Compounding device, system, kit, software, and method
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01F-005/04
B01F-015/02
F16K-005/04
F16K-011/22
A61J-003/00
B01F-003/08
B01F-013/00
B65B-003/12
B01F-005/00
A61M-039/22
A61M-039/24
B01F-013/10
F16K-031/04
F16K-099/00
F16K-011/085
출원번호
US-0719936
(2015-05-22)
등록번호
US-10143985
(2018-12-04)
발명자
/ 주소
Brown, Michael Y.
Lane, Benjamin R.
Mumpower, Mariano
출원인 / 주소
B. BRAUN MEDICAL INC.
대리인 / 주소
Kenealy Vaidya LLP
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
An exemplary compounding system and device for mixing materials from at least two distinct material sources can include a housing, a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container, a second fluid line ope
An exemplary compounding system and device for mixing materials from at least two distinct material sources can include a housing, a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container, a second fluid line operationally connected to the housing and configured to transport a second volume of fluid per unit time to the final container. The device can also include a pump system including, a first pump configured to move a first volume of fluid through a first fluid line, and a second pump configured to move a second volume of fluid through the second fluid line. The pump system can also be configured such that the volume of fluid per unit time delivered by the first and second pumps is different, and/or where the first and second pumps have different head characteristics.
대표청구항▼
1. A compounding device for mixing materials from at least two distinct material sources, comprising: a housing;at least two distinct material sources;a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container;a se
1. A compounding device for mixing materials from at least two distinct material sources, comprising: a housing;at least two distinct material sources;a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container;a second fluid line operationally connected to the housing and configured to transport a second volume of fluid per unit time to the final container, wherein the first volume of fluid per unit time is different from the second volume of fluid per unit time;a manifold connected to the first fluid line and second fluid line and configured to be releasably attached to the housing; anda pump system including, a first pump configured to move the first volume of fluid through the first fluid line, anda second pump configured to move the second volume of fluid through the second fluid line, whereinthe manifold is connected to the first fluid line at a location along the first fluid line between at least one of the two distinct material sources and the first pump. 2. The compounding device of claim 1, wherein the first pump is configured to have a first pump head characteristic, and the second pump is configured to have a second pump head characteristic, and the first pump head characteristic is different from the second pump head characteristic, and the manifold is connected to the second fluid line at a location along the second fluid line between at least another of the two distinct material sources and the second pump. 3. The compounding device of claim 1, wherein the first fluid line has a first cross-sectional flow area defined by a cross-section taken normal to a fluid pathway of the first fluid line, and the second fluid line has a second cross-sectional flow area defined by a cross-section taken normal to a fluid pathway of the second fluid line, wherein the first cross-sectional flow area is different from the second cross-sectional flow area. 4. The compounding device of claim 1, wherein the first pump includes a micro rotor and the second pump includes a macro rotor. 5. The compounding device of claim 4, wherein the first pump includes a micro stepper motor encoded for positional accuracy and connected to the micro rotor, and the second pump includes a macro stepper motor encoded for positional accuracy and connected to the macro rotor. 6. The compounding device of claim 5, wherein the micro rotor and macro rotor are interchangeable with each other, and the macro rotor is configured for connection to the micro stepper motor, and the micro rotor is configured for connection to the macro stepper motor. 7. The compounding device of claim 4, wherein the micro rotor includes a lower flange configured to support a first tube that comprises a portion of the first fluid line and the flange of the micro rotor configured to maintain the first tube in proper position with respect to the micro rotor and the housing, and the macro rotor includes a lower flange configured to support a second tube that comprises a portion of the second fluid line, and the flange of the macro rotor configured to maintain the second tube in proper position with respect to the macro rotor and the housing. 8. The compounding device of claim 4, further comprising: a controller configured to rotate the micro rotor at a first speed and the macro rotor at a second speed, wherein the first speed is different from the second speed. 9. The compounding device of claim 1, further comprising: a transfer set including at least a portion of both the first fluid line and the second fluid line;at least three distinct material sources, each in fluid connection to the transfer set; anda final container in fluid connection to at least one output port of the transfer set. 10. The compounding device of claim 1, further comprising: a transfer set including the manifold and at least a portion of both the first fluid line and the second fluid line, the manifold being located upstream of both the first pump and second pump, the manifold including a micro channel that forms a portion of the first fluid line, and the manifold including a macro channel that forms a portion of the second fluid line, wherein the micro channel and the macro channel are in fluid isolation with respect to each other. 