An example system determines biomechanical properties of eye tissue. The system includes a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the tissue. The incident light is reflected by the plurality of cross-sections of tissue as scattered li
An example system determines biomechanical properties of eye tissue. The system includes a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the tissue. The incident light is reflected by the plurality of cross-sections of tissue as scattered light. The system includes a spectrometer to receive the scattered light and provide spectral information for the scattered light. The system includes processor(s) to determine a Brillouin frequency shift from the spectral information and to generate a three-dimensional profile of the corneal tissue according to the Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the tissue. The spectrometer includes a multipass optical device that generates an interference pattern from the scattered light. The interference pattern provides the spectral information for the scattered light. The spectrometer includes a camera to detect the interference pattern from the optical device.
대표청구항▼
1. An optical device, comprising: a reflective first surface;a partially reflective/transmissible second surface parallel to the first surface, the second surface being spaced from the first surface to define an optical cavity therebetween, the optical cavity having a first end and a second end;an e
1. An optical device, comprising: a reflective first surface;a partially reflective/transmissible second surface parallel to the first surface, the second surface being spaced from the first surface to define an optical cavity therebetween, the optical cavity having a first end and a second end;an entrance window disposed at the first end of the optical cavity and opposite the second surface, the entrance window configured to transmit light including light rays into the optical cavity and to allow the light rays to travel to the second surface, causing the light rays to be reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the second end of the optical cavity in a first pass; anda first reflective element disposed at the second end of the optical cavity and opposite the second surface, the first reflective element positioned and oriented to receive the light rays traveling from the second surface and along a direction determined by reflection of the light rays between the first and second surfaces during the first pass, the first reflective element configured to reflect the light rays further to the second surface after the first pass, causing the light rays to be further reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the first end of the optical cavity in a second pass, the light rays traveling a first optical path length from the second surface to the first reflective element and back to the second surface, the light rays traveling a second optical path length from the second surface to the first surface and back to the second surface during the second pass, the first optical path length being an integer multiple of the second optical path,wherein a portion of light from the light rays is transmitted through the second surface with each reflection at the second surface, the transmitted portions of light generating an interference pattern that provides spectral information for the light. 2. The optical device of claim 1, further comprising a second reflective element disposed at the first end of the optical cavity and opposite the second surface, the second reflective element configured to reflect the light rays to the second surface after the second pass, causing the light rays to be further reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the second end of the optical cavity in a third pass, the light rays traveling a third optical path length from the second surface to the second reflective element and back to the second surface, the light rays traveling a fourth optical path length from the second surface to the first surface and back to the second surface during the third pass, the third optical path length being an integer multiple of the fourth optical path. 3. The optical device of claim 2, wherein the first reflective element and the second reflective element cause the light rays to traverse the optical cavity between the first and second ends in additional passes, the light rays reflecting between the first and second surfaces during each additional pass. 4. The optical device of claim 2, further comprising an exit window disposed at the second end of the optical cavity and opposite the second surface, wherein the light rays exit the optical cavity through the exit window. 5. The optical device of claim 4, wherein the optical cavity further includes a first side and a second side, the entrance window being further disposed at the first side of the optical cavity and the exit window being further disposed at the second side of the optical cavity, wherein the light ray further traverses the optical cavity from the first side to the second side with each pass from the first end to the second end until the light ray exits the optical cavity through the exit window. 6. The optical device of claim 4, further comprising a thermally stable substrate having a first face and a second face, the first face parallel to the second face, wherein the reflective first surface, the entrance window, and the exit window are formed on the first face of the substrate,the partially reflective/transmissible second surface is formed on the second face of the substrate, andthe optical cavity is defined within the substrate. 7. The optical device of claim 6, further comprising: a transmissible third surface disposed at the first end of the optical cavity and formed on the first face of the substrate; anda transmissible fourth surface disposed at the second end of the optical cavity and formed on the first face of the substrate,wherein the first surface is disposed between the third and fourth surfaces,the first reflective element is disposed across a first portion of the fourth surface and the exit window is defined by a second portion of the fourth surface across which the first reflective element is not disposed, andthe second reflective element is disposed across a first portion of the third surface and the entrance window is defined by a second portion of the third surface across which the second reflective element is not disposed. 8. The optical device of claim 7, wherein the first reflective element includes a first mirror coupled to the substrate and positioned across the first portion of the fourth surface, and the second reflective element includes a second mirror coupled to the substrate and positioned across the first portion of the third surface. 9. The optical device of claim 6, wherein the first reflective element is formed on a first angled portion of the first face of the substrate and the first reflective element is formed on a second angled portion of the first face of the substrate. 10. The optical device of claim 6, wherein the substrate includes: a third face extending between the first face and the second face at the first end of the optical cavity, anda fourth face extending between the first face and the second face at the second end of the optical cavity,wherein the first reflective element is formed on the fourth face of the substrate, and the second reflective element is formed on the third face of the substrate. 