Compounds of the formulae and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of the formula wherein G1 is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9-phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycl
Compounds of the formulae and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of the formula wherein G1 is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9-phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycloalkyl; phenyl; or C7-C9-phenylalkyl; E is oxyl or hydroxyl; V is —O—; or —NH—; a is 0 or 1 or 2;b, c and d and g are each independently of one another 0 or 1;e is an integer from 1 to 4;f, m, n and p are each independently of one another an integer from 1 to 3;q is 0 or an integer from 1 to 3;Q, T and G3 are as defined in claim 1; G4 and G5 are each independently of the other hydrogen; or C1-C22alkyl;exhibit marked antiinflammatory action.
대표청구항▼
1. A method for the local treatment or prevention of inflammatory conditions comprising: administering to a patient in need of such treatment an effective amount of a pharmaceutical composition comprising at least one of the following compounds of formulae (7) to (35) the reaction product of glyceri
1. A method for the local treatment or prevention of inflammatory conditions comprising: administering to a patient in need of such treatment an effective amount of a pharmaceutical composition comprising at least one of the following compounds of formulae (7) to (35) the reaction product of glycerine, coconut oil and a compound of the formula together with a pharmaceutically acceptable carrier or adjuvant, wherein the pharmaceutical composition is free from skin-lightening agents. 2. The method according to claim 1, wherein the compounds (7) to (35) are present in a total amount of 0.001 to 10% by weight of the total composition. 3. The method according to claim 1, which additionally comprises at least one substance selected from antiphlogistic agents, antiinflammatory agents, vitamins, antipsoriatic agents, further skin actives, cell proliferation regulators, antiallergic, UV protecting, moisturizing, antiageing agents, DNA-protectants. 4. The method according to claim 1, which contains the compounds (7) to (35), and optionally a further active ingredient, in nanodispersed or encapsulated form. 5. The method according to claim 1, wherein the following compounds are administered to a patient in need are selected from the group consisting of AO3:a reaction product of glycerine, coconut oil and a compound of the formula (mixture of mono-, di- and triglycerides of β-(3,5-di-tert.butyl-4-hydroxyphenyl) propanoic acid and fatty acids, CAS Reg.-No. 179986-09-5)AO5a mixture of the compounds of the formulae: andAO7: a pentaerythritol-tetrakis(3-[3′,5′-di-tert.butyl-4′-hydroxyphenyl]-propionate) 6. The method according to claim 1, wherein the compounds administered to the patient in need is selected from the group consisting of AO3:a reaction product of glycerine, coconut oil and a compound of the formula a mixture of the compounds of the formulae: AO7: a pentaerythritol-tetrakis(3-[3′,5′-di-tert.butyl-4′-hydroxyphenyl]-propionate) 7. The method according to claim 1, comprising administering the pharmaceutical composition to the patient in need of local treatment or prevention of inflammatory conditions for other than an after-sun inflammatory condition. 8. The method according to claim 1, wherein the inflammatory condition is an adverse radical induced inflammatory condition selected from the group consisting of collagen damage inflammation, reperfusion damage inflammation, DNA-damage inflammation, and combinations thereof. 9. The method according to claim 1, wherein the inflammatory condition is an adverse radical induced inflammatory condition selected from the group consisting of reperfusion damage inflammation, DNA-damage inflammation, and combinations thereof.
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이 특허에 인용된 특허 (4)
Meyer,Knut; Viitanen,Paul V.; Flint,Dennis, High Level production of arbutin in green plants.
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