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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0706449 (2015-05-07) |
| 등록번호 | US-10130783 (2018-11-20) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 361 |
The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of
The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising: a first lumen, a second lumen and a cannula nosepiece: the first lumen being a nitric oxide lumen connected to a nitric oxide source, the second lumen being a trigger lumen and/or an oxygen l
1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising: a first lumen, a second lumen and a cannula nosepiece: the first lumen being a nitric oxide lumen connected to a nitric oxide source, the second lumen being a trigger lumen and/or an oxygen lumen; andthe first lumen and the second lumen aggregating at the cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for the first lumen and the second lumen such that the nitric oxide and the oxygen do not mix in the cannula nosepiece, wherein the first lumen has an inner diameter that is smaller than the inner diameter of the second lumen but larger than an inner diameter of the flow path for the first lumen at the cannula nosepiece. 2. The nasal cannula of claim 1, wherein the flow path for the first lumen at the cannula nosepiece comprises a first prong, a second prong and a backplane, with the first prong being in fluid communication with the second prong via the backplane and the total volume of the first prong, the second prong and the backplane being less than 0.035 mL. 3. The nasal cannula of claim 1, wherein the nasal cannula (i) reduces dilution of one or more of the nitric oxide and the oxygen gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both. 4. The nasal cannula of claim 1, wherein the nasal cannula reduces delivery of nitrogen dioxide to the patient. 5. The nasal cannula of claim 1, wherein the nasal cannula delivers one or more of the nitric oxide and the oxygen gases to the patient for treatment of pulmonary hypertension. 6. The nasal cannula of claim 5, wherein the nasal cannula delivers one or more of the nitric oxide and the oxygen gases to the patient for treatment of at least one of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), pulmonary hypertension as pulmonary arterial hypertension (PAH), pulmonary hypertension secondary to idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension secondary to sarcoidosis. 7. The nasal cannula of claim 1, wherein the first lumen is six feet to eight feet in length having an inner diameter of 0.01 inches to 0.10 inches. 8. The nasal cannula of claim 1, wherein the cannula comprises a wall material having a low oxygen transmission rate that is between 0.001(cc)(mil)(24hrs)(100in2)(ATM)and10(cc)(mil)(24hrs)(100in2)(ATM). 9. The nasal cannula of claim 1, further comprising one or more of: (i) at least one check valve in fluid communication with the first lumen, (ii) a cannula key, and (iii) a scavenging material. 10. The nasal cannula of claim 1, wherein the cannula nosepiece is further comprising a flexible support bridge that cushions the patient's the nasal septum. 11. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising: a first lumen and a second lumen: the first lumen connected to a nitric oxide source and being a combined first therapeutic gas and triggering lumen for both delivering a first therapeutic gas comprising nitric oxide to a patient and triggering, andthe second lumen being a second therapeutic gas lumen for delivering comprising oxygen to the patient;the first lumen and the second lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the combined first therapeutic gas and triggering lumen and (ii) the second therapeutic gas lumen such that the first therapeutic gas and the second therapeutic gas do not mix in the cannula nosepiece;the combined first therapeutic gas and triggering lumen having an inner diameter that is smaller than an inner diameter of the second therapeutic gas lumen; andthe inner diameter of the combined first therapeutic gas and triggering lumen being larger than an inner diameter of the flow path for the combined first therapeutic gas and triggering lumen at the cannula nosepiece. 12. The nasal cannula of claim 11, wherein the flow path for the combined first therapeutic gas and triggering lumen at the cannula nosepiece comprises a first prong, a second prong and a backplane, with the first prong being in fluid communication with the second prong via the backplane and the total volume of the first prong, the second prong and the backplane being less than 0.035 mL. 13. The nasal cannula of claim 11, wherein the nasal cannula (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both. 14. The nasal cannula of claim 11, wherein the nasal cannula reduces delivery of nitrogen dioxide to the patient. 15. The nasal cannula of claim 11, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of pulmonary hypertension. 16. The nasal cannula of claim 15, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of at least one of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), pulmonary hypertension as pulmonary arterial hypertension (PAH), pulmonary hypertension secondary to idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension secondary to sarcoidosis. 17. The nasal cannula of claim 11, wherein the combined first therapeutic gas and triggering lumen is six feet to eight feet in length having an inner diameter of 0.01 inches to 0.10 inches.
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