11. The compounding device of claim 10, wherein the micro channel includes a micro channel cross-sectional area defined by a cross-section taken normal to a fluid pathway through the micro channel, and the macro channel includes a macro channel cross-sectional area defined by a cross-section taken normal to a fluid pathway through the macro channel, wherein the micro channel cross-sectional area is smaller than the macro channel cross-sectional area. 12. The compounding device of claim 10, wherein the micro channel includes a plurality of input valves, each of the input valves of the micro channel is configured for connection to one of the distinct material sources, and the macro channel includes a plurality of input valves, each of the input valves of the macro channel is configured for connection to a different one of the distinct material sources. 13. The compounding device of claim 12, wherein at least one of the plurality of input valves in fluid connection with the micro channel is connected to a micro input tubing line, and at least one of the plurality of input valves in fluid connection with the macro channel is connected to a macro input tubing line, wherein a cross-sectional diameter of the micro input tubing line is smaller than a cross-sectional diameter of the macro input tubing line. 14. The compounding device of claim 13, wherein at least one of the plurality of input valves in fluid connection with the micro channel is connected to a macro input tubing line. 15. The compounding device of claim 10, wherein the macro channel of the manifold includes a macro exit port, and the micro channel of the manifold includes a micro exit port, and a cross-sectional diameter of the micro exit port is less than a cross-sectional diameter of the macro exit port. 16. The compounding device of claim 10, wherein the transfer set includes a micro tubing line extending from the micro channel of the manifold to the first pump, and the transfer set includes a macro tubing line extending from the macro channel of the manifold to the second pump, and a cross-sectional diameter of the micro tubing line is less than a cross-sectional diameter of the macro tubing line. 17. A compounding system for mixing materials from at least two distinct material sources, comprising: a pump system including a first pump and a second pump; anda transfer set connected to the pump system, whereinthe transfer set includes a first fluid line and a second fluid line, and the first fluid line is in fluid isolation from the second fluid line, and the first pump has a first volumetric flow rate and the second pump has a second volumetric flow rate, where the first volumetric flow rate is different from the second volumetric flow rate, the transfer set including a manifold located upstream of the first pump and second pump, the manifold including at least one first input port and a first output port forming a portion of the first fluid line, and at least one second input port and a second output port forming a portion of the second fluid line. 18. The compounding system of claim 17, wherein the manifold includes a micro channel that forms a portion of the first fluid line and a macro channel that forms a portion of the second fluid line, wherein the first fluid line includes a plurality of primary input lines in fluid communication with the micro channel, and the second fluid line includes a plurality of secondary input lines in fluid communication with the macro channel, andthe first fluid line includes a micro output line extending from the micro channel to the first pump to provide an output for the micro channel, and the second fluid line includes a macro output line extending from the macro channel to the second pump to provide an output for the macro channel. 19. The compounding system of claim 18, wherein the micro output line has a cross sectional area taken normal to a longitudinal axis of the micro output line that is less than a cross sectional area of the macro output line taken normal to a longitudinal axis of the macro output line. 20. The compounding system of claim 18, wherein the micro channel includes the at least one first input port configured as a micro input port, and the macro channel includes the at least one second input port configured as a macro input port, and the at least one micro input port has a first cross sectional area taken normal to a fluid flowpath of the micro input port, and the at least one macro input port has a second cross sectional area, and the first cross sectional area is less than the second cross sectional area taken normal to a fluid flowpath of the macro input port. 21. The compounding system of claim 20, wherein the micro channel further includes at least one macro input port, and a first material source of the at least two distinct material sources is connected and in fluid communication with both the at least one macro input port of the micro channel and the at least one micro input port of the micro channel. 