IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0864934
(2009-02-02)
|
등록번호 |
US-10112019
(2018-10-30)
|
우선권정보 |
GB-0802028.1 (2008-02-05) |
국제출원번호 |
PCT/EP2009/000658
(2009-02-02)
|
§371/§102 date |
20100819
(20100819)
|
국제공개번호 |
WO2009/098010
(2009-08-13)
|
발명자
/ 주소 |
|
출원인 / 주소 |
- Boehringer Ingelheim Pharma GmbH & Co. KG
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
10 |
초록
▼
An inhaler for use with a dry powder pharmaceutical formulation, including: a chamber containing the dry powder formulation, a valve disposed in series with the chamber for regulating air flow through the chamber, and a bypass coupled around the combination of the chamber and the valve, where the va
An inhaler for use with a dry powder pharmaceutical formulation, including: a chamber containing the dry powder formulation, a valve disposed in series with the chamber for regulating air flow through the chamber, and a bypass coupled around the combination of the chamber and the valve, where the valve and bypass cooperate for ensuring that the air flow is at least essentially fixed or kept constant or at a minimum accepted or desired or required flow rate through the chamber, and for varying air flow restriction through the inhaler with flow rate, or for keeping the air flow restriction generally constant.
대표청구항
▼
1. An inhaler (I), comprising: an inlet into which air is drawn,an outlet through which air exits,a pharmaceutical medicament formed of a loose, dry powder formulation for suspension in the air and being entrained by an air flow of the air generated passively, by which a patient draws the air via in
1. An inhaler (I), comprising: an inlet into which air is drawn,an outlet through which air exits,a pharmaceutical medicament formed of a loose, dry powder formulation for suspension in the air and being entrained by an air flow of the air generated passively, by which a patient draws the air via inhalation to create the air flow and a resultant aerosol,a chamber (3, 13) containing a pre-metered amount of the dry powder formulation (4, 14), which is in fluid communication with the inlet and the outlet, such that at least some of the air is received from the inlet into the chamber to entrain substantially all of the pre-metered amount of the dry powder formulation and to carry the pre-metered amount of the dry powder formulation out through the outlet,a valve (6) disposed in series with the chamber for varying an extent to which the air flow (8a, 18a) through the chamber (3, 13) may flow, anda bypass (5, 15) coupled from the inlet around the combination of the chamber and the valve, to the outlet such that a total air flow is equal to the air flow through the chamber plus an air flow through the bypass, where the bypass (5, 15) permits at least some of the air to bypass the chamber (3, 13) and permits splitting the total air flow between a primary flow (8a, 18a) through the valve and chamber, and a bypass flow (8b, 18b) through the bypass,wherein the valve (6) is located in the primary flow such that the valve (6) closes with increased total flow such that the valve and bypass cooperate for ensuring that the air flow through the bypass increases as the total air flow increases such that the primary flow (8a, 18a) through the chamber is at least essentially fixed or kept constant through the chamber (3, 13). 2. The inhaler according to claim 1, wherein the inhaler (I) is constructed such that the air is drawn via the inlet (1, 11) and delivered via the combined valve and chamber (3, 13) to the outlet (2, 12). 3. The inhaler according to claim 1, further comprising a further valve (16) disposed in the bypass (5, 15), such that the further valve (16) restricts flow or closes with decreased total flow. 4. The inhaler according to claim 1, wherein the valve and the bypass cooperate such that more air is forced to go via the bypass (5, 15) as the total flow rate increases. 5. The inhaler according to claim 1, wherein the valve and bypass cooperate such that a pressure drop or restriction across the inhaler (I) is kept generally constant. 6. The inhaler according to claim 1, wherein the valve (6) is located upstream of the chamber (3, 13). 7. The inhaler according to claim 1, wherein the valve (6) is a flow regulating valve. 8. The inhaler according to claim 1, wherein the inhaler (I) comprises pre-metered doses of the powder (4, 14) in chambers (3, 13), which include at least one of capsules, blisters, and a reservoir (R). 9. The inhaler according to claim 1, wherein the valve (6) comprises a plunger (22) that is biased by means of a spring (25) so that the valve (6) can be closed or restrict the air flow through the valve (6) when the air flow increases the pressure on the plunger (22). 10. An inhaler (I), comprising: an inlet into which air is drawn,an outlet through which air exits,a pharmaceutical medicament formed of a loose, dry powder formulation for suspension in the air and being entrained by an air flow of the air generated passively, by which a patient draws the air via inhalation to create the air flow and a resultant aerosol,a chamber (3, 13) containing a pre-metered amount of the dry powder formulation (4, 14), which is in fluid communication with the inlet and the outlet, such that at least some of the air is received from the inlet into the chamber to entrain substantially all of the pre-metered amount of the dry powder formulation and to carry the pre-metered amount of the dry powder formulation out through the outlet,a valve (6) disposed in series with the chamber for varying an extent to which the air flow (8a, 18a) through the chamber (3, 13) may flow, anda bypass (5, 15) coupled from the inlet around the combination of the chamber and the valve to the outlet such that a total air flow is equal to the air flow through the chamber plus an air flow through the bypass,wherein the valve and bypass cooperate for ensuring that the air flow through the bypass increases as the total air flow increases such that the air flow (8a, 18a) through the chamber is at least essentially fixed or kept constant through the chamber (3, 13),wherein the valve is pre-adjustable to set the air flow through the chamber to match an inhalation capacity of a user, andwherein the valve (6) comprises a plunger (22) that is biased by means of a spring (25) so that the valve (6) can be closed or restrict the air flow through the valve (6) when the air flow increases the pressure on the plunger (22). 11. An inhaler (I), comprising: an inlet into which air is drawn,an outlet through which air exits,a pharmaceutical medicament formed of a loose, dry powder formulation for suspension in the air and being entrained by an air flow of the air generated passively, by which a patient draws the air via inhalation to create the air flow and a resultant aerosol,a chamber (3, 13) containing a pre-metered amount of the dry powder formulation (4, 14), which is in fluid communication with the inlet and the outlet, such that at least some of the air is received from the inlet into the chamber to entrain substantially all of the pre-metered amount of the dry powder formulation and to carry the pre-metered amount of the dry powder formulation out through the outlet,a valve (6) disposed in series with the chamber for varying an extent to which the air flow (8a, 18a) through the chamber (3, 13) may flow, anda bypass (5, 15) coupled from the inlet around the combination of the chamber and the valve, to the outlet such that a total air flow is equal to the air flow through the chamber plus an air flow through the bypass, where the bypass (5, 15) permits at least some of the air to bypass the chamber (3, 13) and permits splitting the total air flow between a primary flow (8a, 18a) through the valve and chamber, and a bypass flow (8b, 18b) through the bypass,wherein the valve (6) is located in the primary flow such that the valve (6) at least one of restricts flow and closes with increased total flow such that the valve and bypass cooperate for ensuring that the air flow through the bypass increases as the total air flow increases such that the primary flow (8a, 18a) through the chamber is at least essentially fixed or kept constant through the chamber (3, 13), andwherein the valve (6) comprises a plunger (22) that is biased by means of a spring (25) so that the valve (6) can be closed or restrict the air flow through the valve (6) when the air flow increases the pressure on the plunger (22).
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