The present invention relates to a buccal delivery dosage form and its use for administration of a therapeutic gas for buccal mucosal absorption of the therapeutic gas in the mouth of a subject. The buccal delivery dosage form comprises at least one crystallized excipient and at least one therapeuti
The present invention relates to a buccal delivery dosage form and its use for administration of a therapeutic gas for buccal mucosal absorption of the therapeutic gas in the mouth of a subject. The buccal delivery dosage form comprises at least one crystallized excipient and at least one therapeutic gas entrapped within the crystallized excipient.
대표청구항▼
1. A method for administering a therapeutic gas to a patient in need thereof, said method comprising administering in the mouth of said patient in need of such therapeutic gas a buccal delivery dosage form comprising: a) at least one crystallized excipient; andb) at least one therapeutic gas entrapp
1. A method for administering a therapeutic gas to a patient in need thereof, said method comprising administering in the mouth of said patient in need of such therapeutic gas a buccal delivery dosage form comprising: a) at least one crystallized excipient; andb) at least one therapeutic gas entrapped within the crystallized excipient,wherein said buccal delivery dosage form releases the therapeutic gas entrapped therein upon solubilization of said crystallized excipient in contact with the saliva in the mouth of the patient, said gas being absorbed through the buccal mucosa, and wherein said buccal delivery dosage form does not contain any additional active ingredient. 2. The method of claim 1, wherein the crystallized excipient is a sugar or a polyol. 3. The method of claim 2, wherein the sugar is a sugar commercially available in the confectionary industry. 4. The method of claim 2, wherein the sugar is selected from the group consisting of glucose, fructose, sucrose, lactose, corn syrup, starch syrup, and glucose syrup. 5. The method of claim 2, wherein the polyol is a polyol commercially available in the confectionary industry. 6. The method of claim 2, wherein the polyol is selected from the group consisting of isomalt, lactitol, maltitol, mannitol, sorbitol, xylitol, and isosorbide. 7. The method of claim 1, wherein the therapeutic gas is a noble gas. 8. The method of claim 1, wherein the therapeutic gas is selected from the group consisting of acetylene, argon, ethylene, helium, hydrogen, hydrogen sulfide, krypton, neon, nitrogen, nitric oxide, oxygen, ozone, sulfur dioxide, and xenon. 9. The method of claim 1, wherein the crystallized excipient contains about 1.3 to about 1.38 ml of therapeutic gas entrapped therein. 10. A method for reducing stress and/or anxiety, said method comprising the step of administering in the in the mouth of a patient in need of such treatment a buccal delivery dosage form comprising: a) at least one crystallized excipient; andb) argon gas entrapped within the crystallized excipient,wherein said buccal delivery dosage form releases the argon gas entrapped therein upon solubilization of said crystallized excipient in contact with the saliva in the mouth of the patient, said argon gas being absorbed through the buccal mucosa for relieving stress and/or anxiety. 11. The method of claim 10, wherein the crystallized excipient contains about 1.3 to about 1.38 ml of argon gas entrapped therein.
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이 특허에 인용된 특허 (5)
Kirkpatrick Paul A. (New Rochelle NY), Incorporating a gas in candy.
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