22. The compounding system of claim 18, wherein the micro channel includes the first output port configured as a micro output port, and the macro channel includes the second output port configured as a macro output port, and the micro output port has a first cross sectional area taken normal to a fluid pathway of the micro output port, and the macro output port has a second cross sectional area taken normal to a fluid pathway of the macro output port, and the first cross sectional area is less than the second cross sectional area. 23. The compounding system of claim 18, wherein the micro output line extending from the micro channel to the first pump has a first cross sectional area taken normal to a fluid pathway of the micro output line, and the macro output line extending from the macro channel to the second pump has a second cross sectional area taken normal to a fluid pathway of the macro output line, and the first cross sectional area is different from the second cross sectional area. 24. The compounding system of claim 17, wherein the pump system is configured such that a first volume of fluid is removed from a first material source of the distinct material sources when the first pump is operated, and a second volume of fluid is removed from a second material source of the distinct material sources when the second pump is operated, and the second volume being different than the first volume. 25. The compounding system of claim 17, wherein the pump system is configured such that a first volume of fluid is removed from a first material source when the first pump is operated, and a second volume of fluid is removed from the first material source when the second pump is operated, and the second volume being different than the first volume. 26. The compounding system of claim 18, wherein an inner diameter of the micro channel located in the manifold is equal to an inner diameter of the macro channel located in the manifold. 27. The compounding system of claim 17, wherein the manifold includes a micro channel that forms a portion of the first fluid line and a macro channel that forms a portion of the second fluid line, wherein the micro channel includes the at least one first input port configured as a micro input port and a macro input port, and a cross-section fluid flow area of the micro input port taken normal to a fluid pathway of the micro input port is different from a cross-section fluid flow area of the macro input port taken normal to a fluid pathway of the macro input port. 28. A compounding device for mixing materials from at least two distinct material sources, comprising: a first fluid line including a portion attached to one of the at least two distinct material sources, and a second fluid line including a portion attached to another of the at least two distinct material sources;a pump system including a first pump and a second pump, the pump system configured to selectively pump fluid from the at least two distinct material sources to a final container via the first fluid line and the second fluid line;a manifold including a portion of the first fluid line in which at least two fluids from the distinct material sources pass and join within the manifold, and including a portion of the second fluid line in which at least two other fluids from the distinct material sources pass and join within the manifold; anda controller configured to control at least one of volume and speed of the fluid being pumped by the pump system, whereinthe controller is configured to cause the first pump to operate concurrently with the second pump and such that at least one of volume and speed of fluid being pumped via the first pump is different from a respective one of at least volume and speed of fluid being pumped via the second pump while the first pump and second pump are concurrently operated. 29. The compounding device of claim 28, wherein the first pump is a rotary pump, and the second pump is a rotary pump, and the first pump is configured to pump a first volume of fluid per unit time when rotating at a first speed, and the second pump is configured to pump a second volume of fluid per unit time when rotating at the first speed, and the first volume of fluid per unit time is different from the second volume of fluid per unit time. 30. The compounding device of claim 28, further comprising: a transfer set including a portion of the first fluid line and a portion of the second fluid line, and the first fluid line is in fluid isolation from the second fluid line. 31. The compounding device of claim 28, wherein the first pump is configured to have a first head value and the second pump is configured to have a second head value, where the first head value is different from the second head value. 32. The compounding device of claim 28, wherein the first pump is a rotary pump including a plurality of rollers and at least one platen, and the controller is configured to correct output of the first pump based on a location of the rollers relative to the at least one platen. 33. The compounding device of claim 28, wherein the at least two distinct material sources includes a first material source, a second material source, and a third material source, and the controller is configured to cause fluid from the first material source and fluid from the second material source to mix upstream with respect to the first pump, and to cause fluid from the third material source to mix with the fluid from the first material source and fluid from the second material source at a location downstream with respect to the first pump.
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이 특허에 인용된 특허 (29)
D\Silva Edmund D. (Highland Park IL), Accurate peristaltic pump.
Di Gianfilippo Aleandro (Arlington Heights IL) Figler Alan A. (Algonquin IL) Huang Leon (Hoffman Estates IL) Warner Donald (Gurnee IL), Device and method for collecting a desired weight amount of a material.
Kircher, Joseph J.; Czarny, Ronald W.; Lewis, Robert E.; Nitzki George, Diane M.; Miller, Joe A., Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures.
Kircher, Joseph J.; Czarny, Ronald W.; Lewis, Robert E.; Nitzki-George, Diane M.; Miller, Joe A., Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures.
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