In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In add
In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.
대표청구항▼
1. A method, comprising: providing an osteoinductive implant material comprising an osteoconductive scaffolding material incorporating an osteoinductive protein;coating exterior surfaces of the osteoinductive implant material with a biodegradable barrier substance to form a coated implant material,
1. A method, comprising: providing an osteoinductive implant material comprising an osteoconductive scaffolding material incorporating an osteoinductive protein;coating exterior surfaces of the osteoinductive implant material with a biodegradable barrier substance to form a coated implant material, wherein said biodegradable barrier substance is effective to delay release of the osteoinductive protein from the scaffolding material; andimplanting said coated implant material in a patient at a site at which bone growth is needed,wherein said coating is conducted in a sterile operating field. 2. The method of claim 1, wherein said osteoinductive protein comprises a bone morphogenic protein, and wherein said scaffolding material exhibits a capacity to bind said bone morphogenic protein. 3. The method of claim 2, wherein said providing comprises incorporating said osteoinductive protein into said osteoconductive scaffolding material to prepare said osteoinductive implant material, and wherein said incorporating is conducted in the sterile operating field. 4. The method of claim 3, wherein sulfated glycosaminoglycan molecules are bound to said scaffolding material, and wherein said bone morphogenic protein exhibits a capacity to bind to said sulfated glycosaminoglycan molecules. 5. The method of claim 1, further comprising binding sulfated glycosaminoglycan molecules to said scaffolding material using end point binding, wherein said osteoinductive protein exhibits a capacity to bind to said sulfated glycosaminoglycan molecules. 6. The method of claim 5, wherein said sulfated glycosaminoglycan molecules comprise at least one of heparin and dextran sulfate. 7. The method of claim 1, further comprising binding sulfated glycosaminoglycan molecules to said scaffolding material using an aminosilane coupling agent, wherein said osteoinductive protein exhibits a capacity to bind to said sulfated glycosaminoglycan molecules. 8. The method of claim 1, further comprising binding sulfated glycosaminoglycan molecules to said scaffolding material by covalent crosslinking using glutaraldehyde as a coupling agent, wherein said osteoinductive protein exhibits a capacity to bind to said sulfated glycosaminoglycan molecules. 9. The method of claim 1, further comprising treating surfaces of said scaffolding material by adding one of a negative surface charge and a positive surface charge to increase binding of said osteoinductive protein to said scaffolding material. 10. The method of claim 1, wherein said providing comprises incorporating sulfated glycosaminoglycan molecules on a precursor material and processing said precursor material to form said scaffolding material, wherein said osteoinductive protein exhibits a capacity to bind to said sulfated glycosaminoglycan molecules. 11. The method of claim 1, further comprising ionically crosslinking alginate using an ionic crosslinking agent comprising calcium chloride to form said biodegradable barrier substance. 12. The method of claim 1, wherein said biodegradable barrier substance comprises a liquid organic binder that includes ionic polysaccharides that are capable of forming thermally-irreversible ionically-crosslinked gels, and said method further comprises implanting said coated implant material in a patient at a site at which bone growth is needed by co-administering said coated implant material with a liquid medium of an ionic crosslinker. 13. The method of claim 12, wherein said co-administering comprises moving said coated implant material through a first barrel of a syringe and moving said liquid medium through a second barrel of said syringe such that said coated implant material and said liquid medium are admixed as they exit said syringe. 14. The method of claim 1, wherein said biodegradable barrier substance comprises a liquid organic binder that includes ionic polysaccharides that are capable of forming thermally-irreversible ionically-crosslinked gels, and said method further comprises implanting said coated implant material in a patient at a site at which bone growth is needed by administering said coated implant material without an ionic crosslinker. 15. The method of claim 1, further comprising implanting said coated implant material in a patient at a site at which bone growth is needed by incorporating said coated implant material within a load-bearing spinal implant. 16. The method of claim 15, wherein said load-bearing spinal implant is a fusion cage. 17. The method of claim 15, wherein said load-bearing spinal implant has a compression strength of at least 10,000 N. 18. The method of claim 1, wherein said providing comprises removing said osteoinductive implant material from a sterile package in a sterile operating field and said coating exterior surfaces of the osteoinductive implant material comprises applying said biodegradable barrier substance as a coating on said osteoinductive implant material while in the operating field.
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