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특허 상세정보

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Combination therapy intravaginal rings

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61F-006/08    A61F-006/06    A61K-031/567    A61K-031/505    A61K-031/46    A61K-045/06   
출원번호 US-0540530 (2014-11-13)
등록번호 US-10137031 (2018-11-27)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    McCarter & English, LLP
인용정보 피인용 횟수 : 0  인용 특허 : 64
초록
▼

The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intrava...

대표
청구항
▼

1. An intravaginal ring comprising a eutectic composition comprising dapivirine and an antimicrobial compound, wherein less than about 7 mg of dapivirine is released in vitro from said ring during an initial 24 hour period of release,wherein the release rate of the antimicrobial compound from the intravaginal ring in vitro is increased as compared to the release rate of the antimicrobial compound from an intravaginal ring comprising the antimicrobial compound without dapivirine, andwherein the intravaginal ring is a matrix-type ring, or a reservoir-type ...

이 특허에 인용된 특허 (64)

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