; andsealing together one or more edges of the first layer and the second layer of the hermetically-sealable overwrap. 25. The method of claim 22, wherein covering the multi-monodose container with the hermetically-sealable overwrap comprises: covering the multi-monodose container with a hermetically-sealable foil laminate. 26. The method of claim 22, wherein covering the multi-monodose container with the hermetically-sealable overwrap comprises: covering the multi-monodose container with at least one of a gas-impermeable overwrap, a vapor-impermeable overwrap, or a light-impermeable overwrap. 27. The method of claim 22, wherein covering the multi-monodose container with the hermetically-sealable overwrap comprises: covering the multi-monodose container with an electrostatic discharge-protective overwrap. 28. The method of claim 22, wherein the multi-monodose container is formed by a blow-fill-seal manufacturing process. 29. The method of claim 22, wherein the dose of the at least one pharmaceutical agent comprises a dose of at least one vaccine. 30. The method of claim 22, wherein exerting the force on the at least a portion of the external surface of the hermetically-sealable overwrap covering the multi-monodose container comprises: exerting the force on the at least a portion of the external surface of the hermetically-sealable overwrap covering the multi-monodose container with pressurized gas. 31. The method of claim 22, wherein evacuating the at least a portion of the air from around the multi-monodose container covered by the hermetically-sealable overwrap comprises: inserting a flow conduit connected to a vacuum source into an opening defined by the hermetically-sealable overwrap;pressure sealing a portion of the hermetically-sealable overwrap around the inserted flow conduit to form a pocket around the multi-monodose container; andevacuating the at least a portion of the air from the pocket around the multi-monodose container. 32. The method of claim 22, further comprising: injecting an inert gas around the multi-monodose container covered by the hermetically-sealable overwrap; and evacuating at least a portion of the injected inert gas from around the multi-monodose container covered by the hermetically-sealable overwrap. 33. The method of claim 32, further comprising: evacuating the at least a portion of the air from around the multi-monodose container covered by the hermetically-sealable overwrap prior to injecting the inert gas into the hermetically-sealable overwrap. 34. The method of claim 22, wherein exerting the force on the at least a portion of the external surface of the hermetically-sealable overwrap covering the multi-monodose container comprises: exerting the force on the at least a portion of the external surface of the hermetically-sealable overwrap covering the multi-monodose container with one or more mechanical probes. 35. The method of claim 22, wherein sealing the hermetically-sealable overwrap covering the multi-monodose container to hermetically seal the multi-monodose container therein comprises: sealing a first layer of hermetically-sealable overwrap to a second layer of hermetically-sealable overwrap to hermetically seal the multi-monodose container therein. 36. The method of claim 22, wherein sealing the hermetically-sealable overwrap covering the multi-monodose container to hermetically seal the multi-monodose container therein comprises: bonding at least a portion of the hermetically-sealable overwrap covering the multi-monodose container to at least a portion of a surface of the multi-monodose container to hermetically seal the multi-monodose container therein. 37. The method of claim 36, wherein bonding the at least a portion of the hermetically-sealable overwrap covering the multi-monodose container to the at least a portion of the surface of the multi-monodose container to hermetically seal the multi-monodose container therein comprises: bonding at least a portion of the hermetically-sealable overwrap covering the multi-monodose container to at least a portion of a surface of the multi-monodose container associated with the one or more articulating joints to hermetically seal the multi-monodose container therein. 38. The method of claim 36, wherein bonding the at least a portion of the hermetically-sealable overwrap to the at least a portion of the surface of the multi-monodose container therein comprises: bonding at least a portion of the hermetically-sealable overwrap covering the multi-monodose container to at least a portion of a surface of the multi-monodose container around and between each of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials. 39. The method of claim 22, wherein sealing the hermetically-sealable overwrap covering the multi-monodose container to hermetically seal the multi-monodose container therein comprises: at least one of heat-sealing, pressure-sealing, or chemically sealing the hermetically-sealable overwrap covering the multi-monodose container to hermetically seal the multi-monodose container therein. 40. The method of claim 22, further comprising: attaching at least one label to an outer surface of the hermetically-sealable overwrap, the at least one label including at least one sensor. 41. The method of claim 22, further comprising: bending the hermetically sealed multi-monodose container at the one or more articulating joints of the multi-monodose container to form the folded configuration; and adding a tertiary covering to maintain the hermetically sealed multi-monodose container in the folded configuration. 42. The method of claim 22, comprising: at least partially perforating the hermetically-sealable overwrap to add a frangible portion to the hermetically-sealable overwrap between each of the monodose pharmaceutical vials in the row of interconnected monodose pharmaceutical vials.