11. An optical device, comprising: a reflective first surface;a partially reflective/transmissible second surface parallel to the first surface, the second surface being spaced from the first surface to define an optical cavity therebetween, the optical cavity having a first end and a second end;an entrance window disposed at the first end of the optical cavity and opposite the second surface, the entrance window configured to transmit light including light rays into the optical cavity and to allow the light rays to travel to the second surface, causing the light rays to be reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the second end of the optical cavity in a first pass;a first reflective element disposed at the second end of the optical cavity and opposite the second surface; anda second reflective element disposed at the first end of the optical cavity and opposite the second surface,wherein the first reflective element and the second reflective element cause the light rays to traverse the optical cavity between the first and second ends in additional passes, the light rays reflecting between the first and second surfaces during each additional pass,wherein the light rays travel a first optical path length from the second surface to the first reflective element and back to the second surface, the light rays travel a second optical path length from the second surface to the first surface and back to the second surface during the second pass, the first optical path length is an integer multiple of the second optical path,wherein the light rays travel a third optical path length from the second surface to the second reflective element and back to the second surface, the light rays travel a fourth optical path length from the second surface to the first surface and back to the second surface during the third pass, the third optical path length is an integer multiple of the fourth optical path, andwherein a portion of light from the light rays is transmitted through the second surface with each reflection at the second surface, the transmitted portions of light generating an interference pattern that provides spectral information for the light. 12. A system that determines biomechanical properties of corneal tissue, comprising: a light source configured to provide an incident light;a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the corneal tissue, the incident light being reflected by the plurality of cross-sections of corneal tissue as scattered light;a spectrometer configured to receive the scattered light and provide spectral information for the received scattered light; andone or more processors configured to determine a Brillouin frequency shift from the spectral information and to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift, the three-dimensional profile providing an indicator of one or more biomechanical properties of the corneal tissue,wherein the spectrometer includes: an optical device including: a reflective first surface;a partially reflective/transmissible second surface parallel to the first surface, the second surface being spaced from the first surface to define an optical cavity therebetween, the optical cavity having a first end and a second end;an entrance window disposed at the first end of the optical cavity and opposite the second surface, the entrance window configured to transmit the scattered light including light rays into the optical cavity and to allow the light rays to travel to the second surface, causing the light rays to be reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the second end of the optical cavity in a first pass; anda first reflective element disposed at the second end of the optical cavity and opposite the second surface, the first reflective element positioned and oriented to receive the light rays traveling from the second surface and along a direction determined by reflection of the light rays between the first and second surfaces during the first pass, the first reflective element configured to reflect the light rays further to the second surface after the first pass, causing the light rays to be further reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the first end of the optical cavity in a second pass, the light rays traveling a first optical path length from the second surface to the first reflective element and back to the second surface, the light rays traveling a second optical path length from the second surface to the first surface and back to the second surface during the second pass, the first optical path length being an integer multiple of the second optical path,wherein a portion of light from the light rays is transmitted through the second surface with each reflection at the second surface, the transmitted portions of light generating an interference pattern that provides the spectral information for the scattered light; anda camera configured to detect the interference pattern from the optical device. 13. The system of claim 12, wherein the spectrometer optical device further includes a second reflective element disposed at the first end of the optical cavity and opposite the second surface, the reflective element configured to reflect the light rays to the second surface after the second pass, causing the light rays to be further reflected between the first and second surfaces multiple times and to traverse the optical cavity toward the second end of the optical cavity in a third pass, the light rays traveling a third optical path length from the second surface to the second reflective element and back to the second surface, the light rays traveling a fourth optical path length from the second surface to the first surface and back to the second surface during the third pass, the third optical path length being an integer multiple of the fourth optical path. 14. The system of claim 13, wherein the first reflective element and the second reflective element cause the light rays to traverse the optical cavity between the first and second ends in additional passes, the light rays reflecting between the first and second surfaces during each additional pass. 15. The system of claim 13, wherein the spectrometer optical device further includes an exit window disposed at the second end of the optical cavity and opposite the second surface, wherein the light rays exit the optical cavity through the exit window. 16. The system of claim 15, wherein the optical cavity further includes a first side and a second side, the entrance window being further disposed at the first side of the optical cavity and the exit window being further disposed at the second side of the optical cavity, wherein the light ray further traverses the optical cavity from the first side to the second side with each pass from the first end to the second end until the light ray exits the optical cavity through the exit window. 17. The system of claim 15, wherein the spectrometer optical device further includes a thermally stable substrate having a first face and a second face, the first face parallel to the second face, wherein the reflective first surface, the entrance window, and the exit window are formed on the first face of the substrate,the partially reflective/transmissible second surface is formed on the second face of the substrate, andthe optical cavity is defined within the substrate. 18. The system of claim 12, wherein the spectrometer further includes: a collimating lens configured to collimate the scattered light; anda focusing lens configured to direct the collimated light to the entrance window of the optical device. 19. The system of claim 12, wherein the spectrometer further includes a Fourier lens aligned with the optical device and configured to direct the interference pattern to the camera in a fringe pattern separating wavelengths of the scattered light at respective angles, wherein the spectrometer camera includes a light-sensitive array disposed at an imaging plane of the Fourier lens, each element of the light sensitive array sampling a respective angle of the fringe pattern, each angle providing an intensity for the respective wavelength. 20. The system of claim 12, wherein the spectrometer includes a mount for receiving the optical device, wherein the optical device further includes pins that contact mount points of the mount to minimize shear forces on the optical device.
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